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The map label for this gene is era [H]

Identifier: 218710568

GI number: 218710568

Start: 2807736

End: 2808707

Strand: Reverse

Name: era [H]

Synonym: VS_2618

Alternate gene names: 218710568

Gene position: 2808707-2807736 (Counterclockwise)

Preceding gene: 218710569

Following gene: 218710567

Centisome position: 85.13

GC content: 44.65

Gene sequence:

>972_bases
ATGTCTGATAACAATCAAGATTTCGATATCGATGCATTCTTTTCATCTGATAGCAAAAAAACGGGCCTACCGGAAAACCA
ACACTGTGGCTTCATCGCTATCGTGGGTCGACCAAACGTAGGTAAATCGACGCTTCTGAACCATATTTTGGGCCAGAAAA
TCTCGATCACATCACGTAAACCTCAGACGACACGCCACCGTATTATGGGCGTAGAAACTGAAGGTGATTACCAAGCGATC
TACGTTGATACTCCTGGACTTCATATCGAAGAAAAGCGTGCAATCAACCGTTTGATGAACCGTGCGGCGAACAGCTCACT
GAGTGATGTGAACCTAGTATTCTTCCTTGTTGACGGTACTCACTGGACTGACGACGATGAAATGGTACTGAACAAGCTGA
GAAAAACAGATTTCCCAGTCGTCCTTTGTATTAACAAAGTAGATAACGTTCAAGACCGTACAGACGTGATGCAACATATG
ATGGAAGTGTCTAAGAAGATGGACTTCCTTGATGTTGTGCCAATCTCAGCGAAGCAAGGTAAGAATATCGATGTACTGCG
TAAGCACGTTCGTAATTCTTTACCAAAAGCGACGCACCACTTCCCTGAAGAGTACGTAACGGATCGCTCACAGCGCTTTA
TGGCCTCTGAAATCATCCGTGAAAAACTGATGCGATTCACAGGCGAAGAGCTACCTTACTCAGTAACGGTTGAGATCGAG
CGTTTTGATTACAACCCAGATAACGATGGTTTCCACATCAATGCTTTGATTCTTGTTGAACGTACTGGTCAGAAGAAGAT
GGTAATTGGTAAAGCGGGCGAGAAGATCAAAACGATTGGTCGTGAAGCTCGTATCGACATGGAAGAACTGTTCGGTCGTA
AGGTTTACTTAGAGACTTGGGTTAAAGTTAAGTCTGGTTGGGCTGACGATGAGCGTGCACTTCGCTCGTTAGGCTACATC
GACGATCTATAA

Upstream 100 bases:

>100_bases
TGTGAAGTGGCAGGTGTGGATAAACCTGTTATCGGTAAAGGCACTAGCCGCCGCAAGGCAGAACAAGCGGCTGCTGAAAC
AGCATTAGAGCAACTAAGCA

Downstream 100 bases:

>100_bases
TATATTGAACGTCACTTTCTGATATTAAGAAAGTTGAATTGAATATAAATACAAGAGAGAGTGCGAACTCTCTCTTTTTG
TATCTGTAAGAAGGGTAAGT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSDNNQDFDIDAFFSSDSKKTGLPENQHCGFIAIVGRPNVGKSTLLNHILGQKISITSRKPQTTRHRIMGVETEGDYQAI
YVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVFFLVDGTHWTDDDEMVLNKLRKTDFPVVLCINKVDNVQDRTDVMQHM
MEVSKKMDFLDVVPISAKQGKNIDVLRKHVRNSLPKATHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIE
RFDYNPDNDGFHINALILVERTGQKKMVIGKAGEKIKTIGREARIDMEELFGRKVYLETWVKVKSGWADDERALRSLGYI
DDL

Sequences:

>Translated_323_residues
MSDNNQDFDIDAFFSSDSKKTGLPENQHCGFIAIVGRPNVGKSTLLNHILGQKISITSRKPQTTRHRIMGVETEGDYQAI
YVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVFFLVDGTHWTDDDEMVLNKLRKTDFPVVLCINKVDNVQDRTDVMQHM
MEVSKKMDFLDVVPISAKQGKNIDVLRKHVRNSLPKATHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIE
RFDYNPDNDGFHINALILVERTGQKKMVIGKAGEKIKTIGREARIDMEELFGRKVYLETWVKVKSGWADDERALRSLGYI
DDL
>Mature_322_residues
SDNNQDFDIDAFFSSDSKKTGLPENQHCGFIAIVGRPNVGKSTLLNHILGQKISITSRKPQTTRHRIMGVETEGDYQAIY
VDTPGLHIEEKRAINRLMNRAANSSLSDVNLVFFLVDGTHWTDDDEMVLNKLRKTDFPVVLCINKVDNVQDRTDVMQHMM
EVSKKMDFLDVVPISAKQGKNIDVLRKHVRNSLPKATHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIER
FDYNPDNDGFHINALILVERTGQKKMVIGKAGEKIKTIGREARIDMEELFGRKVYLETWVKVKSGWADDERALRSLGYID
DL

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=318, Percent_Identity=24.8427672955975, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788919, Length=299, Percent_Identity=72.2408026755853, Blast_Score=452, Evalue=1e-129,
Organism=Escherichia coli, GI87082120, Length=182, Percent_Identity=29.1208791208791, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367268, Length=193, Percent_Identity=28.4974093264249, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646434, Length=317, Percent_Identity=23.9747634069401, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 37062; Mature: 36931

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNNQDFDIDAFFSSDSKKTGLPENQHCGFIAIVGRPNVGKSTLLNHILGQKISITSRK
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEECCCC
PQTTRHRIMGVETEGDYQAIYVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVFFLVDGT
CCCHHHHEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC
HWTDDDEMVLNKLRKTDFPVVLCINKVDNVQDRTDVMQHMMEVSKKMDFLDVVPISAKQG
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KNIDVLRKHVRNSLPKATHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIE
CCHHHHHHHHHHCCCHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
RFDYNPDNDGFHINALILVERTGQKKMVIGKAGEKIKTIGREARIDMEELFGRKVYLETW
EECCCCCCCCEEEEEEEEEEECCCCEEEEECCCHHHHHHHHHHCCCHHHHCCCEEEEHHH
VKVKSGWADDERALRSLGYIDDL
HHHHCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDNNQDFDIDAFFSSDSKKTGLPENQHCGFIAIVGRPNVGKSTLLNHILGQKISITSRK
CCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEECCCC
PQTTRHRIMGVETEGDYQAIYVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVFFLVDGT
CCCHHHHEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC
HWTDDDEMVLNKLRKTDFPVVLCINKVDNVQDRTDVMQHMMEVSKKMDFLDVVPISAKQG
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KNIDVLRKHVRNSLPKATHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIE
CCHHHHHHHHHHCCCHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
RFDYNPDNDGFHINALILVERTGQKKMVIGKAGEKIKTIGREARIDMEELFGRKVYLETW
EECCCCCCCCEEEEEEEEEEECCCCEEEEECCCHHHHHHHHHHCCCHHHHCCCEEEEHHH
VKVKSGWADDERALRSLGYIDDL
HHHHCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]