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The map label for this gene is panC

Identifier: 218710494

GI number: 218710494

Start: 2722639

End: 2723529

Strand: Direct

Name: panC

Synonym: VS_2533

Alternate gene names: 218710494

Gene position: 2722639-2723529 (Clockwise)

Preceding gene: 218710493

Following gene: 218710498

Centisome position: 82.52

GC content: 45.12

Gene sequence:

>891_bases
ATGCAAACTTTTGCTGAGATAGCGGCTCTTCGTGAGCAGATTAAACAGTTTAAGCGTGATGGACGTACGGTTGCTTTTGT
CCCAACAATGGGAAACCTACATGAAGGTCACCTAACTCTGGTCAAGAAAGCTCGTGAACTGGCTGACATTGTTGTTGTAA
GCATTTTTGTTAACCCAATGCAGTTTGATCGCGCCGACGACCTAAATAACTACCCTCGTACGTTAGAAGCCGATTTAAAC
AAACTAACAGGCGAAGGTGTTGAGTTAGTCTTTACGCCAACACCAGAGGTGATGTACCCAGATGGATTGGACAAACAGAC
GTTTGTTGAAGTCCCTGGTATATCTCATATGCTTGAAGGTGCCTCTCGTCCAGGTCATTTCCGCGGTGTATCAACAATTG
TCACGAAACTGTTTAATATCGTTCAGCCAGACTTTGCATGCTTCGGTGAGAAAGATTTCCAACAACTTGCTGTGATTCGC
CAGATGACAACTGACTTAGCGCTAGACATTGAAGTTGTGGGCGTAGCGACTGTTCGTGAAATGGATGGTTTAGCAATGAG
CTCTCGCAATAGCAACCTAACGATTGACGAACGTCAGCGAGCTCCAGTTCTAGCGCGCACTATGCGTTGGATCAGCAGTG
CTATTCGTGGTGGTCGTGATGATTACGCGTCTGTCATTGAAGATGCAACAGACCAACTGCGCGCAGCAGACCTACAACCG
GATGAAATATTCATTTGTGATGTGAAAACGTTACAAGCAATCACTTCAGAATCGACTCAAGCAGTGATTCTAATGTCGGC
TTTCCTAGGTAAGACTCGCCTTATCGACAACCAAGTTTTAGATTTGGTCTCGGAAACGAAAGAAGAAGTGAAAGAAGAAA
CTGCTGAGTAA

Upstream 100 bases:

>100_bases
CTGAAACAGGTGATATGCGTAAAGCCGTCGCTCTATACAAAGAAGAAGTAGAGAGCGCACTTTTCCCTGATGATGCTCAT
ACAATCGCTTAGGAGTAACT

Downstream 100 bases:

>100_bases
TCGCTTTCTTCTCTTTACGTAAACCAGGTTCTACCGCAAAGCACAAATGAAAAACATAAAAAAGGTCGATGTAATATCGA
CCTTTTTCTTTGCCTGCGAT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MQTFAEIAALREQIKQFKRDGRTVAFVPTMGNLHEGHLTLVKKARELADIVVVSIFVNPMQFDRADDLNNYPRTLEADLN
KLTGEGVELVFTPTPEVMYPDGLDKQTFVEVPGISHMLEGASRPGHFRGVSTIVTKLFNIVQPDFACFGEKDFQQLAVIR
QMTTDLALDIEVVGVATVREMDGLAMSSRNSNLTIDERQRAPVLARTMRWISSAIRGGRDDYASVIEDATDQLRAADLQP
DEIFICDVKTLQAITSESTQAVILMSAFLGKTRLIDNQVLDLVSETKEEVKEETAE

Sequences:

>Translated_296_residues
MQTFAEIAALREQIKQFKRDGRTVAFVPTMGNLHEGHLTLVKKARELADIVVVSIFVNPMQFDRADDLNNYPRTLEADLN
KLTGEGVELVFTPTPEVMYPDGLDKQTFVEVPGISHMLEGASRPGHFRGVSTIVTKLFNIVQPDFACFGEKDFQQLAVIR
QMTTDLALDIEVVGVATVREMDGLAMSSRNSNLTIDERQRAPVLARTMRWISSAIRGGRDDYASVIEDATDQLRAADLQP
DEIFICDVKTLQAITSESTQAVILMSAFLGKTRLIDNQVLDLVSETKEEVKEETAE
>Mature_296_residues
MQTFAEIAALREQIKQFKRDGRTVAFVPTMGNLHEGHLTLVKKARELADIVVVSIFVNPMQFDRADDLNNYPRTLEADLN
KLTGEGVELVFTPTPEVMYPDGLDKQTFVEVPGISHMLEGASRPGHFRGVSTIVTKLFNIVQPDFACFGEKDFQQLAVIR
QMTTDLALDIEVVGVATVREMDGLAMSSRNSNLTIDERQRAPVLARTMRWISSAIRGGRDDYASVIEDATDQLRAADLQP
DEIFICDVKTLQAITSESTQAVILMSAFLGKTRLIDNQVLDLVSETKEEVKEETAE

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=273, Percent_Identity=54.5787545787546, Blast_Score=313, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6322046, Length=306, Percent_Identity=38.2352941176471, Blast_Score=187, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_VIBSL (B7VK04)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002418115.1
- GeneID:   7162067
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2533
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32964; Mature: 32964

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFAEIAALREQIKQFKRDGRTVAFVPTMGNLHEGHLTLVKKARELADIVVVSIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
QFDRADDLNNYPRTLEADLNKLTGEGVELVFTPTPEVMYPDGLDKQTFVEVPGISHMLEG
HCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEECCCCCCCCCEEECCCHHHHHHC
ASRPGHFRGVSTIVTKLFNIVQPDFACFGEKDFQQLAVIRQMTTDLALDIEVVGVATVRE
CCCCCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHEEEEEEEHHHHHH
MDGLAMSSRNSNLTIDERQRAPVLARTMRWISSAIRGGRDDYASVIEDATDQLRAADLQP
HCCCCCCCCCCCCEECHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
DEIFICDVKTLQAITSESTQAVILMSAFLGKTRLIDNQVLDLVSETKEEVKEETAE
CCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTFAEIAALREQIKQFKRDGRTVAFVPTMGNLHEGHLTLVKKARELADIVVVSIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
QFDRADDLNNYPRTLEADLNKLTGEGVELVFTPTPEVMYPDGLDKQTFVEVPGISHMLEG
HCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEECCCCCCCCCEEECCCHHHHHHC
ASRPGHFRGVSTIVTKLFNIVQPDFACFGEKDFQQLAVIRQMTTDLALDIEVVGVATVRE
CCCCCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHEEEEEEEHHHHHH
MDGLAMSSRNSNLTIDERQRAPVLARTMRWISSAIRGGRDDYASVIEDATDQLRAADLQP
HCCCCCCCCCCCCEECHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
DEIFICDVKTLQAITSESTQAVILMSAFLGKTRLIDNQVLDLVSETKEEVKEETAE
CCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA