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The map label for this gene is folX [H]

Identifier: 218709737

GI number: 218709737

Start: 1871558

End: 1871935

Strand: Direct

Name: folX [H]

Synonym: VS_1749

Alternate gene names: 218709737

Gene position: 1871558-1871935 (Clockwise)

Preceding gene: 218709736

Following gene: 218709738

Centisome position: 56.73

GC content: 43.92

Gene sequence:

>378_bases
ATGAATCACAACGCCATTATCACCATTACAAACCTGAGACTAAGAACCTTCATCGGCTTCAACGAAGAAGAAAAGTCTAA
GCAGCAAGACATCGTTATCAATGCAGAAATCCACTACCCCGCGAACAACCTTTGTCTCTCAGATGATGTGGAGAACGCGC
TTAACTACAAAAACATCTGCAAGAAGATCATTCAACACGTCGAATCCGGAAGGTTCCTGCTTTTGGAAAAATTGACCAGC
GACGTACTCGGCATCTGTATCGATCATCCATGGGTGAAATACGCTCAAGTGAGAATCGACAAGCCTCATGCGCTACGTTT
TGCTGACTCTGTTTCGCTCACTCTGAGCTATGAAGCAGACAACGACAATATTTCATAA

Upstream 100 bases:

>100_bases
GGCTAAAGGAACGACTGAACTCTTAATCACCTGAGCTTTACTGATCTTTTCTTAAAACAAGCACGTAACTGACTTCACTT
TCTAAGGATTGGACACTGTT

Downstream 100 bases:

>100_bases
GGAGTGCGTCATGCTGAACACAGAAGCCGAAAAAGTAAGAGAAGCTTTGCTCGCAAGAGGACTTGAAACTCCAATGACAC
CGAGCGAAATGAATCCCAAC

Product: D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase

Products: L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

Alternate protein names: Dihydroneopterin triphosphate 2'-epimerase [H]

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MNHNAIITITNLRLRTFIGFNEEEKSKQQDIVINAEIHYPANNLCLSDDVENALNYKNICKKIIQHVESGRFLLLEKLTS
DVLGICIDHPWVKYAQVRIDKPHALRFADSVSLTLSYEADNDNIS

Sequences:

>Translated_125_residues
MNHNAIITITNLRLRTFIGFNEEEKSKQQDIVINAEIHYPANNLCLSDDVENALNYKNICKKIIQHVESGRFLLLEKLTS
DVLGICIDHPWVKYAQVRIDKPHALRFADSVSLTLSYEADNDNIS
>Mature_125_residues
MNHNAIITITNLRLRTFIGFNEEEKSKQQDIVINAEIHYPANNLCLSDDVENALNYKNICKKIIQHVESGRFLLLEKLTS
DVLGICIDHPWVKYAQVRIDKPHALRFADSVSLTLSYEADNDNIS

Specific function: Catalyzes the epimerization of carbon 2' of the side chain of dihydroneopterin triphosphate (H2NTP) to form dihydromonapterin triphosphate (H2MTP) [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI1788641, Length=114, Percent_Identity=64.0350877192982, Blast_Score=150, Evalue=3e-38,
Organism=Escherichia coli, GI87082204, Length=113, Percent_Identity=29.2035398230088, Blast_Score=63, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: 5.-.-.- [C]

Molecular weight: Translated: 14311; Mature: 14311

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHNAIITITNLRLRTFIGFNEEEKSKQQDIVINAEIHYPANNLCLSDDVENALNYKNIC
CCCCEEEEEECEEEEEEECCCCHHCCCCCCEEEEEEEECCCCCCEECCCHHHHCCHHHHH
KKIIQHVESGRFLLLEKLTSDVLGICIDHPWVKYAQVRIDKPHALRFADSVSLTLSYEAD
HHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCEEEEEEEECC
NDNIS
CCCCC
>Mature Secondary Structure
MNHNAIITITNLRLRTFIGFNEEEKSKQQDIVINAEIHYPANNLCLSDDVENALNYKNIC
CCCCEEEEEECEEEEEEECCCCHHCCCCCCEEEEEEEECCCCCCEECCCHHHHCCHHHHH
KKIIQHVESGRFLLLEKLTSDVLGICIDHPWVKYAQVRIDKPHALRFADSVSLTLSYEAD
HHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCEEEEEEEECC
NDNIS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Erythro-7,8-Dihydroneopterin Triphosphate [C]

Specific reaction: D-Erythro-7,8-Dihydroneopterin Triphosphate = L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]