Click here to switch to the map view.

The map label for this gene is hemH

Identifier: 218710234

GI number: 218710234

Start: 2438103

End: 2439065

Strand: Reverse

Name: hemH

Synonym: VS_2267

Alternate gene names: 218710234

Gene position: 2439065-2438103 (Counterclockwise)

Preceding gene: 218710235

Following gene: 218710232

Centisome position: 73.93

GC content: 46.0

Gene sequence:

>963_bases
ATGGAAAATAATAAAAAGCAGGGCGTTTTACTGGTGAACTTAGGAACACCAGACTCAGCGACCCCAGCTGGCGTTCGTCG
ATTTTTGAGTGAATTCTTACACGACAAGCGAGTCGTAAACTTAACGCGTTGGTTGTGGTGTCCTATTTTACATGGGGTGA
TCTTACCGATTAGAGCGCCGAAAGTGGCTAAGCTGTATCAGTCTGTTTGGATGGATGAAGGCTCACCACTGCTTGTGTAC
TCACAAAGACAAGCCGAAAAGCTCCAGAAAAAATTACAGATACCCGTAGCGCTGGGTATGACCTATGGTAACCCAAGCCT
TAAAACGGGCGTTGAGCAATTAATGGATCAGGGCGTTGAAGACATCATCGTATTGCCTTTATATCCTCAATACTCAGGCA
CAACCACAGCGGCCGTATCTGATGGCTTAACCAAGGCCTTTAAGCAGATGCCAGTGATTCCGAGCTATCGCTTTATTCGC
GACTACTACGCGCACCCAAGCTACGCAAAAGCATTGGCTGAAAGCGTGCGTAGCCATTGGGATAAAAATGGTAGAGCCGA
TCATTTAGTTTGTTCTTTCCACGGTATTCCGAAACGATTGGCTGATGAAGGCGACATCTACCCACAGCATTGTGAAGCGA
CAACAGAGCTCCTTGCTGCTGAGTTAGGCTTATCAGCGGACGATATCACCATGACATACCAATCTCGATTTGGTCGAGAA
GAGTGGTTGAAGCCATACACTGACGAGACACTTGAATCATTGCCAAGCAAAGGCATCAAAAAAATCGATATTATGGCGCC
TGCATTTTCTGTGGATTGTTTAGAAACGTTAGAAGAGATTTCGGATCAGTGTAAAGAGACCTTCATTGACGCTGGTGGCT
CAGACTTTAGCTACATTACGTGTCTGAATGATAGAGACTCGCACATCGATATGATGGCGGAGTTAGTGGCGCTGTATCGT
TAA

Upstream 100 bases:

>100_bases
AGAACGATTATTCTTAAATTTAGTAGCACAACAATGATCTTAAACTTATGTAGATTAGTATATTACGTTCCAGAAAATCA
CATATTGGTCTCAGGTATCT

Downstream 100 bases:

>100_bases
ATACGACTTCGCCTAAACTGTCATGCACATCTAAAAATAACAAAAGGGCTGCTCATTGAGCAGCCCTTTTTGATCTGGAT
GTTTCTTCTTGAAATAGGTC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MENNKKQGVLLVNLGTPDSATPAGVRRFLSEFLHDKRVVNLTRWLWCPILHGVILPIRAPKVAKLYQSVWMDEGSPLLVY
SQRQAEKLQKKLQIPVALGMTYGNPSLKTGVEQLMDQGVEDIIVLPLYPQYSGTTTAAVSDGLTKAFKQMPVIPSYRFIR
DYYAHPSYAKALAESVRSHWDKNGRADHLVCSFHGIPKRLADEGDIYPQHCEATTELLAAELGLSADDITMTYQSRFGRE
EWLKPYTDETLESLPSKGIKKIDIMAPAFSVDCLETLEEISDQCKETFIDAGGSDFSYITCLNDRDSHIDMMAELVALYR

Sequences:

>Translated_320_residues
MENNKKQGVLLVNLGTPDSATPAGVRRFLSEFLHDKRVVNLTRWLWCPILHGVILPIRAPKVAKLYQSVWMDEGSPLLVY
SQRQAEKLQKKLQIPVALGMTYGNPSLKTGVEQLMDQGVEDIIVLPLYPQYSGTTTAAVSDGLTKAFKQMPVIPSYRFIR
DYYAHPSYAKALAESVRSHWDKNGRADHLVCSFHGIPKRLADEGDIYPQHCEATTELLAAELGLSADDITMTYQSRFGRE
EWLKPYTDETLESLPSKGIKKIDIMAPAFSVDCLETLEEISDQCKETFIDAGGSDFSYITCLNDRDSHIDMMAELVALYR
>Mature_320_residues
MENNKKQGVLLVNLGTPDSATPAGVRRFLSEFLHDKRVVNLTRWLWCPILHGVILPIRAPKVAKLYQSVWMDEGSPLLVY
SQRQAEKLQKKLQIPVALGMTYGNPSLKTGVEQLMDQGVEDIIVLPLYPQYSGTTTAAVSDGLTKAFKQMPVIPSYRFIR
DYYAHPSYAKALAESVRSHWDKNGRADHLVCSFHGIPKRLADEGDIYPQHCEATTELLAAELGLSADDITMTYQSRFGRE
EWLKPYTDETLESLPSKGIKKIDIMAPAFSVDCLETLEEISDQCKETFIDAGGSDFSYITCLNDRDSHIDMMAELVALYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=329, Percent_Identity=26.4437689969605, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI60499021, Length=329, Percent_Identity=26.4437689969605, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=54.746835443038, Blast_Score=356, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6324750, Length=337, Percent_Identity=24.3323442136499, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=23.9393939393939, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24651774, Length=264, Percent_Identity=23.4848484848485, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45552018, Length=176, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_VIBSL (B7VII4)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002417855.1
- GeneID:   7161809
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2267
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35967; Mature: 35967

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNKKQGVLLVNLGTPDSATPAGVRRFLSEFLHDKRVVNLTRWLWCPILHGVILPIRAP
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KVAKLYQSVWMDEGSPLLVYSQRQAEKLQKKLQIPVALGMTYGNPSLKTGVEQLMDQGVE
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCC
DIIVLPLYPQYSGTTTAAVSDGLTKAFKQMPVIPSYRFIRDYYAHPSYAKALAESVRSHW
CEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
DKNGRADHLVCSFHGIPKRLADEGDIYPQHCEATTELLAAELGLSADDITMTYQSRFGRE
CCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEHHHHHCCHH
EWLKPYTDETLESLPSKGIKKIDIMAPAFSVDCLETLEEISDQCKETFIDAGGSDFSYIT
HHCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CLNDRDSHIDMMAELVALYR
EECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MENNKKQGVLLVNLGTPDSATPAGVRRFLSEFLHDKRVVNLTRWLWCPILHGVILPIRAP
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KVAKLYQSVWMDEGSPLLVYSQRQAEKLQKKLQIPVALGMTYGNPSLKTGVEQLMDQGVE
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCC
DIIVLPLYPQYSGTTTAAVSDGLTKAFKQMPVIPSYRFIRDYYAHPSYAKALAESVRSHW
CEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
DKNGRADHLVCSFHGIPKRLADEGDIYPQHCEATTELLAAELGLSADDITMTYQSRFGRE
CCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEHHHHHCCHH
EWLKPYTDETLESLPSKGIKKIDIMAPAFSVDCLETLEEISDQCKETFIDAGGSDFSYIT
HHCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CLNDRDSHIDMMAELVALYR
EECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA