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The map label for this gene is menC [H]

Identifier: 218710158

GI number: 218710158

Start: 2337195

End: 2338202

Strand: Reverse

Name: menC [H]

Synonym: VS_2188

Alternate gene names: 218710158

Gene position: 2338202-2337195 (Counterclockwise)

Preceding gene: 218710159

Following gene: 218710157

Centisome position: 70.87

GC content: 45.34

Gene sequence:

>1008_bases
ATGAACTCAGTGAATTCTCAACGTCACGCTAAACTCTACCGTTATCAATTACCTATGGATAGTGGTGTGATTCTTCGTGA
CAATAAGTTGAACGAACGCGTTGGCTATATCATCCAACTTGAGTGTGATGGTAAAACTGGTTTTGGCGAAGTTGCGCCTT
TGCCAGGTTTTAGCCAAGAAGATGCCGAACAAGCTGGCATTCAGCTGCAACACGAATTAGAGCTTTGGAGCCACAATAAC
CCTCAAACGCCTTTTGATGAGTTATATCCTTCTGTTGCCTTCGGTTTTTCGATGGCGATAATGGAATTACGAGGCGAACT
TAACGCTGAAGGTAACTACCAAGCGGCACCGTTGTGTACAGGCGATCCAGATGAATTGATCCCTGTGCTGAATGAGATGA
AAGGTGAGAAGGTCGCCAAAGTGAAAGTCGGTCTCTACGAAGCGATTCGTGATGGCATGCTAGTGAGCTTATTCCTTGAG
TCGATCCCTGATTTGACCCTAAGGCTTGATGCCAACCGCGCGTGGAAACCAGAAAAAGCCAAGCAGTTCATCAAGTACAT
TTCGCCTTCACTGCGTCAACGTATTAGCTTTATTGAAGAGCCTTGCCAGAAACCTGAAGATAGCTTAGCTTTTGCTATTG
ACCACGGTGTTGCGATTGCATGGGACGAAACACTGCAAGAAGCGGTAAGAAGTCCAGAGTTTAATCTTAGTGACTTAACG
GGTGTTAAGGCGGTTGTGATTAAACCAACCTTGATTGGCTCAGTAGAGCGTTGTGTTGCTATCATTGAACGCGCGCAACA
ACTTGGTATTAAACCTGTACTAAGCTCAAGCATAGAGTCTAGCCTTGGTTTAACTCAGATTGCTCGATTGGCACAACAGT
ACTTGCCTAATGAAGTTCCAGGGCTTGATACGATTGGCTTGTATCAGCAACAGCTAGAAGTCTCTTGGCCGGGTTGTCAG
CTTCCAGTTTCAACGCTTGAACAGCAACAATTGATTTGGTCTTCTTAG

Upstream 100 bases:

>100_bases
CGACAAATTTCCGCGTAACCCATAGTCTTTCTCTTCTTTAAAATGAGTCGCTAATAGCGGCTCGTTTTGTTTTGATGTTC
CCCGTTTTTTAGGAAACTTT

Downstream 100 bases:

>100_bases
GCTGATCGTTCGATTGGCTTAGACCGTTCTCAATCTATAACTTGGTTATCTTATGATGCGCCCACAATCTAATCCTCACC
CGCTCTGGGTACAGTGGGCG

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNSVNSQRHAKLYRYQLPMDSGVILRDNKLNERVGYIIQLECDGKTGFGEVAPLPGFSQEDAEQAGIQLQHELELWSHNN
PQTPFDELYPSVAFGFSMAIMELRGELNAEGNYQAAPLCTGDPDELIPVLNEMKGEKVAKVKVGLYEAIRDGMLVSLFLE
SIPDLTLRLDANRAWKPEKAKQFIKYISPSLRQRISFIEEPCQKPEDSLAFAIDHGVAIAWDETLQEAVRSPEFNLSDLT
GVKAVVIKPTLIGSVERCVAIIERAQQLGIKPVLSSSIESSLGLTQIARLAQQYLPNEVPGLDTIGLYQQQLEVSWPGCQ
LPVSTLEQQQLIWSS

Sequences:

>Translated_335_residues
MNSVNSQRHAKLYRYQLPMDSGVILRDNKLNERVGYIIQLECDGKTGFGEVAPLPGFSQEDAEQAGIQLQHELELWSHNN
PQTPFDELYPSVAFGFSMAIMELRGELNAEGNYQAAPLCTGDPDELIPVLNEMKGEKVAKVKVGLYEAIRDGMLVSLFLE
SIPDLTLRLDANRAWKPEKAKQFIKYISPSLRQRISFIEEPCQKPEDSLAFAIDHGVAIAWDETLQEAVRSPEFNLSDLT
GVKAVVIKPTLIGSVERCVAIIERAQQLGIKPVLSSSIESSLGLTQIARLAQQYLPNEVPGLDTIGLYQQQLEVSWPGCQ
LPVSTLEQQQLIWSS
>Mature_335_residues
MNSVNSQRHAKLYRYQLPMDSGVILRDNKLNERVGYIIQLECDGKTGFGEVAPLPGFSQEDAEQAGIQLQHELELWSHNN
PQTPFDELYPSVAFGFSMAIMELRGELNAEGNYQAAPLCTGDPDELIPVLNEMKGEKVAKVKVGLYEAIRDGMLVSLFLE
SIPDLTLRLDANRAWKPEKAKQFIKYISPSLRQRISFIEEPCQKPEDSLAFAIDHGVAIAWDETLQEAVRSPEFNLSDLT
GVKAVVIKPTLIGSVERCVAIIERAQQLGIKPVLSSSIESSLGLTQIARLAQQYLPNEVPGLDTIGLYQQQLEVSWPGCQ
LPVSTLEQQQLIWSS

Specific function: Converts SHCHC to OSB [H]

COG id: COG1441

COG function: function code H; O-succinylbenzoate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788596, Length=316, Percent_Identity=54.4303797468354, Blast_Score=335, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013342
- InterPro:   IPR010196 [H]

Pfam domain/function: PF01188 MR_MLE [H]

EC number: =4.2.1.113 [H]

Molecular weight: Translated: 37293; Mature: 37293

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVNSQRHAKLYRYQLPMDSGVILRDNKLNERVGYIIQLECDGKTGFGEVAPLPGFSQE
CCCCCCHHHHHHHEEECCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHH
DAEQAGIQLQHELELWSHNNPQTPFDELYPSVAFGFSMAIMELRGELNAEGNYQAAPLCT
HHHHHCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
GDPDELIPVLNEMKGEKVAKVKVGLYEAIRDGMLVSLFLESIPDLTLRLDANRAWKPEKA
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCCHHH
KQFIKYISPSLRQRISFIEEPCQKPEDSLAFAIDHGVAIAWDETLQEAVRSPEFNLSDLT
HHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCCCHHHC
GVKAVVIKPTLIGSVERCVAIIERAQQLGIKPVLSSSIESSLGLTQIARLAQQYLPNEVP
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
GLDTIGLYQQQLEVSWPGCQLPVSTLEQQQLIWSS
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNSVNSQRHAKLYRYQLPMDSGVILRDNKLNERVGYIIQLECDGKTGFGEVAPLPGFSQE
CCCCCCHHHHHHHEEECCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHH
DAEQAGIQLQHELELWSHNNPQTPFDELYPSVAFGFSMAIMELRGELNAEGNYQAAPLCT
HHHHHCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
GDPDELIPVLNEMKGEKVAKVKVGLYEAIRDGMLVSLFLESIPDLTLRLDANRAWKPEKA
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCCHHH
KQFIKYISPSLRQRISFIEEPCQKPEDSLAFAIDHGVAIAWDETLQEAVRSPEFNLSDLT
HHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCCCHHHC
GVKAVVIKPTLIGSVERCVAIIERAQQLGIKPVLSSSIESSLGLTQIARLAQQYLPNEVP
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
GLDTIGLYQQQLEVSWPGCQLPVSTLEQQQLIWSS
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]