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The map label for this gene is luxQ [H]

Identifier: 218709447

GI number: 218709447

Start: 1588912

End: 1590636

Strand: Reverse

Name: luxQ [H]

Synonym: VS_1456

Alternate gene names: 218709447

Gene position: 1590636-1588912 (Counterclockwise)

Preceding gene: 218709448

Following gene: 218709446

Centisome position: 48.21

GC content: 40.99

Gene sequence:

>1725_bases
ATGGATACTGAAGACCAAGAAGCGCTGCAAGAAGCTCGTATTGAACTCCAAAAACTAAAGGTCCGTGAACGTAAATTAGC
TGAAGAGAATAGGGTGATCCTATCGACTATCTCTGCGATCAGTAAGGCGAGTAACATATCTGAAATATTTTCTAGTCTCG
AATTTGCACTCAAAAAATACATTAAGTTTGATGATTTTATTGTGGTATCAAGAGTAGGGAATGAGGGTAGTTTCAAAACC
CTGTTAACCAATAACAAAGTATTCGAACAAATGAATTGGACAGATTGTGGCAAGCTATCGCGAGTCATTAATGGAGAATG
TGCGATTCTTTTTGAACCCAAATCTCTGGGTGAATTCAGCACTTTGCATCCCATTATCCTAGACCAAATTAACTCTGTAC
TGATTACTGGTATTGATAGCGGGCTAACACAATCCGTTATCATCTTTATCCATTCCAATACCAAACACTTTAGTATTGAA
ACCAAAGCCACTCTAAACCGATTTCGACCGCTGATTGAGCGTGCTGTTTTCGATATTGAAAACAAAGAAAAACTTGAAGC
GACAGTCCGAGAACGTACAGCAGAACTCGTAGCAGCAAGAAAAGACGCAGAAAGAGCCAACAAAGCCAAATCTGAATTCT
TAGCAATGATGAGTCATGAGTTAAGAACGCCGCTAAACGCTACCATAGGCTTAATCGACACGCTAAAGTCCACACCGCTG
AATGATGAACAACAGTCTATATTGTTAAATATGAGTACATCATCTGAACTCCTATTGGCGATCATCAGTGATGTTTTGGA
CTTTTCAAAGATTGAATCTGGATGCTTCTCGTTGGCTCCTCAATGGAGTAACGCAAGAGACACTGTAACTTTTGTTTTAT
CTGAACAAAAGAAGATAGCAGACGATAAAGGGTTGTCATTAACCCTAACTAGCGACATTCCAGAAGGTGAACTACATTAC
ATCGACCCAAGTCGCTTAGCACAGATCCTTTTTAATCTCATTGGTAACGCAATAAAGTTCACTGAACACGGGCATGTACA
TGTTTCTATTACATACCAGCACAGTTCATTCCGTATTAGCGTAGAAGACACCGGAATTGGCATCAGCTCACAGCAACTTT
CGTCATTATTCAGTCCGTTCGTGCAAGCCGATAGCACAATCACACGTAGGTTTGGTGGCACCGGCTTAGGTTTAGCAATA
ACAAAACGACTAGTAGAACTGATGCGCGGGCATATATCGGTCGAGAGTGAGCCAGGAAAAGGCTCGAAATTTGAAGTGCG
GTTACCAGTTCTAACGAGAGTTACGAACAATCAAGATCATGCTGCAGAAGATAAATACTCGCAAGTTCCCAGAACCCGTT
ATTCAGTGTTAGTTGTTGAAGACAACCCAACCAATCAGATGGTGATTCAATTGATCCTTGCGCGGCAAGGCCATGAAGTT
TTCATCGCAAGCAACGGTGAAGAAGCCATTGGCTTTGTAGAAAGAGGTAATGACCCGATAGACATTATCTTGATGGATGT
GTCGATGCCAGTTATGGACGGAATAACCACAACCAAATACATGAGAGACGCAAACATCAAAACACCAATCGTCGCGCTAA
CGGCACACACATCAGTAGAAGATAAATTTTCTTGTTTAGATGTCGGTATGAATGATTTCATTACCAAACCTGTAAGAACC
AAAGAGATCATTGAAGCAATTGATCGATTAATGCTTGAAGTCTAA

Upstream 100 bases:

>100_bases
GTCCATTTACGTTTGGTGAGCAAGGCAGACTCTCTGGTGGTGAGAATGCGCACGGAAATTTGATGGTATCGTCTGCAACG
TTTTATAGGCTGAAAAAGTA

Downstream 100 bases:

>100_bases
TAAACGTATTCTTAATCGAAGATTAGGAAATATGTTTATTAGGTATTTTATGGTAAATAGACTTACTGTTAAATAGATCG
TCAGTTTGGTAGTCAAATAA

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MDTEDQEALQEARIELQKLKVRERKLAEENRVILSTISAISKASNISEIFSSLEFALKKYIKFDDFIVVSRVGNEGSFKT
LLTNNKVFEQMNWTDCGKLSRVINGECAILFEPKSLGEFSTLHPIILDQINSVLITGIDSGLTQSVIIFIHSNTKHFSIE
TKATLNRFRPLIERAVFDIENKEKLEATVRERTAELVAARKDAERANKAKSEFLAMMSHELRTPLNATIGLIDTLKSTPL
NDEQQSILLNMSTSSELLLAIISDVLDFSKIESGCFSLAPQWSNARDTVTFVLSEQKKIADDKGLSLTLTSDIPEGELHY
IDPSRLAQILFNLIGNAIKFTEHGHVHVSITYQHSSFRISVEDTGIGISSQQLSSLFSPFVQADSTITRRFGGTGLGLAI
TKRLVELMRGHISVESEPGKGSKFEVRLPVLTRVTNNQDHAAEDKYSQVPRTRYSVLVVEDNPTNQMVIQLILARQGHEV
FIASNGEEAIGFVERGNDPIDIILMDVSMPVMDGITTTKYMRDANIKTPIVALTAHTSVEDKFSCLDVGMNDFITKPVRT
KEIIEAIDRLMLEV

Sequences:

>Translated_574_residues
MDTEDQEALQEARIELQKLKVRERKLAEENRVILSTISAISKASNISEIFSSLEFALKKYIKFDDFIVVSRVGNEGSFKT
LLTNNKVFEQMNWTDCGKLSRVINGECAILFEPKSLGEFSTLHPIILDQINSVLITGIDSGLTQSVIIFIHSNTKHFSIE
TKATLNRFRPLIERAVFDIENKEKLEATVRERTAELVAARKDAERANKAKSEFLAMMSHELRTPLNATIGLIDTLKSTPL
NDEQQSILLNMSTSSELLLAIISDVLDFSKIESGCFSLAPQWSNARDTVTFVLSEQKKIADDKGLSLTLTSDIPEGELHY
IDPSRLAQILFNLIGNAIKFTEHGHVHVSITYQHSSFRISVEDTGIGISSQQLSSLFSPFVQADSTITRRFGGTGLGLAI
TKRLVELMRGHISVESEPGKGSKFEVRLPVLTRVTNNQDHAAEDKYSQVPRTRYSVLVVEDNPTNQMVIQLILARQGHEV
FIASNGEEAIGFVERGNDPIDIILMDVSMPVMDGITTTKYMRDANIKTPIVALTAHTSVEDKFSCLDVGMNDFITKPVRT
KEIIEAIDRLMLEV
>Mature_574_residues
MDTEDQEALQEARIELQKLKVRERKLAEENRVILSTISAISKASNISEIFSSLEFALKKYIKFDDFIVVSRVGNEGSFKT
LLTNNKVFEQMNWTDCGKLSRVINGECAILFEPKSLGEFSTLHPIILDQINSVLITGIDSGLTQSVIIFIHSNTKHFSIE
TKATLNRFRPLIERAVFDIENKEKLEATVRERTAELVAARKDAERANKAKSEFLAMMSHELRTPLNATIGLIDTLKSTPL
NDEQQSILLNMSTSSELLLAIISDVLDFSKIESGCFSLAPQWSNARDTVTFVLSEQKKIADDKGLSLTLTSDIPEGELHY
IDPSRLAQILFNLIGNAIKFTEHGHVHVSITYQHSSFRISVEDTGIGISSQQLSSLFSPFVQADSTITRRFGGTGLGLAI
TKRLVELMRGHISVESEPGKGSKFEVRLPVLTRVTNNQDHAAEDKYSQVPRTRYSVLVVEDNPTNQMVIQLILARQGHEV
FIASNGEEAIGFVERGNDPIDIILMDVSMPVMDGITTTKYMRDANIKTPIVALTAHTSVEDKFSCLDVGMNDFITKPVRT
KEIIEAIDRLMLEV

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=378, Percent_Identity=33.5978835978836, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI48994928, Length=366, Percent_Identity=35.2459016393443, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=44.4444444444444, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081816, Length=400, Percent_Identity=32, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=39.922480620155, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=31.858407079646, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=29.7777777777778, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=28.1512605042017, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786912, Length=296, Percent_Identity=25, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=29.5275590551181, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=25.7510729613734, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787894, Length=319, Percent_Identity=25.3918495297806, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=27.3504273504274, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787375, Length=117, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=33.9805825242718, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082012, Length=112, Percent_Identity=30.3571428571429, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=72, Percent_Identity=51.3888888888889, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322000, Length=117, Percent_Identity=34.1880341880342, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64049; Mature: 64049

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTEDQEALQEARIELQKLKVRERKLAEENRVILSTISAISKASNISEIFSSLEFALKKY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IKFDDFIVVSRVGNEGSFKTLLTNNKVFEQMNWTDCGKLSRVINGECAILFEPKSLGEFS
CCCCCEEEEEECCCCCCEEEEEECCHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCCCH
TLHPIILDQINSVLITGIDSGLTQSVIIFIHSNTKHFSIETKATLNRFRPLIERAVFDIE
HHHHHHHHHHCCEEEECCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHCCC
NKEKLEATVRERTAELVAARKDAERANKAKSEFLAMMSHELRTPLNATIGLIDTLKSTPL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
NDEQQSILLNMSTSSELLLAIISDVLDFSKIESGCFSLAPQWSNARDTVTFVLSEQKKIA
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHCC
DDKGLSLTLTSDIPEGELHYIDPSRLAQILFNLIGNAIKFTEHGHVHVSITYQHSSFRIS
CCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECEEEEE
VEDTGIGISSQQLSSLFSPFVQADSTITRRFGGTGLGLAITKRLVELMRGHISVESEPGK
EECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCEEEECCCCC
GSKFEVRLPVLTRVTNNQDHAAEDKYSQVPRTRYSVLVVEDNPTNQMVIQLILARQGHEV
CCEEEEEEEEEEEECCCCCCCCCHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEE
FIASNGEEAIGFVERGNDPIDIILMDVSMPVMDGITTTKYMRDANIKTPIVALTAHTSVE
EEECCCCHHEEHHHCCCCCEEEEEEECCCHHHCCCHHHHHHCCCCCCCCEEEEEECCCCC
DKFSCLDVGMNDFITKPVRTKEIIEAIDRLMLEV
CCHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTEDQEALQEARIELQKLKVRERKLAEENRVILSTISAISKASNISEIFSSLEFALKKY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IKFDDFIVVSRVGNEGSFKTLLTNNKVFEQMNWTDCGKLSRVINGECAILFEPKSLGEFS
CCCCCEEEEEECCCCCCEEEEEECCHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCCCH
TLHPIILDQINSVLITGIDSGLTQSVIIFIHSNTKHFSIETKATLNRFRPLIERAVFDIE
HHHHHHHHHHCCEEEECCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHCCC
NKEKLEATVRERTAELVAARKDAERANKAKSEFLAMMSHELRTPLNATIGLIDTLKSTPL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
NDEQQSILLNMSTSSELLLAIISDVLDFSKIESGCFSLAPQWSNARDTVTFVLSEQKKIA
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHCC
DDKGLSLTLTSDIPEGELHYIDPSRLAQILFNLIGNAIKFTEHGHVHVSITYQHSSFRIS
CCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECEEEEE
VEDTGIGISSQQLSSLFSPFVQADSTITRRFGGTGLGLAITKRLVELMRGHISVESEPGK
EECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCEEEECCCCC
GSKFEVRLPVLTRVTNNQDHAAEDKYSQVPRTRYSVLVVEDNPTNQMVIQLILARQGHEV
CCEEEEEEEEEEEECCCCCCCCCHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEE
FIASNGEEAIGFVERGNDPIDIILMDVSMPVMDGITTTKYMRDANIKTPIVALTAHTSVE
EEECCCCHHEEHHHCCCCCEEEEEEECCCHHHCCCHHHHHHCCCCCCCCEEEEEECCCCC
DKFSCLDVGMNDFITKPVRTKEIIEAIDRLMLEV
CCHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA