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The map label for this gene is can [H]

Identifier: 218710498

GI number: 218710498

Start: 2727612

End: 2728271

Strand: Direct

Name: can [H]

Synonym: VS_2537

Alternate gene names: 218710498

Gene position: 2727612-2728271 (Clockwise)

Preceding gene: 218710494

Following gene: 218710500

Centisome position: 82.67

GC content: 43.64

Gene sequence:

>660_bases
ATGCCAGAGATTAAACAGCTTTTTGAAAACAACTCTAAATGGTCAGAAGAAATTCGCTCTCAACGACCAGAGTATTTTAC
AACGCTTGAAGAGGGTCAAAGCCCTGGTTTTCTATGGATAGGCTGCTCAGATAGCCGCGTTCCAGCCGAGCGTCTCACTG
GTTTGTATTCTGGCGAACTGTTTGTTCACCGAAATGTCGCTAATCAAGTAGTTCATACCGACCTAAACTGCTTATCAGTA
GTGCAATACGCTGTCGATGTACTCAAAGTGAAACACGTTATTGTTTGTGGTCACTACGGCTGTGGCGGTGTTAACGCAGC
GATTGATAACCCTAAACTGGGTCTTATCAACAACTGGCTACTCCACATACGCGATAACTATCTTAAGTACCGTAAGCAAA
TTGAATCTCTGCCTCGTGAACAATGGGGTGACAAGTTATGCGAAATTAACGTTGCAGAACAAGTCTACAATCTTGGTAAC
TCGACCATCATGCAAAGCGCATGGGAACGTGGACAAGATATTGAAATCCACGGTGTGGTTTATGGTATTGGTAATGGCAA
ACTGCAAGATCTTGGTGTTCGTTGCTCAAGTAATGACACCTTAGAAAACAGCCACTTAGCGGCGCTTGATAAAATCCTAT
CGTCTCCAATCCTAGGTTAA

Upstream 100 bases:

>100_bases
GTACACGTCAGATGAGTACTATTTGACACAGTTTTTACAAGATTGAATTTGTAACATTGTGTATAGTTAGAGTTCTTAAT
TAAGGGATGTAAGACGCAAA

Downstream 100 bases:

>100_bases
TTCTTAACGTCTAACCAATAGATATAAGAAAGAATAGATATAAAAAAGGCTCGCGTTTTGCGAGCCTTTTTTGTTTGTGT
TCAACAGAGTCGTTATTACT

Product: carbonic anhydrase 2

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MPEIKQLFENNSKWSEEIRSQRPEYFTTLEEGQSPGFLWIGCSDSRVPAERLTGLYSGELFVHRNVANQVVHTDLNCLSV
VQYAVDVLKVKHVIVCGHYGCGGVNAAIDNPKLGLINNWLLHIRDNYLKYRKQIESLPREQWGDKLCEINVAEQVYNLGN
STIMQSAWERGQDIEIHGVVYGIGNGKLQDLGVRCSSNDTLENSHLAALDKILSSPILG

Sequences:

>Translated_219_residues
MPEIKQLFENNSKWSEEIRSQRPEYFTTLEEGQSPGFLWIGCSDSRVPAERLTGLYSGELFVHRNVANQVVHTDLNCLSV
VQYAVDVLKVKHVIVCGHYGCGGVNAAIDNPKLGLINNWLLHIRDNYLKYRKQIESLPREQWGDKLCEINVAEQVYNLGN
STIMQSAWERGQDIEIHGVVYGIGNGKLQDLGVRCSSNDTLENSHLAALDKILSSPILG
>Mature_218_residues
PEIKQLFENNSKWSEEIRSQRPEYFTTLEEGQSPGFLWIGCSDSRVPAERLTGLYSGELFVHRNVANQVVHTDLNCLSVV
QYAVDVLKVKHVIVCGHYGCGGVNAAIDNPKLGLINNWLLHIRDNYLKYRKQIESLPREQWGDKLCEINVAEQVYNLGNS
TIMQSAWERGQDIEIHGVVYGIGNGKLQDLGVRCSSNDTLENSHLAALDKILSSPILG

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=205, Percent_Identity=63.4146341463415, Blast_Score=279, Evalue=1e-76,
Organism=Escherichia coli, GI1786534, Length=197, Percent_Identity=30.9644670050761, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324292, Length=203, Percent_Identity=29.064039408867, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24581; Mature: 24450

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIKQLFENNSKWSEEIRSQRPEYFTTLEEGQSPGFLWIGCSDSRVPAERLTGLYSGEL
CCHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCEE
FVHRNVANQVVHTDLNCLSVVQYAVDVLKVKHVIVCGHYGCGGVNAAIDNPKLGLINNWL
EEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHH
LHIRDNYLKYRKQIESLPREQWGDKLCEINVAEQVYNLGNSTIMQSAWERGQDIEIHGVV
HHHHHHHHHHHHHHHHCCHHHHCCHHEEEHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEE
YGIGNGKLQDLGVRCSSNDTLENSHLAALDKILSSPILG
EECCCCCEEECCEEECCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PEIKQLFENNSKWSEEIRSQRPEYFTTLEEGQSPGFLWIGCSDSRVPAERLTGLYSGEL
CHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCEE
FVHRNVANQVVHTDLNCLSVVQYAVDVLKVKHVIVCGHYGCGGVNAAIDNPKLGLINNWL
EEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHH
LHIRDNYLKYRKQIESLPREQWGDKLCEINVAEQVYNLGNSTIMQSAWERGQDIEIHGVV
HHHHHHHHHHHHHHHHCCHHHHCCHHEEEHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEE
YGIGNGKLQDLGVRCSSNDTLENSHLAALDKILSSPILG
EECCCCCEEECCEEECCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]