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The map label for this gene is hexR [H]

Identifier: 218709822

GI number: 218709822

Start: 1975319

End: 1976173

Strand: Direct

Name: hexR [H]

Synonym: VS_1834

Alternate gene names: 218709822

Gene position: 1975319-1976173 (Clockwise)

Preceding gene: 218709821

Following gene: 218709824

Centisome position: 59.87

GC content: 44.21

Gene sequence:

>855_bases
ATGAATACATTAGAAAAAATACAAAAAAACCTGGAAAACTTCAGCAAGTCTGAGCGTAAGGTAGCCGAAGTAATCATGGC
TTCCCCTCAAACTGCAATTCATTCTAGCATTGCTACCTTAGCTAAAATGGCTGACGTGAGTGAGCCTACAGTTAACCGCT
TCTGTCGTCGTTTAGACACAAAGGGCTTCCCTGACTTTAAACTTCACCTAGCTCAAAGCTTGGCGAACGGTACACCTTAC
GTGAACCGTAATGTTGAAGAAGATGACGGCCCAGATGCTTACACGCATAAGATTTTTGAATCAACTATGGCTTGTCTAGA
TGTTGCTAAAAACAGTTTAGACGCGATGCAAGTAAACCGAGCGGTTGACCTGCTGACTCAAGCAAAACGCATTTCGTTCT
TCGGACTGGGTGCCTCTTCTGCTGTAGCCAAAGATGCTCAAAACAAATTCATTCGTTTCAATATCCCAATCACTTGTTTC
GAAGACATCGTGATGCAACGCATGAGCTGCATTAACTGCAGTGATAACGATGTTATTGTTCTGATCTCTCACACTGGCCG
CACTAAAAGCCAAGTAGAGATTGCGAACTTAGCTCGTGAAAACGGGGCGACAGTTATCGCTATCACAGCAAAAGACTCTC
CGCTAGATAAAGCGAGTTCTCTGTCTATCTCATTGGATGTACCGGAAGACACTGACGTTTACATGCCAATGGCAAGTCGT
GTTGTTCAGATGACGGTTATCGATGTGTTAGCAACAGGCTTTACGCTTCGTCGTGGTTCTGGCTTCCGAGAGAACCTGAA
ACGAGTAAAAGAGTCGCTTCGTGATTCACGTTACGAAAAGTACTCTCAGTTCTAA

Upstream 100 bases:

>100_bases
AATATAAGTTTGGTTTTGTATTTTCTTATATTTGTTTCAGCCATACCCCCTGGTAAAAGATATTAACTAGCAAGTTGTTC
TCTATACCCTTGTGAACACT

Downstream 100 bases:

>100_bases
TCTGTTAAGATGTGAGCTTAAGAATTAAATTCAATTGAAAAACGGAGCCTAGCGCTCCGTTTTTATTTGTCTGTTTAAAT
GGGTTATGTCGTGATGGGTT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDAMQVNRAVDLLTQAKRISFFGLGASSAVAKDAQNKFIRFNIPITCF
EDIVMQRMSCINCSDNDVIVLISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSISLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGSGFRENLKRVKESLRDSRYEKYSQF

Sequences:

>Translated_284_residues
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDAMQVNRAVDLLTQAKRISFFGLGASSAVAKDAQNKFIRFNIPITCF
EDIVMQRMSCINCSDNDVIVLISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSISLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGSGFRENLKRVKESLRDSRYEKYSQF
>Mature_284_residues
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDAMQVNRAVDLLTQAKRISFFGLGASSAVAKDAQNKFIRFNIPITCF
EDIVMQRMSCINCSDNDVIVLISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSISLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGSGFRENLKRVKESLRDSRYEKYSQF

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=71.4285714285714, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=23.75, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788767, Length=269, Percent_Identity=26.3940520446097, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082130, Length=214, Percent_Identity=28.5046728971963, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31558; Mature: 31558

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDAMQVNR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKRISFFGLGASSAVAKDAQNKFIRFNIPITCFEDIVMQRMSCINCSDNDVIV
HHHHHHHHHHHHEEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSISLDVPEDTDVYMPMASR
EEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCEEHHHHHH
VVQMTVIDVLATGFTLRRGSGFRENLKRVKESLRDSRYEKYSQF
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDAMQVNR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKRISFFGLGASSAVAKDAQNKFIRFNIPITCFEDIVMQRMSCINCSDNDVIV
HHHHHHHHHHHHEEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSISLDVPEDTDVYMPMASR
EEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCEEHHHHHH
VVQMTVIDVLATGFTLRRGSGFRENLKRVKESLRDSRYEKYSQF
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]