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The map label for this gene is fnr [H]

Identifier: 218709458

GI number: 218709458

Start: 1599709

End: 1600455

Strand: Direct

Name: fnr [H]

Synonym: VS_1467

Alternate gene names: 218709458

Gene position: 1599709-1600455 (Clockwise)

Preceding gene: 218709457

Following gene: 218709459

Centisome position: 48.49

GC content: 42.84

Gene sequence:

>747_bases
ATGATTTCTGAAAAGCCTGTGACGAAACGTGTTCAGTCTGGTGGCTGTGCGATCCATTGCCAGGATTGTAGTATTAGCCA
GCTCTGTATTCCGTTTACTTTGAATGAATCTGAACTCGATCAACTTGATCAGATCATTGAGAGAAAAAAGCCTATTCAAA
AAGGCCAAGAGTTATTTAAAGCCGGTGACGAGCTTAAATCTCTATACGCTATTCGCTCTGGAACGATCAAGAGCTACACG
ATTACCGAGCAAGGTGATGAGCAAATTACTGCATTCCATCTAGCGGGCGATCTTGTTGGCTTCGATGCGATTACTGGTGA
CATGCACCCTAGTTTCGCACAAGCGTTAGAAACTTCTATGGTATGTGAAATTCCATACGAAATTCTAGACGACCTATCAG
GAAAAATGCCTAAATTGCGTCAGCAAATTATGCGTCTGATGAGTAACGAGATTAAAGGTGACCAAGAAATGATTCTGCTT
CTTTCTAAGAAGAACGCGGAAGAGCGTCTTGCTGCATTCCTTTACAACCTTTCTACTCGTTTCTCTCAACGTGGCTTCAG
CCCACGTGAGTTTCGCCTAACGATGACTCGTGGCGATATTGGTAACTACCTTGGTTTGACTGTTGAAACAATTAGCCGTC
TTTTAGGTCGCTTCCAAAAAGCAGACATCTTGAGCGTTAAAGGCAAATATATCACTATCGAAGATCACGATGCGTTGATG
GAACTTGCTGGCGTTTCAAAAGAATAG

Upstream 100 bases:

>100_bases
TTTATACCGTATAGCGGCGTCTTTAATCCGGTTTTTTTACTACCCTTTAGGATTAAGGAATGCTAAAATATTGACGTATA
TCAAATAGTGAAAGATTGTT

Downstream 100 bases:

>100_bases
TCTAGATATCAATGATGTAGTTCAATAATGAGCTACATCATGTTTCTCTCTTAAAACCTCTTATATTTCTCTTATTCTCT
CCATAACTACGCTACATTAT

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MISEKPVTKRVQSGGCAIHCQDCSISQLCIPFTLNESELDQLDQIIERKKPIQKGQELFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAITGDMHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILL
LSKKNAEERLAAFLYNLSTRFSQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKADILSVKGKYITIEDHDALM
ELAGVSKE

Sequences:

>Translated_248_residues
MISEKPVTKRVQSGGCAIHCQDCSISQLCIPFTLNESELDQLDQIIERKKPIQKGQELFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAITGDMHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILL
LSKKNAEERLAAFLYNLSTRFSQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKADILSVKGKYITIEDHDALM
ELAGVSKE
>Mature_248_residues
MISEKPVTKRVQSGGCAIHCQDCSISQLCIPFTLNESELDQLDQIIERKKPIQKGQELFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAITGDMHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILL
LSKKNAEERLAAFLYNLSTRFSQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKADILSVKGKYITIEDHDALM
ELAGVSKE

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=248, Percent_Identity=85.8870967741936, Blast_Score=443, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27848; Mature: 27848

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEKPVTKRVQSGGCAIHCQDCSISQLCIPFTLNESELDQLDQIIERKKPIQKGQELFK
CCCCCCHHHHHHCCCCEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITAFHLAGDLVGFDAITGDMHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
VCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILLLSKKNAEERLAAFLYNLSTR
HHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FSQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKADILSVKGKYITIEDHDALM
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHH
ELAGVSKE
HHHCCCCC
>Mature Secondary Structure
MISEKPVTKRVQSGGCAIHCQDCSISQLCIPFTLNESELDQLDQIIERKKPIQKGQELFK
CCCCCCHHHHHHCCCCEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITAFHLAGDLVGFDAITGDMHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
VCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILLLSKKNAEERLAAFLYNLSTR
HHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FSQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKADILSVKGKYITIEDHDALM
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHH
ELAGVSKE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA