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The map label for this gene is rnc [H]

Identifier: 218710569

GI number: 218710569

Start: 2808700

End: 2809377

Strand: Reverse

Name: rnc [H]

Synonym: VS_2619

Alternate gene names: 218710569

Gene position: 2809377-2808700 (Counterclockwise)

Preceding gene: 218710570

Following gene: 218710568

Centisome position: 85.15

GC content: 44.25

Gene sequence:

>678_bases
ATGAATTCTCCAATTGATAAACTAGAGAGAAAGATTGGCTATCAGTTTAATGATGCCGATCTTATCCATTTGGCGCTGAC
TCACCGCAGTGCCGCAGGTAAACACAACGAACGTCTTGAGTTTCTGGGCGATTCAATTTTAAGTTTTGTTATCGCTGATG
ATCTTTACCACCGTTTCCCTAAGGTAAACGAAGGTGATATGAGCCGCATGCGCGCAACATTAGTACGTGGTCATACATTG
GCAGAACTAGGTCGTGAATTCGAACTAGGAGATTACTTAAAATTAGGTCCAGGTGAGTTGAAGAGTGGCGGTTTCCGTCG
TGATTCTATTCTAGCGGATGCGGTTGAAGCGATCATCGGCGCTGTCTATTTAGATAGTGATACCGAGGTTGTTCGCCGTA
TTATTTTAAGCTGGTACCAATCTCGCCTAGAGTCTATTCAGCCTGGTGTATCTCAAAAAGATCCAAAAACTCGCTTACAA
GAGTTTTTACAAGGTCGAAGAAATCCCCTACCTGTCTACACAGTGACTAATATTAAAGGTGAAGCACACAACCAAGAGTT
TACGGTTGAGTGTGAAGTGGCAGGTGTGGATAAACCTGTTATCGGTAAAGGCACTAGCCGCCGCAAGGCAGAACAAGCGG
CTGCTGAAACAGCATTAGAGCAACTAAGCAATGTCTGA

Upstream 100 bases:

>100_bases
GCGGTTCAGACAGTGTACTTCCAACATGGATTCCTACTGGTGTGCGTTTTAATCGCATCGGTGGGATTCACTAATCGATC
ACATAACACATCGAGAGAGC

Downstream 100 bases:

>100_bases
TAACAATCAAGATTTCGATATCGATGCATTCTTTTCATCTGATAGCAAAAAAACGGGCCTACCGGAAAACCAACACTGTG
GCTTCATCGCTATCGTGGGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MNSPIDKLERKIGYQFNDADLIHLALTHRSAAGKHNERLEFLGDSILSFVIADDLYHRFPKVNEGDMSRMRATLVRGHTL
AELGREFELGDYLKLGPGELKSGGFRRDSILADAVEAIIGAVYLDSDTEVVRRIILSWYQSRLESIQPGVSQKDPKTRLQ
EFLQGRRNPLPVYTVTNIKGEAHNQEFTVECEVAGVDKPVIGKGTSRRKAEQAAAETALEQLSNV

Sequences:

>Translated_225_residues
MNSPIDKLERKIGYQFNDADLIHLALTHRSAAGKHNERLEFLGDSILSFVIADDLYHRFPKVNEGDMSRMRATLVRGHTL
AELGREFELGDYLKLGPGELKSGGFRRDSILADAVEAIIGAVYLDSDTEVVRRIILSWYQSRLESIQPGVSQKDPKTRLQ
EFLQGRRNPLPVYTVTNIKGEAHNQEFTVECEVAGVDKPVIGKGTSRRKAEQAAAETALEQLSNV
>Mature_225_residues
MNSPIDKLERKIGYQFNDADLIHLALTHRSAAGKHNERLEFLGDSILSFVIADDLYHRFPKVNEGDMSRMRATLVRGHTL
AELGREFELGDYLKLGPGELKSGGFRRDSILADAVEAIIGAVYLDSDTEVVRRIILSWYQSRLESIQPGVSQKDPKTRLQ
EFLQGRRNPLPVYTVTNIKGEAHNQEFTVECEVAGVDKPVIGKGTSRRKAEQAAAETALEQLSNV

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=30.5676855895196, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=30.5676855895196, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788920, Length=218, Percent_Identity=70.6422018348624, Blast_Score=319, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=31.6239316239316, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=31.6239316239316, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=28.82096069869, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25148; Mature: 25148

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPIDKLERKIGYQFNDADLIHLALTHRSAAGKHNERLEFLGDSILSFVIADDLYHRFP
CCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
KVNEGDMSRMRATLVRGHTLAELGREFELGDYLKLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHH
AVYLDSDTEVVRRIILSWYQSRLESIQPGVSQKDPKTRLQEFLQGRRNPLPVYTVTNIKG
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
EAHNQEFTVECEVAGVDKPVIGKGTSRRKAEQAAAETALEQLSNV
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSPIDKLERKIGYQFNDADLIHLALTHRSAAGKHNERLEFLGDSILSFVIADDLYHRFP
CCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
KVNEGDMSRMRATLVRGHTLAELGREFELGDYLKLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHH
AVYLDSDTEVVRRIILSWYQSRLESIQPGVSQKDPKTRLQEFLQGRRNPLPVYTVTNIKG
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
EAHNQEFTVECEVAGVDKPVIGKGTSRRKAEQAAAETALEQLSNV
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA