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The map label for this gene is adk [H]

Identifier: 218710235

GI number: 218710235

Start: 2439342

End: 2439986

Strand: Reverse

Name: adk [H]

Synonym: VS_2268

Alternate gene names: 218710235

Gene position: 2439986-2439342 (Counterclockwise)

Preceding gene: 218710236

Following gene: 218710234

Centisome position: 73.95

GC content: 45.12

Gene sequence:

>645_bases
ATGCGCATCATTCTTCTAGGTGCTCCTGGCGCGGGTAAAGGTACTCAAGCTAACTTCATCATGAACAAATTTGGTATCCC
TCAAATTTCAACTGGTGACATGCTACGTGCTGCTATCAAAGCGGGTACTGAGCTTGGTAAGCAAGCAAAATCAGTAATCG
ACGCTGGTCAGCTAGTTTCTGATGAAATTATCCTTGGTCTAATCAAAGAGCGTATCGCTCAAGATGACTGTGAGAAAGGT
TTCCTACTAGACGGTTTCCCACGCACAATCCCTCAAGCTGATGGCCTAAAAGAAATGGGTATCGCAGTAGACTACGTTGT
TGAATTCGACGTAGCTGACGATGTGATTGTTGAGCGTATGGCTGGTCGTCGTGCTCACCTTCCTTCTGGCCGTACATACC
ACAATGTGTACAACCCGCCTAAAGAAGAAGGTAAAGATGACATCACTGGCGAAGAGCTAGTGGTTCGTGATGATGACAAA
GAAGAAACAGTTCGTGCACGTCTAGGTGTATACCACGATCAAACAGCTCCGCTTATCTCTTACTACGGTAAAGAAGCTGA
AGCAGGTAACACTAAGTACCTTAAGTTCGACGGTACTAAACAAGTTGCTGAAGTTAGTGCAGAACTTGAGAAAGCACTAG
CATAA

Upstream 100 bases:

>100_bases
CTCAGTTGTTACCTAACCTCTCTTGTTCGACTTAAATTGAACCAGAAAGGCGGGATAGTGAGCTTCGGTATAAATCATAA
TTTTTATAAGAGGATTAAAC

Downstream 100 bases:

>100_bases
TTGGCTAACAGCCAGTTTTAGAATTTGATATATTGGAAGCGACCTTAAGGTCGCTTTTTTTGTTTCAATTTTTAGTCATA
TACCAATCTAGATAAACTCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQANFIMNKFGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKG
FLLDGFPRTIPQADGLKEMGIAVDYVVEFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDK
EETVRARLGVYHDQTAPLISYYGKEAEAGNTKYLKFDGTKQVAEVSAELEKALA

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQANFIMNKFGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKG
FLLDGFPRTIPQADGLKEMGIAVDYVVEFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDK
EETVRARLGVYHDQTAPLISYYGKEAEAGNTKYLKFDGTKQVAEVSAELEKALA
>Mature_214_residues
MRIILLGAPGAGKGTQANFIMNKFGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKG
FLLDGFPRTIPQADGLKEMGIAVDYVVEFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDK
EETVRARLGVYHDQTAPLISYYGKEAEAGNTKYLKFDGTKQVAEVSAELEKALA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50, Blast_Score=200, Evalue=7e-52,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=43.2432432432432, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=30.6010928961749, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI22749187, Length=183, Percent_Identity=29.5081967213115, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=29.1208791208791, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=29.1208791208791, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=30.6976744186047, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.1798561151079, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=74.1784037558685, Blast_Score=333, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=44.4954128440367, Blast_Score=199, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17537943, Length=211, Percent_Identity=36.0189573459716, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=32.4175824175824, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=30.1075268817204, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17533833, Length=186, Percent_Identity=31.1827956989247, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=189, Percent_Identity=48.1481481481481, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=43.8144329896907, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=30.6010928961749, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=44.0758293838863, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17737899, Length=213, Percent_Identity=40.8450704225352, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24645822, Length=213, Percent_Identity=40.8450704225352, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=32.0441988950276, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=32.0441988950276, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=30.9859154929577, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=30.9859154929577, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23325; Mature: 23325

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQANFIMNKFGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEMGIAVDYVVEFDVADDVIVERM
HHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHCEEEEEEEEECCHHHHHHHHH
AGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRARLGVYHDQTAPLIS
CCCCCCCCCCCEECCCCCCCHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCHHHH
YYGKEAEAGNTKYLKFDGTKQVAEVSAELEKALA
HCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQANFIMNKFGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEMGIAVDYVVEFDVADDVIVERM
HHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHCEEEEEEEEECCHHHHHHHHH
AGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRARLGVYHDQTAPLIS
CCCCCCCCCCCEECCCCCCCHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCHHHH
YYGKEAEAGNTKYLKFDGTKQVAEVSAELEKALA
HCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA