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The map label for this gene is menB [H]

Identifier: 218710159

GI number: 218710159

Start: 2338278

End: 2339174

Strand: Reverse

Name: menB [H]

Synonym: VS_2189

Alternate gene names: 218710159

Gene position: 2339174-2338278 (Counterclockwise)

Preceding gene: 218710160

Following gene: 218710158

Centisome position: 70.9

GC content: 48.27

Gene sequence:

>897_bases
GTGGTCTCTAATAGAACAATGGGAATCACCATGGCTAAAACAGTAGGCATCACAGAAGAAGAACTTTACGCAGCAGTTAA
CTGGCGCGATGAAAGCAGTCAATTTGAAGATATTCAGTACCACAAGTCTGACGACGGTATTGCGAAAATCACGATTGCTC
GTCCTCAAGTCCACAATGCGTTCCGTCCACAAACCGTAAAAGAGATGATCAATGCATTGGCTGATGCTCGTTATGACGAG
AAGGTTGGCGTAATCATTTTGACGGGGCTTGGTGAGAAGGCGTTCTGTTCTGGCGGTGACCAAAGTATCCGTGGTGACTA
CGGCGGTTATCAAGATGATTCAGGTACACATCACCTGAATGTACTTGATTTCCAACGTCAAATTCGTACTTGTCCAAAAC
CGGTTATCGCAGCGGTATCGGGTTGGGCAGTCGGTGGCGGTCATGTACTTCACATGATGGCAGACCTGACCATTGCAGCT
GAAAACGCACAGTTTGGTCAGACGGGTCCTAAAGTAGGTTCATTCGATGGCGGTTGGGGTGCTTCTTACATGGCTCGTAT
CGTTGGCCAAAAGAAAGCGCGTGAAATCTGGTTCTTGTGTCGTTTCTACGATGCTCAAGAAGCATTGGACATGGGTCTAG
TAAACACAGTTGTACCGGTTGCTGACCTAGAAAAAGAAACGGTTCGTTGGTGTCGTGAGGTTCTTCAACACAGCCCAATG
GCGCTGCGTTGCTTGAAAGCCGCACTAAACGCAGACTGTGACGGCCAAGCCGGTCTACAAGAGTTGGCGGGTAACGCAAC
CATGATGTTCTACATGACAGAAGAAGGTCAAGAAGGCCGAAACGCATTTAACGAGAAGCGTCGACCTGATTTCGACAAAT
TTCCGCGTAACCCATAG

Upstream 100 bases:

>100_bases
CATCCAATGTATCGCCAGTCGTTGCTAAACAGGCTGAGCGGTTCTCTCGTATCAAGCACTATCAAAAGCAGAGCAACACC
GTCACGACTATTCGTTAGTC

Downstream 100 bases:

>100_bases
TCTTTCTCTTCTTTAAAATGAGTCGCTAATAGCGGCTCGTTTTGTTTTGATGTTCCCCGTTTTTTAGGAAACTTTATGAA
CTCAGTGAATTCTCAACGTC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MVSNRTMGITMAKTVGITEEELYAAVNWRDESSQFEDIQYHKSDDGIAKITIARPQVHNAFRPQTVKEMINALADARYDE
KVGVIILTGLGEKAFCSGGDQSIRGDYGGYQDDSGTHHLNVLDFQRQIRTCPKPVIAAVSGWAVGGGHVLHMMADLTIAA
ENAQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCREVLQHSPM
ALRCLKAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP

Sequences:

>Translated_298_residues
MVSNRTMGITMAKTVGITEEELYAAVNWRDESSQFEDIQYHKSDDGIAKITIARPQVHNAFRPQTVKEMINALADARYDE
KVGVIILTGLGEKAFCSGGDQSIRGDYGGYQDDSGTHHLNVLDFQRQIRTCPKPVIAAVSGWAVGGGHVLHMMADLTIAA
ENAQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCREVLQHSPM
ALRCLKAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
>Mature_298_residues
MVSNRTMGITMAKTVGITEEELYAAVNWRDESSQFEDIQYHKSDDGIAKITIARPQVHNAFRPQTVKEMINALADARYDE
KVGVIILTGLGEKAFCSGGDQSIRGDYGGYQDDSGTHHLNVLDFQRQIRTCPKPVIAAVSGWAVGGGHVLHMMADLTIAA
ENAQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCREVLQHSPM
ALRCLKAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=271, Percent_Identity=33.210332103321, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=30.1587301587302, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=28.8461538461538, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI25453481, Length=251, Percent_Identity=24.3027888446215, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI51538573, Length=251, Percent_Identity=24.3027888446215, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4757966, Length=251, Percent_Identity=24.3027888446215, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI51538581, Length=251, Percent_Identity=24.3027888446215, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4757968, Length=251, Percent_Identity=24.3027888446215, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI49355787, Length=251, Percent_Identity=24.3027888446215, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI116235487, Length=234, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI213417737, Length=224, Percent_Identity=23.6607142857143, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=23.6607142857143, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=84.2857142857143, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=31.4285714285714, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=29.535864978903, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=30.1960784313725, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787660, Length=258, Percent_Identity=28.2945736434109, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=32.5301204819277, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=32.8063241106719, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=208, Percent_Identity=30.2884615384615, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=27.6190476190476, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=211, Percent_Identity=28.9099526066351, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=26.3959390862944, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=232, Percent_Identity=28.0172413793103, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=270, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653477, Length=270, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=28.6274509803922, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357171, Length=184, Percent_Identity=29.8913043478261, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654903, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32975; Mature: 32975

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00018 EF_HAND_1 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSNRTMGITMAKTVGITEEELYAAVNWRDESSQFEDIQYHKSDDGIAKITIARPQVHNA
CCCCCEEEEEEHHHCCCCHHHHEEEECCCCCCCCCCHHEEECCCCCEEEEEEECCHHHCC
FRPQTVKEMINALADARYDEKVGVIILTGLGEKAFCSGGDQSIRGDYGGYQDDSGTHHLN
CCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEE
VLDFQRQIRTCPKPVIAAVSGWAVGGGHVLHMMADLTIAAENAQFGQTGPKVGSFDGGWG
HHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCH
ASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCREVLQHSPM
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCH
ALRCLKAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
HHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCC
>Mature Secondary Structure
MVSNRTMGITMAKTVGITEEELYAAVNWRDESSQFEDIQYHKSDDGIAKITIARPQVHNA
CCCCCEEEEEEHHHCCCCHHHHEEEECCCCCCCCCCHHEEECCCCCEEEEEEECCHHHCC
FRPQTVKEMINALADARYDEKVGVIILTGLGEKAFCSGGDQSIRGDYGGYQDDSGTHHLN
CCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEE
VLDFQRQIRTCPKPVIAAVSGWAVGGGHVLHMMADLTIAAENAQFGQTGPKVGSFDGGWG
HHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCH
ASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCREVLQHSPM
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCH
ALRCLKAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
HHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]