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The map label for this gene is metC [H]

Identifier: 218709963

GI number: 218709963

Start: 2128537

End: 2129721

Strand: Direct

Name: metC [H]

Synonym: VS_1982

Alternate gene names: 218709963

Gene position: 2128537-2129721 (Clockwise)

Preceding gene: 218709962

Following gene: 218709973

Centisome position: 64.51

GC content: 46.41

Gene sequence:

>1185_bases
ATGTCCGAGAACAAAACCACTAAACTGATCACTGCAGGTCGTGATAAGAAGTGGACTAATGGTGTCGTTAACCCACCAGT
ACAACGCGCTTCAACTGTCGTGTTCAACACAGTAGAAGAGAAACGCAAAGCGACCATTAACCGCGCTAACAAGACACTTT
TCTACGGACGCCGTGGCACCACGACTCATTTCGCATTTCAAGATGCAATGGTTGAAGTTGAAGGTGGTGCAGGTTGCGCA
CTCTACCCTTGTGGTACGGCAGCCATCTCTAATGCCATCCTCTCTTTTGTTGAAACAGGTGACCATATTCTGATGGTCGA
TACCTGTTACGAACCCACTCGTGATTTCTGTGACACCATAATGAAAAAGATGGGTGTAGAGACCACTTACTACGAGCCAA
CGATCGGTCAAGGTATCCAAGACCTTATTAAGCCAAATACTAAGGTTCTATTTACTGAATCTCCGGGTTCAGTCACCATG
GAAGTTCAAGACATCCCAACACTCGCACGTATTGCTCATCAACATGACATCATTGTAATGCTTGATAACACGTGGGCGGC
TGGTGTTAACTTCTCACCGTTCGATTTTGGCGTCGACATCTCAATTCAAGCGGCGACTAAATACATTGTTGGTCACTCTG
ATGTGATGCTAGGAACGGCGGTAGCCAACGAAAAATGTTGGGATCAACTGAGAGAGCAGAGTTACTTGATGGGACAGTGC
GTATCTCCAGATGACGCTTATCTTGGTCTTCGCGGTATTCGCACTCTTGACGTTCGACTTCGCCAACATGCTGAAAGCAG
CCTAAAAGTAGCAAAGTGGTTAGAAACACGCCCTGAGGTTGACCATGTTCGTCACCCTGCCCTTGAGTCTTGTCCCGGTC
ATGAATTCTTCAAACGAGACTTCACTGGCGGTAATGGTTTGTTCTCTTTCGTTCTTAAGAACTCAAACACAAAAGCAACG
ACTGCTCTGCTTGATGGTATGACGCACTTTAGTATGGGTTACTCATGGGGTGGATTTGAAAGTTTGATTCTAGCGAACGA
ACCGAGCAGCTTTAATAGCTTGAGAACGGTAGCGAACCCTAACTTCGAAGGAACCTTGATACGCGTTCATATCGGCTTAG
AAGACGTCGATGACCTGATTGCGGATCTAGAAGCTGGACTAGATCGTTACAACGCTCTGGTTTAA

Upstream 100 bases:

>100_bases
AAAGCAAAAGAAAAGCGCAAAAACTCCCGCTCTCCTCTTGCTTTGAAGGCTATTGGCATGTTTTAAATAGGACATAACCG
ATTGATAAGGAATTCACAGC

Downstream 100 bases:

>100_bases
GTAAAACAATAAACAAGTTTCCACAAAAAGGCAGGGATAACCTGCCTTTTTTAGTTCGGTAAGCTCTTGGTGTAGAAGTT
ATATGACTACTTCTGGACCT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSENKTTKLITAGRDKKWTNGVVNPPVQRASTVVFNTVEEKRKATINRANKTLFYGRRGTTTHFAFQDAMVEVEGGAGCA
LYPCGTAAISNAILSFVETGDHILMVDTCYEPTRDFCDTIMKKMGVETTYYEPTIGQGIQDLIKPNTKVLFTESPGSVTM
EVQDIPTLARIAHQHDIIVMLDNTWAAGVNFSPFDFGVDISIQAATKYIVGHSDVMLGTAVANEKCWDQLREQSYLMGQC
VSPDDAYLGLRGIRTLDVRLRQHAESSLKVAKWLETRPEVDHVRHPALESCPGHEFFKRDFTGGNGLFSFVLKNSNTKAT
TALLDGMTHFSMGYSWGGFESLILANEPSSFNSLRTVANPNFEGTLIRVHIGLEDVDDLIADLEAGLDRYNALV

Sequences:

>Translated_394_residues
MSENKTTKLITAGRDKKWTNGVVNPPVQRASTVVFNTVEEKRKATINRANKTLFYGRRGTTTHFAFQDAMVEVEGGAGCA
LYPCGTAAISNAILSFVETGDHILMVDTCYEPTRDFCDTIMKKMGVETTYYEPTIGQGIQDLIKPNTKVLFTESPGSVTM
EVQDIPTLARIAHQHDIIVMLDNTWAAGVNFSPFDFGVDISIQAATKYIVGHSDVMLGTAVANEKCWDQLREQSYLMGQC
VSPDDAYLGLRGIRTLDVRLRQHAESSLKVAKWLETRPEVDHVRHPALESCPGHEFFKRDFTGGNGLFSFVLKNSNTKAT
TALLDGMTHFSMGYSWGGFESLILANEPSSFNSLRTVANPNFEGTLIRVHIGLEDVDDLIADLEAGLDRYNALV
>Mature_393_residues
SENKTTKLITAGRDKKWTNGVVNPPVQRASTVVFNTVEEKRKATINRANKTLFYGRRGTTTHFAFQDAMVEVEGGAGCAL
YPCGTAAISNAILSFVETGDHILMVDTCYEPTRDFCDTIMKKMGVETTYYEPTIGQGIQDLIKPNTKVLFTESPGSVTME
VQDIPTLARIAHQHDIIVMLDNTWAAGVNFSPFDFGVDISIQAATKYIVGHSDVMLGTAVANEKCWDQLREQSYLMGQCV
SPDDAYLGLRGIRTLDVRLRQHAESSLKVAKWLETRPEVDHVRHPALESCPGHEFFKRDFTGGNGLFSFVLKNSNTKATT
ALLDGMTHFSMGYSWGGFESLILANEPSSFNSLRTVANPNFEGTLIRVHIGLEDVDDLIADLEAGLDRYNALV

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=373, Percent_Identity=31.9034852546917, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI299473759, Length=373, Percent_Identity=29.4906166219839, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI25453487, Length=372, Percent_Identity=27.6881720430108, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1789383, Length=393, Percent_Identity=59.7964376590331, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1790375, Length=396, Percent_Identity=29.5454545454545, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=373, Percent_Identity=32.171581769437, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=31.0526315789474, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=370, Percent_Identity=31.6216216216216, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=46.1309523809524, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319307, Length=352, Percent_Identity=30.6818181818182, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=387, Percent_Identity=25.5813953488372, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323333, Length=352, Percent_Identity=28.125, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321254, Length=256, Percent_Identity=27.34375, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=32.5641025641026, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43534; Mature: 43403

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENKTTKLITAGRDKKWTNGVVNPPVQRASTVVFNTVEEKRKATINRANKTLFYGRRGT
CCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHEEHHHHHHHHHHHHHCCCEEEECCCCC
TTHFAFQDAMVEVEGGAGCALYPCGTAAISNAILSFVETGDHILMVDTCYEPTRDFCDTI
EEEEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
MKKMGVETTYYEPTIGQGIQDLIKPNTKVLFTESPGSVTMEVQDIPTLARIAHQHDIIVM
HHHHCCCCEEECCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCEEEE
LDNTWAAGVNFSPFDFGVDISIQAATKYIVGHSDVMLGTAVANEKCWDQLREQSYLMGQC
ECCCEECCCCCCCCCCCEEEEEEEHEEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHCCC
VSPDDAYLGLRGIRTLDVRLRQHAESSLKVAKWLETRPEVDHVRHPALESCPGHEFFKRD
CCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHCCCCHHHHHHC
FTGGNGLFSFVLKNSNTKATTALLDGMTHFSMGYSWGGFESLILANEPSSFNSLRTVANP
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHCCC
NFEGTLIRVHIGLEDVDDLIADLEAGLDRYNALV
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SENKTTKLITAGRDKKWTNGVVNPPVQRASTVVFNTVEEKRKATINRANKTLFYGRRGT
CCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHEEHHHHHHHHHHHHHCCCEEEECCCCC
TTHFAFQDAMVEVEGGAGCALYPCGTAAISNAILSFVETGDHILMVDTCYEPTRDFCDTI
EEEEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
MKKMGVETTYYEPTIGQGIQDLIKPNTKVLFTESPGSVTMEVQDIPTLARIAHQHDIIVM
HHHHCCCCEEECCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCEEEE
LDNTWAAGVNFSPFDFGVDISIQAATKYIVGHSDVMLGTAVANEKCWDQLREQSYLMGQC
ECCCEECCCCCCCCCCCEEEEEEEHEEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHCCC
VSPDDAYLGLRGIRTLDVRLRQHAESSLKVAKWLETRPEVDHVRHPALESCPGHEFFKRD
CCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHCCCCHHHHHHC
FTGGNGLFSFVLKNSNTKATTALLDGMTHFSMGYSWGGFESLILANEPSSFNSLRTVANP
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHCCC
NFEGTLIRVHIGLEDVDDLIADLEAGLDRYNALV
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]