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The map label for this gene is lepB [H]

Identifier: 218710570

GI number: 218710570

Start: 2809404

End: 2810300

Strand: Reverse

Name: lepB [H]

Synonym: VS_2620

Alternate gene names: 218710570

Gene position: 2810300-2809404 (Counterclockwise)

Preceding gene: 218710571

Following gene: 218710569

Centisome position: 85.18

GC content: 44.82

Gene sequence:

>897_bases
ATGGCTAATACATTTTCGCTTATCTTAGTGATCGTAACTCTAGTGACTGGCATTGTATGGGCGTTGGAAAAGTTTGTGTG
GGCGAAGAAGCGCCAACAAAAACTGGCTGACGTTGAAGCACAGTTGAATGGCCTAGACGCTGCAACCAGCGCAAAAGTTA
CGGCTCAGCCTTGGTGGGTTGAGAACAGTGTGTCCATTTTCCCTGTAATTGCATTTGTTTTGGTTTTGCGTTCATTTATT
TATGAACCGTTTCAAATTCCATCTGGCTCGATGATGCCAACACTATTGGTTGGTGATTTCATCTTGGTAGAAAAGTACGC
TTATGGTCTAAAAGATCCTGTATGGCGCACTCAATTGGTAGAAACAGGCAAACCAGAACGTGGTGATTCAATCGTATTCA
AATACCCACCTCAGCCGAATATCGACTACATCAAGCGTGTTATTGGTATGCCGGGTGATACCATTCGCTACAGCAGCAAT
AAAGAAATCTGCATTCAAGCGAAGGGTGGCAGTAGCTGTAAACCAGTGAAGTTGAGTAACGTTGAAGAAAGCCAATTTAT
TCAAGATGGTGTGCCTCTAATTCAGTTGAATGAACAACTGGGTGACGTGGAGCACCAAATCTTAGTTAACCCATTACGCC
GTGATCGTGTGCAAGCATATCAACCTCGCAATGGTGTTAACGAGTGGATCGTTCCAGAAGGCCAATACTTTGTTATGGGT
GATAACCGTGACAACAGTGCTGACAGCCGTTACTGGGGCTTTGTCCCTGAAGCAAACCTTGTTGGTAAGGCCGTTGCTAT
TTGGATCAGCTTCGAATTCGAACGCGGTTCAGACAGTGTACTTCCAACATGGATTCCTACTGGTGTGCGTTTTAATCGCA
TCGGTGGGATTCACTAA

Upstream 100 bases:

>100_bases
GTCAGCATGATTGATACAAATTAGAAATATTAAGCAGAGTGAAAGAGTTATGCTCTTTCACTTTCGTTATTTTTAAAGAA
ATGAAATTTAAGGGATATCA

Downstream 100 bases:

>100_bases
TCGATCACATAACACATCGAGAGAGCATGAATTCTCCAATTGATAAACTAGAGAGAAAGATTGGCTATCAGTTTAATGAT
GCCGATCTTATCCATTTGGC

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MANTFSLILVIVTLVTGIVWALEKFVWAKKRQQKLADVEAQLNGLDAATSAKVTAQPWWVENSVSIFPVIAFVLVLRSFI
YEPFQIPSGSMMPTLLVGDFILVEKYAYGLKDPVWRTQLVETGKPERGDSIVFKYPPQPNIDYIKRVIGMPGDTIRYSSN
KEICIQAKGGSSCKPVKLSNVEESQFIQDGVPLIQLNEQLGDVEHQILVNPLRRDRVQAYQPRNGVNEWIVPEGQYFVMG
DNRDNSADSRYWGFVPEANLVGKAVAIWISFEFERGSDSVLPTWIPTGVRFNRIGGIH

Sequences:

>Translated_298_residues
MANTFSLILVIVTLVTGIVWALEKFVWAKKRQQKLADVEAQLNGLDAATSAKVTAQPWWVENSVSIFPVIAFVLVLRSFI
YEPFQIPSGSMMPTLLVGDFILVEKYAYGLKDPVWRTQLVETGKPERGDSIVFKYPPQPNIDYIKRVIGMPGDTIRYSSN
KEICIQAKGGSSCKPVKLSNVEESQFIQDGVPLIQLNEQLGDVEHQILVNPLRRDRVQAYQPRNGVNEWIVPEGQYFVMG
DNRDNSADSRYWGFVPEANLVGKAVAIWISFEFERGSDSVLPTWIPTGVRFNRIGGIH
>Mature_297_residues
ANTFSLILVIVTLVTGIVWALEKFVWAKKRQQKLADVEAQLNGLDAATSAKVTAQPWWVENSVSIFPVIAFVLVLRSFIY
EPFQIPSGSMMPTLLVGDFILVEKYAYGLKDPVWRTQLVETGKPERGDSIVFKYPPQPNIDYIKRVIGMPGDTIRYSSNK
EICIQAKGGSSCKPVKLSNVEESQFIQDGVPLIQLNEQLGDVEHQILVNPLRRDRVQAYQPRNGVNEWIVPEGQYFVMGD
NRDNSADSRYWGFVPEANLVGKAVAIWISFEFERGSDSVLPTWIPTGVRFNRIGGIH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=331, Percent_Identity=53.7764350453172, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 33532; Mature: 33401

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTFSLILVIVTLVTGIVWALEKFVWAKKRQQKLADVEAQLNGLDAATSAKVTAQPWWV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEE
ENSVSIFPVIAFVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKYAYGLKDPVWRTQLV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ETGKPERGDSIVFKYPPQPNIDYIKRVIGMPGDTIRYSSNKEICIQAKGGSSCKPVKLSN
HCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCEEECC
VEESQFIQDGVPLIQLNEQLGDVEHQILVNPLRRDRVQAYQPRNGVNEWIVPEGQYFVMG
CCHHHHHHCCCCEEEECHHHCCHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
DNRDNSADSRYWGFVPEANLVGKAVAIWISFEFERGSDSVLPTWIPTGVRFNRIGGIH
CCCCCCCCCCEECCCCCCCHHCCEEEEEEEEEEECCCCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
ANTFSLILVIVTLVTGIVWALEKFVWAKKRQQKLADVEAQLNGLDAATSAKVTAQPWWV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEE
ENSVSIFPVIAFVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKYAYGLKDPVWRTQLV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ETGKPERGDSIVFKYPPQPNIDYIKRVIGMPGDTIRYSSNKEICIQAKGGSSCKPVKLSN
HCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCEEECC
VEESQFIQDGVPLIQLNEQLGDVEHQILVNPLRRDRVQAYQPRNGVNEWIVPEGQYFVMG
CCHHHHHHCCCCEEEECHHHCCHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
DNRDNSADSRYWGFVPEANLVGKAVAIWISFEFERGSDSVLPTWIPTGVRFNRIGGIH
CCCCCCCCCCEECCCCCCCHHCCEEEEEEEEEEECCCCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]