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The map label for this gene is fbaA [H]

Identifier: 218710594

GI number: 218710594

Start: 2831017

End: 2832093

Strand: Reverse

Name: fbaA [H]

Synonym: VS_2645

Alternate gene names: 218710594

Gene position: 2832093-2831017 (Counterclockwise)

Preceding gene: 294514842

Following gene: 218710593

Centisome position: 85.84

GC content: 45.4

Gene sequence:

>1077_bases
ATGTCTAAGATCTTCGATTTTGTAAAACCTGGTGTAATTTCTGGCGATGACGTACAGAAAGTATTTGAAGTAGCAAAAGA
AAACAAATTTGCTCTTCCTGCAGTAAACGTTGTTGGTACTGACTCTATTAACGCAGTACTAGAAGCGGCTGCTAAAGTTA
AGTCTCCAGTTGTTGTTCAGTTCTCTAACGGCGGCGCTGCATTCTTCGCAGGTAAAGGCGTTAAACTTGAAGGTCAAGGC
GCACAAGTTCTTGGTGCTGTAGCTGGTGCAAAATACGTACACGCTGTCGCTGAGTCTTACGGTGTTCCAGTTATCCTGCA
TACTGACCACGCTGCTAAGAAACTTCTACCATGGATCGACGGTCTACTAGACGCTGGTGAAGAGTTCTTCGCACAAACTG
GTAAGCCTCTATTCTCTTCTCACATGCTAGACCTTTCTGAAGAGTCTCTAGAAGAGAACATCGAAACATGTGCTACTTAC
CTAGCTCGCATGGCTAAAATGGACATGACAATCGAGATCGAACTTGGTTGTACTGGTGGTGAAGAAGACGGCGTTGATAA
CTCTGATATGGACGCATCTGAGCTTTACACTTCTCCAGAAGACGTAGCATACGCATACGAGAAGCTAATGGCAGTTAGCC
CACGTTTCACTATCGCTGCATCTTTCGGTAACGTGCGCGGTGTTTACCAAGCTGGTAACGTTGTACTTACTCCAACTATC
CTACGTGACTCTCAAGCATACTGTGCAGAGAAGTTCGGTATTGCACCTAACGCTCTAAACTTCGTATTCCACGGTGGTTC
TGGTTCTTCTGAAGCAGAAATCCAAGAGTCTATCGGCTACGGTGTTATCAAAATGAACATCGATACTGATACACAGTGGG
CAACTTGGGATGGTATCCGTCAGTACTCTGCTGATAACTTCGATTTCCTACAAGGTCAAATCGGTAACCCAACTGGCGAA
GCTGCGCCAAACAAGAAGTACTACGATCCACGCGTATGGCTACGTGCTGCTCAGTCTTCAATGGTTACTCGTCTTGAGAA
AGCATTCGCTGACCTTAATGCTGTAGACGTACTATAA

Upstream 100 bases:

>100_bases
ACTTATTTGCTAGAATAGCGGAAGTTGTGAGCAAACGATTGCAAACTTTTAAACTTAAGTTTTTTATCTTAAAACGAATA
GAATAAATAGGACTATTTCC

Downstream 100 bases:

>100_bases
TTCTTTGAATTAAGTACTCTTTAAGTTTTAAAAACCCGCTCATTGAGCGGGTTTTTTTATGTCTGATAAAAATTTGTATT
AAATATGTGAAAACCCTAGC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSKIFDFVKPGVISGDDVQKVFEVAKENKFALPAVNVVGTDSINAVLEAAAKVKSPVVVQFSNGGAAFFAGKGVKLEGQG
AQVLGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWIDGLLDAGEEFFAQTGKPLFSSHMLDLSEESLEENIETCATY
LARMAKMDMTIEIELGCTGGEEDGVDNSDMDASELYTSPEDVAYAYEKLMAVSPRFTIAASFGNVRGVYQAGNVVLTPTI
LRDSQAYCAEKFGIAPNALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWATWDGIRQYSADNFDFLQGQIGNPTGE
AAPNKKYYDPRVWLRAAQSSMVTRLEKAFADLNAVDVL

Sequences:

>Translated_358_residues
MSKIFDFVKPGVISGDDVQKVFEVAKENKFALPAVNVVGTDSINAVLEAAAKVKSPVVVQFSNGGAAFFAGKGVKLEGQG
AQVLGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWIDGLLDAGEEFFAQTGKPLFSSHMLDLSEESLEENIETCATY
LARMAKMDMTIEIELGCTGGEEDGVDNSDMDASELYTSPEDVAYAYEKLMAVSPRFTIAASFGNVRGVYQAGNVVLTPTI
LRDSQAYCAEKFGIAPNALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWATWDGIRQYSADNFDFLQGQIGNPTGE
AAPNKKYYDPRVWLRAAQSSMVTRLEKAFADLNAVDVL
>Mature_357_residues
SKIFDFVKPGVISGDDVQKVFEVAKENKFALPAVNVVGTDSINAVLEAAAKVKSPVVVQFSNGGAAFFAGKGVKLEGQGA
QVLGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWIDGLLDAGEEFFAQTGKPLFSSHMLDLSEESLEENIETCATYL
ARMAKMDMTIEIELGCTGGEEDGVDNSDMDASELYTSPEDVAYAYEKLMAVSPRFTIAASFGNVRGVYQAGNVVLTPTIL
RDSQAYCAEKFGIAPNALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWATWDGIRQYSADNFDFLQGQIGNPTGEA
APNKKYYDPRVWLRAAQSSMVTRLEKAFADLNAVDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=75.7660167130919, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI87082041, Length=333, Percent_Identity=25.2252252252252, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789526, Length=317, Percent_Identity=25.5520504731861, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788072, Length=310, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=50.997150997151, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38472; Mature: 38340

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIFDFVKPGVISGDDVQKVFEVAKENKFALPAVNVVGTDSINAVLEAAAKVKSPVVVQ
CCCHHHHHCCCCCCCHHHHHHHHHHHCCCEECCEEEEECCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFFAGKGVKLEGQGAQVLGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWID
ECCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
GLLDAGEEFFAQTGKPLFSSHMLDLSEESLEENIETCATYLARMAKMDMTIEIELGCTGG
HHHHCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
EEDGVDNSDMDASELYTSPEDVAYAYEKLMAVSPRFTIAASFGNVRGVYQAGNVVLTPTI
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCEEEEEHH
LRDSQAYCAEKFGIAPNALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWATWDGIR
HCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCCCCHHHHH
QYSADNFDFLQGQIGNPTGEAAPNKKYYDPRVWLRAAQSSMVTRLEKAFADLNAVDVL
HHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
SKIFDFVKPGVISGDDVQKVFEVAKENKFALPAVNVVGTDSINAVLEAAAKVKSPVVVQ
CCHHHHHCCCCCCCHHHHHHHHHHHCCCEECCEEEEECCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFFAGKGVKLEGQGAQVLGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWID
ECCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
GLLDAGEEFFAQTGKPLFSSHMLDLSEESLEENIETCATYLARMAKMDMTIEIELGCTGG
HHHHCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
EEDGVDNSDMDASELYTSPEDVAYAYEKLMAVSPRFTIAASFGNVRGVYQAGNVVLTPTI
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCEEEEEHH
LRDSQAYCAEKFGIAPNALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWATWDGIR
HCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCCCCHHHHH
QYSADNFDFLQGQIGNPTGEAAPNKKYYDPRVWLRAAQSSMVTRLEKAFADLNAVDVL
HHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]