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The map label for this gene is dapA [H]

Identifier: 218710272

GI number: 218710272

Start: 2474273

End: 2475208

Strand: Reverse

Name: dapA [H]

Synonym: VS_2305

Alternate gene names: 218710272

Gene position: 2475208-2474273 (Counterclockwise)

Preceding gene: 218710275

Following gene: 218710271

Centisome position: 75.02

GC content: 44.02

Gene sequence:

>936_bases
GTGTTTATTGATTGGCTTACAGTAACATGCAAAAAGAATAAATTAAGGGAGATAGACATGTTTTCAGGAAGTATCGTTGC
GCTAGTTACACCATTTAATACAGATGGTGAAGTGGATTTCGACAGCCTTAAAAAGTTAGTTGATCACCATGTTGCAGCAG
GTAGTGATGGTCTGGTTGCGGTTGGCACAACTGGTGAGTCTTCAACACTCACTATTGAAGAGCATGTCAAAGTCGTCAAT
AAGGTCGTTGAATTTGCTGATGGCCGTATTCCTGTTATAGCTGGTACGGGTGCAAACGCAACTCACGAATCTGTACTTTT
CAGCCGTTTGCTCAATGGTTCTGGTATTGCTGGTTGCCTGAGCGTAACGCCGTACTACAACAAACCGACTCAAGAAGGTT
TGTACCAACATTACAAAGCAATTGCTGAAGTCAGTGACGTTCCACAGATCCTTTACAATGTACCTGGTCGCACTGCGGTA
GACTTGTTGCCAGAAACGGTTGCTCGCCTTGCAGAGATCGAAAACATCGTTGCACTTAAAGATGCGACTGGTGATCTCGA
AAGAATTGCAATTCACCGTGAACTTTGTGGCGAAGACTTTATCTTACTAAGTGGTGATGACTTAACTGGTCTTGAATTTG
TTAAGCGTGGTGGCGATGGCGTGATCTCTGTAACGAACAATGTTGCAGCTGCTGATATGGCGACTATGTTCAAGCTAGCG
AAGGAAGGCAAGTTTGAGGAAGCAGAAGCGATCAATGAGCGTTTGATGCCTCTACATAAGAATTTGTTCGTTGAGTCTAA
CCCTATTCCCGTAAAATGGGCGGTTCACAAAATGGGTCTGATTGCTGAAGGTGGCTTACGTCTACCACTGACTGAACTAT
CAAAACCAGCTCAACCTGTTGTTGCTCAAGCAATGACTGAAGCGTGCATTTACTAA

Upstream 100 bases:

>100_bases
GTTACCCAAATTCTAGGTCGAACGCGGTTATAAGTCGTTTTACCTCAAACATACGACAATATTTACTGCAGATGTTGCTG
GTAAGCCACTTTAATGTCTT

Downstream 100 bases:

>100_bases
AAACGTATAAAGCAATGCCGAAGCGAACCTTCGGCATTTAGGAGTATAAATGAAGTATTCTCACCAGCTAGTGATCGGTT
CACTGGCTGTTTTCGTTCTT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MFIDWLTVTCKKNKLREIDMFSGSIVALVTPFNTDGEVDFDSLKKLVDHHVAAGSDGLVAVGTTGESSTLTIEEHVKVVN
KVVEFADGRIPVIAGTGANATHESVLFSRLLNGSGIAGCLSVTPYYNKPTQEGLYQHYKAIAEVSDVPQILYNVPGRTAV
DLLPETVARLAEIENIVALKDATGDLERIAIHRELCGEDFILLSGDDLTGLEFVKRGGDGVISVTNNVAAADMATMFKLA
KEGKFEEAEAINERLMPLHKNLFVESNPIPVKWAVHKMGLIAEGGLRLPLTELSKPAQPVVAQAMTEACIY

Sequences:

>Translated_311_residues
MFIDWLTVTCKKNKLREIDMFSGSIVALVTPFNTDGEVDFDSLKKLVDHHVAAGSDGLVAVGTTGESSTLTIEEHVKVVN
KVVEFADGRIPVIAGTGANATHESVLFSRLLNGSGIAGCLSVTPYYNKPTQEGLYQHYKAIAEVSDVPQILYNVPGRTAV
DLLPETVARLAEIENIVALKDATGDLERIAIHRELCGEDFILLSGDDLTGLEFVKRGGDGVISVTNNVAAADMATMFKLA
KEGKFEEAEAINERLMPLHKNLFVESNPIPVKWAVHKMGLIAEGGLRLPLTELSKPAQPVVAQAMTEACIY
>Mature_311_residues
MFIDWLTVTCKKNKLREIDMFSGSIVALVTPFNTDGEVDFDSLKKLVDHHVAAGSDGLVAVGTTGESSTLTIEEHVKVVN
KVVEFADGRIPVIAGTGANATHESVLFSRLLNGSGIAGCLSVTPYYNKPTQEGLYQHYKAIAEVSDVPQILYNVPGRTAV
DLLPETVARLAEIENIVALKDATGDLERIAIHRELCGEDFILLSGDDLTGLEFVKRGGDGVISVTNNVAAADMATMFKLA
KEGKFEEAEAINERLMPLHKNLFVESNPIPVKWAVHKMGLIAEGGLRLPLTELSKPAQPVVAQAMTEACIY

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=28.2229965156794, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=60.5536332179931, Blast_Score=366, Evalue=1e-103,
Organism=Escherichia coli, GI87082415, Length=283, Percent_Identity=31.4487632508834, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786463, Length=241, Percent_Identity=30.7053941908714, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789620, Length=234, Percent_Identity=31.6239316239316, Blast_Score=110, Evalue=9e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33588; Mature: 33588

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIDWLTVTCKKNKLREIDMFSGSIVALVTPFNTDGEVDFDSLKKLVDHHVAAGSDGLVA
CEEEEEEEEECCCCCCEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEE
VGTTGESSTLTIEEHVKVVNKVVEFADGRIPVIAGTGANATHESVLFSRLLNGSGIAGCL
EECCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEE
SVTPYYNKPTQEGLYQHYKAIAEVSDVPQILYNVPGRTAVDLLPETVARLAEIENIVALK
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEE
DATGDLERIAIHRELCGEDFILLSGDDLTGLEFVKRGGDGVISVTNNVAAADMATMFKLA
CCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
KEGKFEEAEAINERLMPLHKNLFVESNPIPVKWAVHKMGLIAEGGLRLPLTELSKPAQPV
HCCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHCCEEECCCCCCCHHHHCCCCHHH
VAQAMTEACIY
HHHHHHHHHCC
>Mature Secondary Structure
MFIDWLTVTCKKNKLREIDMFSGSIVALVTPFNTDGEVDFDSLKKLVDHHVAAGSDGLVA
CEEEEEEEEECCCCCCEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEE
VGTTGESSTLTIEEHVKVVNKVVEFADGRIPVIAGTGANATHESVLFSRLLNGSGIAGCL
EECCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEE
SVTPYYNKPTQEGLYQHYKAIAEVSDVPQILYNVPGRTAVDLLPETVARLAEIENIVALK
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEE
DATGDLERIAIHRELCGEDFILLSGDDLTGLEFVKRGGDGVISVTNNVAAADMATMFKLA
CCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
KEGKFEEAEAINERLMPLHKNLFVESNPIPVKWAVHKMGLIAEGGLRLPLTELSKPAQPV
HCCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHCCEEECCCCCCCHHHHCCCCHHH
VAQAMTEACIY
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA