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The map label for this gene is ddc [H]

Identifier: 218709821

GI number: 218709821

Start: 1973316

End: 1974959

Strand: Direct

Name: ddc [H]

Synonym: VS_1833

Alternate gene names: 218709821

Gene position: 1973316-1974959 (Clockwise)

Preceding gene: 218709820

Following gene: 218709822

Centisome position: 59.81

GC content: 44.65

Gene sequence:

>1644_bases
ATGGTTACGGAACAAAAAACAGCAGATGTTAGCTTTGACAGTCTTCTACGTATCTTTACAGTACCAGAAGGCCCAGACTC
AACACTCACTCAAATCGAAGACAAACTTTCACGAAACCTGAATCAATTCTTACGTGAACACATTGTGGCTGAAGAAAAGC
CATTACGTGAGATTGAGAAAGATTTTTCGAATGCTCATATCCCAGAGCAGCCTGAGTTTGTTTCAGAACATACCGAGCAT
CTCCTCGATTCTCTTGTATCTCATTCTGTACATACGTCGTCGCCAAGTTTTATTGGTCACATGACGTCTGCGCTACCCTA
TTTCCTGATGCCGCTGTCTAAAATCATGATTGCGCTAAATCAGAATCTAGTAAAAATCGAGACCTCAAAAGCTTTCACTC
CCCTAGAACGTCAAGTTCTGGGTATGTTACATCGCCTGATATATCAGGATAGCGACCAGTTTTATTCTCGCTGGATGCAC
AGTGCCAACCACTCTTTAGGAGCGTTTTGTTCTGGCGGTACCATCGCGAACATAACAGCGCTTTGGGTTGCACGTAACAA
CGCGCTAAAAGCACAAGGTTCGTTCAAAGGTGTGGAAAAAGAAGGCTTGTTTAAAGCCATGAAGCACTACGGCTACGAAG
GCCTTGCTATCTTGGTTTCTGAACGTGGTCACTACTCTCTGAAAAAAGCAGCGGATGTCCTTGGTATTGGTCAAGAAGGT
CTAGTGTCTGTTAAAACAGATAACGACAACCGCATTTGTACGGACGACCTAAGACTCAAGATTGAACAGCTCAAGCAGAA
TAAGATAAAGCCTTTCGCTGTCATTGGTGTGGCTGGTACAACCGAAACCGGTAATATCGACCCTCTAAGAGACATTGCAG
AAGTGTGTGCTGAATCCGATTGTCATTTCCATGTTGATGCCGCTTGGGGCGGTGCGACTCTAATGTCGAACAACCATCGT
CACCTACTTGATGGTATTGAATTGGCTGATTCAGTTACGATTGATGCACATAAACAGCTTTATATCCCTATGGGTGCTGG
CATGGTTTTGTTTAAGAAGCCAGATGCGATGACCGCAATCGAACATCACGCTCAATACATCCTTCGCAAAGGCTCAAAAG
ACTTAGGTAGCCATACGTTAGAAGGCTCTCGTTCAGGTATGGCAATGTTAGTCTACGCCTCAATGCACATCATCAGTCGC
CCTGGGTATGAACTGCTGATCGACCAGAGCATCAATAAAGCGCGCTACTTTGCTGACCTGATTAAAAATCAAAACGACTT
CGAACTGGTTTCAGAGCCTGAGCTTTGCCTACTGACCTATCGCTATGTGCCTGAATCAGTCAAAGCAGCACTACTCAAGG
CTAAAGCACCAGAGCGTGTTGAACTGAATGAGCTACTGAATGAACTGACCAAGTTTATTCAGAAGAAGCAACGTGAAACG
GGCAAGTCTTTCGTATCGAGAACCCGCTTAAACCCCGAAATATGGGCGCATCAGCCAATCATCGTTTTCCGTGTAGTATT
AGCAAACCCACTGACGGGCAAAGACATTCTCTCTTCTGTGCTTGAAGAACAGCGTGAAATCTCTAAACTAGCACCCAACT
TGATGAGTAAAATCACCAAATTGGTTAAGCTAATCAACGCCTAA

Upstream 100 bases:

>100_bases
TTTATGGGAAGTTGGATTTCATAATTAAGACGGGACATTGTTCCCGTTTTCGTTTAGATTATCCCGCTCGCGTCAATATA
AGAAAAATAACTCGCTTGCT

Downstream 100 bases:

>100_bases
CCATTCAATTTTAGTTGCATCAAATTGAAAATTTCTTTCTTTTTGATGTAACTTAGCTGTCAGTTCATACTCAATTTGCA
TTCTTTTTGCTCAAACCCTC

Product: glutamate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MVTEQKTADVSFDSLLRIFTVPEGPDSTLTQIEDKLSRNLNQFLREHIVAEEKPLREIEKDFSNAHIPEQPEFVSEHTEH
LLDSLVSHSVHTSSPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIYQDSDQFYSRWMH
SANHSLGAFCSGGTIANITALWVARNNALKAQGSFKGVEKEGLFKAMKHYGYEGLAILVSERGHYSLKKAADVLGIGQEG
LVSVKTDNDNRICTDDLRLKIEQLKQNKIKPFAVIGVAGTTETGNIDPLRDIAEVCAESDCHFHVDAAWGGATLMSNNHR
HLLDGIELADSVTIDAHKQLYIPMGAGMVLFKKPDAMTAIEHHAQYILRKGSKDLGSHTLEGSRSGMAMLVYASMHIISR
PGYELLIDQSINKARYFADLIKNQNDFELVSEPELCLLTYRYVPESVKAALLKAKAPERVELNELLNELTKFIQKKQRET
GKSFVSRTRLNPEIWAHQPIIVFRVVLANPLTGKDILSSVLEEQREISKLAPNLMSKITKLVKLINA

Sequences:

>Translated_547_residues
MVTEQKTADVSFDSLLRIFTVPEGPDSTLTQIEDKLSRNLNQFLREHIVAEEKPLREIEKDFSNAHIPEQPEFVSEHTEH
LLDSLVSHSVHTSSPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIYQDSDQFYSRWMH
SANHSLGAFCSGGTIANITALWVARNNALKAQGSFKGVEKEGLFKAMKHYGYEGLAILVSERGHYSLKKAADVLGIGQEG
LVSVKTDNDNRICTDDLRLKIEQLKQNKIKPFAVIGVAGTTETGNIDPLRDIAEVCAESDCHFHVDAAWGGATLMSNNHR
HLLDGIELADSVTIDAHKQLYIPMGAGMVLFKKPDAMTAIEHHAQYILRKGSKDLGSHTLEGSRSGMAMLVYASMHIISR
PGYELLIDQSINKARYFADLIKNQNDFELVSEPELCLLTYRYVPESVKAALLKAKAPERVELNELLNELTKFIQKKQRET
GKSFVSRTRLNPEIWAHQPIIVFRVVLANPLTGKDILSSVLEEQREISKLAPNLMSKITKLVKLINA
>Mature_547_residues
MVTEQKTADVSFDSLLRIFTVPEGPDSTLTQIEDKLSRNLNQFLREHIVAEEKPLREIEKDFSNAHIPEQPEFVSEHTEH
LLDSLVSHSVHTSSPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIYQDSDQFYSRWMH
SANHSLGAFCSGGTIANITALWVARNNALKAQGSFKGVEKEGLFKAMKHYGYEGLAILVSERGHYSLKKAADVLGIGQEG
LVSVKTDNDNRICTDDLRLKIEQLKQNKIKPFAVIGVAGTTETGNIDPLRDIAEVCAESDCHFHVDAAWGGATLMSNNHR
HLLDGIELADSVTIDAHKQLYIPMGAGMVLFKKPDAMTAIEHHAQYILRKGSKDLGSHTLEGSRSGMAMLVYASMHIISR
PGYELLIDQSINKARYFADLIKNQNDFELVSEPELCLLTYRYVPESVKAALLKAKAPERVELNELLNELTKFIQKKQRET
GKSFVSRTRLNPEIWAHQPIIVFRVVLANPLTGKDILSSVLEEQREISKLAPNLMSKITKLVKLINA

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=482, Percent_Identity=26.9709543568465, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4503875, Length=482, Percent_Identity=26.9709543568465, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI58331246, Length=483, Percent_Identity=26.9151138716356, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI197383062, Length=455, Percent_Identity=27.6923076923077, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI194294551, Length=445, Percent_Identity=28.9887640449438, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4503281, Length=384, Percent_Identity=21.3541666666667, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI132814448, Length=384, Percent_Identity=21.3541666666667, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI92110055, Length=357, Percent_Identity=22.96918767507, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17555682, Length=473, Percent_Identity=26.6384778012685, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71993062, Length=451, Percent_Identity=26.3858093126386, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71993058, Length=388, Percent_Identity=28.0927835051546, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17534817, Length=280, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17534819, Length=280, Percent_Identity=25.7142857142857, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136594, Length=465, Percent_Identity=27.741935483871, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24657193, Length=395, Percent_Identity=27.8481012658228, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24657185, Length=395, Percent_Identity=27.8481012658228, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24657188, Length=395, Percent_Identity=27.8481012658228, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356415, Length=432, Percent_Identity=25.2314814814815, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24652373, Length=412, Percent_Identity=24.7572815533981, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221476190, Length=227, Percent_Identity=25.1101321585903, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585143, Length=227, Percent_Identity=25.1101321585903, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585139, Length=227, Percent_Identity=25.1101321585903, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 61244; Mature: 61244

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTEQKTADVSFDSLLRIFTVPEGPDSTLTQIEDKLSRNLNQFLREHIVAEEKPLREIEK
CCCCCCCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DFSNAHIPEQPEFVSEHTEHLLDSLVSHSVHTSSPSFIGHMTSALPYFLMPLSKIMIALN
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMLHRLIYQDSDQFYSRWMHSANHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEE
LWVARNNALKAQGSFKGVEKEGLFKAMKHYGYEGLAILVSERGHYSLKKAADVLGIGQEG
EEEEECCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
LVSVKTDNDNRICTDDLRLKIEQLKQNKIKPFAVIGVAGTTETGNIDPLRDIAEVCAESD
EEEEEECCCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCC
CHFHVDAAWGGATLMSNNHRHLLDGIELADSVTIDAHKQLYIPMGAGMVLFKKPDAMTAI
CCEEEECCCCCEEEECCCCHHHHHHHHHHCCEEEECCCEEEEEECCCEEEEECCCHHHHH
EHHAQYILRKGSKDLGSHTLEGSRSGMAMLVYASMHIISRPGYELLIDQSINKARYFADL
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEEHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
IKNQNDFELVSEPELCLLTYRYVPESVKAALLKAKAPERVELNELLNELTKFIQKKQRET
HCCCCCCEECCCCCEEEEEEHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GKSFVSRTRLNPEIWAHQPIIVFRVVLANPLTGKDILSSVLEEQREISKLAPNLMSKITK
HHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVKLINA
HHHHHCC
>Mature Secondary Structure
MVTEQKTADVSFDSLLRIFTVPEGPDSTLTQIEDKLSRNLNQFLREHIVAEEKPLREIEK
CCCCCCCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DFSNAHIPEQPEFVSEHTEHLLDSLVSHSVHTSSPSFIGHMTSALPYFLMPLSKIMIALN
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMLHRLIYQDSDQFYSRWMHSANHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEE
LWVARNNALKAQGSFKGVEKEGLFKAMKHYGYEGLAILVSERGHYSLKKAADVLGIGQEG
EEEEECCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
LVSVKTDNDNRICTDDLRLKIEQLKQNKIKPFAVIGVAGTTETGNIDPLRDIAEVCAESD
EEEEEECCCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCC
CHFHVDAAWGGATLMSNNHRHLLDGIELADSVTIDAHKQLYIPMGAGMVLFKKPDAMTAI
CCEEEECCCCCEEEECCCCHHHHHHHHHHCCEEEECCCEEEEEECCCEEEEECCCHHHHH
EHHAQYILRKGSKDLGSHTLEGSRSGMAMLVYASMHIISRPGYELLIDQSINKARYFADL
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEEHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
IKNQNDFELVSEPELCLLTYRYVPESVKAALLKAKAPERVELNELLNELTKFIQKKQRET
HCCCCCCEECCCCCEEEEEEHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GKSFVSRTRLNPEIWAHQPIIVFRVVLANPLTGKDILSSVLEEQREISKLAPNLMSKITK
HHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVKLINA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]