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The map label for this gene is cheA [H]

Identifier: 218708843

GI number: 218708843

Start: 864736

End: 866937

Strand: Direct

Name: cheA [H]

Synonym: VS_0843

Alternate gene names: 218708843

Gene position: 864736-866937 (Clockwise)

Preceding gene: 218708842

Following gene: 218708844

Centisome position: 26.21

GC content: 46.5

Gene sequence:

>2202_bases
ATGAGCTACGATTTAGACGAAGATATTCTTCAGGACTTTTTAGTCGAAGCAGGAGAGATCCTCGAACTTCTATCAGAACA
ACTGGTAGAGCTAGAGAATAACCCTGACGACAAAGAACTACTAAACGCTATTTTCCGTGGTTTCCATACAGTAAAAGGTG
GTGCTGGTTTCCTAGCATTGACCGAGCTGGTGGATACTTGTCATGGTGCTGAGAATGTGTTCGACATTCTAAGAAATGGC
CAACGCAGTGTAACATCAGGACTGATGGATACGATGCTGCAGGCTTTAGATACAGTCAATGTACAGTTTAAAGCCGTGCA
AGATGAGGAAGCTTTAGTACCAGCAGACCAATCTTTACTGGATGAACTTCATCGCCTCTGTAAGCCAGAGTCTGAAGATG
AAGTTGTGGCAGTAGAAGCTCCAGCACCGGTTATCTCTGAGCCTATCGTTGCAGCTCCTGAGCCTGTTATTGCTCCGGAA
CCTACTGTTGAAAGTTCAAACATCAGTGCATCTTCCGTGGATGATATTTCTGAAGATGAATTTGAGCGTTTACTTGATGA
ACTTCACGGTAAGGGTGGTTCACCAACGACATCATCTGTAGACACACCAGCGCCAGCACCTGTGGCACCTCAGCCAGTAG
CTGCGAGTGGTGACATTACTGACGACGAATTTGAAAAGTTGTTAGATGAATTGCATGGTGCAGGTCAAAGCCCGACAGCT
GCAAGCTCAACGCCACCACCTCCTCCAGTCGCTCCGGTAGCCAAAGCACCAGTAAAGTCTGAAGGCGATGACCTAATGAC
TGATGCTGAGTTTGAGAGTTTACTTGACCAGTTACACGGTTCAGGTAACGGCCCTTCAATTGAAGAGTTGGATGCTGCGA
CTAAGCCTGTACAAGCGAAGCCTGAGCCTGTTGCGCCGAAAGTCGCTCCTAAACCACAGCCTGCTCCTGTTGCTGTAAAA
GCAGAGCCTAAGCCTAGCGTACCAGCAAAAGCTGAAGTTAAAGCGCCTGCGAAGAAGCAGCAAGCTGAAGCTACAGTTCG
TGTTGATACCTCAACACTGGATACCATCATGAACATGGTGGGTGAGCTAGTATTGGTTCGTAACCGCCTTGTTAGCTTAG
GTTTAAACAGCAACGACGAAGAAATGTCGAAAGCTGTCTCTAACTTAGATGTTGTTACTGCTGACCTACAAGGTGCAGTA
ATGAAGACGCGTATGCAGCCGATCAAGAAAGTATTTGGTCGATTCCCACGCGTTGTCCGTGACCTTGCTCGTACCTTGAA
GAAAGACATCGTTCTTGAAATGCGTGGCGAAGAAACGGATCTTGATAAAAACTTAGTAGAAGCACTTGCTGATCCCCTGA
TTCACTTGGTGAGAAACTCTGTAGATCATGGTATCGAAATGCCGGACGACCGTGTTGCTGCGGGAAAATCTAAAACCGGT
AAAGTGATTCTGTCTGCCTCTCAAGAAGGCGACCACATTGAACTGGCTATCGTTGATGATGGCGGCGGTATGGACCCTGA
TAAGCTTCGTGCTATCGCGGTTAAGCGCGGTCTGATGGATGATGATGCAGCGTCTCGCCTAACAAATAAAGAGTGTTTCA
ATCTAATCTTTGCTCCTGGCTTTTCAAGTAAAGAAAAGATCTCAGATATCTCTGGCCGTGGTGTAGGTATGGACGTTGTG
AAAACAGCGATCAACACACTGAATGGTTCAATTGATATCGACTCAGAGATGGGCCAAGGCACCAAGATTACCATTAAGGT
TCCTTTGACACTTGCGATCCTACCAACCTTAATGGTCGGTGTTGCGGGTCACCCGTTCGCATTGCCACTGGCTTCTGTAA
ATGAAATCTTCCACTTAGACCTAAGCCGCACAAACGTGGTTGATGGTCAGCTGACTATTATCGTTCGCGATAAGTCTATT
CCACTGTTCTACCTACAAAATTGGCTTACACCTAAAGAAGGTCTTGTTGAAGGACGTCAAGGTCATGGTCATGTTGTTAT
TGTGCAACTTGGTAGTCAACGTGTTGGTTTTGTTGTCGATGCGCTTATCGGCCAAGAAGAAGTGGTTATTAAGCCACTTG
ATAAGCTTCTTCAAGGCACGCCAGGAATGGCAGGTGCGACAATTACAAGTGACGGTCACATAGCATTGATTTTAGATGTG
CCGGACTTGTTGAAGCAGTACGCAGCTGCATCAAGAATTTAA

Upstream 100 bases:

>100_bases
AGAGGGTCCGATCATGAACCCAGAAGCTCGTGAGGATGCTGTTGCATCTCAAGATGAAGTCGACGATTTGTTATCCAGTC
TTGGATTTTAAAGGTAACGT

Downstream 100 bases:

>100_bases
CTTAAGGATAAATATGGCGATTAAAGTATTAGTCGTTGATGATTCGAGCTTCTTTCGTCGTAGAGTAAGCGAAATCATCA
ACTCGGAGGCTCGCCTAGAA

Product: Chemotaxis protein cheA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MSYDLDEDILQDFLVEAGEILELLSEQLVELENNPDDKELLNAIFRGFHTVKGGAGFLALTELVDTCHGAENVFDILRNG
QRSVTSGLMDTMLQALDTVNVQFKAVQDEEALVPADQSLLDELHRLCKPESEDEVVAVEAPAPVISEPIVAAPEPVIAPE
PTVESSNISASSVDDISEDEFERLLDELHGKGGSPTTSSVDTPAPAPVAPQPVAASGDITDDEFEKLLDELHGAGQSPTA
ASSTPPPPPVAPVAKAPVKSEGDDLMTDAEFESLLDQLHGSGNGPSIEELDAATKPVQAKPEPVAPKVAPKPQPAPVAVK
AEPKPSVPAKAEVKAPAKKQQAEATVRVDTSTLDTIMNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAV
MKTRMQPIKKVFGRFPRVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRVAAGKSKTG
KVILSASQEGDHIELAIVDDGGGMDPDKLRAIAVKRGLMDDDAASRLTNKECFNLIFAPGFSSKEKISDISGRGVGMDVV
KTAINTLNGSIDIDSEMGQGTKITIKVPLTLAILPTLMVGVAGHPFALPLASVNEIFHLDLSRTNVVDGQLTIIVRDKSI
PLFYLQNWLTPKEGLVEGRQGHGHVVIVQLGSQRVGFVVDALIGQEEVVIKPLDKLLQGTPGMAGATITSDGHIALILDV
PDLLKQYAAASRI

Sequences:

>Translated_733_residues
MSYDLDEDILQDFLVEAGEILELLSEQLVELENNPDDKELLNAIFRGFHTVKGGAGFLALTELVDTCHGAENVFDILRNG
QRSVTSGLMDTMLQALDTVNVQFKAVQDEEALVPADQSLLDELHRLCKPESEDEVVAVEAPAPVISEPIVAAPEPVIAPE
PTVESSNISASSVDDISEDEFERLLDELHGKGGSPTTSSVDTPAPAPVAPQPVAASGDITDDEFEKLLDELHGAGQSPTA
ASSTPPPPPVAPVAKAPVKSEGDDLMTDAEFESLLDQLHGSGNGPSIEELDAATKPVQAKPEPVAPKVAPKPQPAPVAVK
AEPKPSVPAKAEVKAPAKKQQAEATVRVDTSTLDTIMNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAV
MKTRMQPIKKVFGRFPRVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRVAAGKSKTG
KVILSASQEGDHIELAIVDDGGGMDPDKLRAIAVKRGLMDDDAASRLTNKECFNLIFAPGFSSKEKISDISGRGVGMDVV
KTAINTLNGSIDIDSEMGQGTKITIKVPLTLAILPTLMVGVAGHPFALPLASVNEIFHLDLSRTNVVDGQLTIIVRDKSI
PLFYLQNWLTPKEGLVEGRQGHGHVVIVQLGSQRVGFVVDALIGQEEVVIKPLDKLLQGTPGMAGATITSDGHIALILDV
PDLLKQYAAASRI
>Mature_732_residues
SYDLDEDILQDFLVEAGEILELLSEQLVELENNPDDKELLNAIFRGFHTVKGGAGFLALTELVDTCHGAENVFDILRNGQ
RSVTSGLMDTMLQALDTVNVQFKAVQDEEALVPADQSLLDELHRLCKPESEDEVVAVEAPAPVISEPIVAAPEPVIAPEP
TVESSNISASSVDDISEDEFERLLDELHGKGGSPTTSSVDTPAPAPVAPQPVAASGDITDDEFEKLLDELHGAGQSPTAA
SSTPPPPPVAPVAKAPVKSEGDDLMTDAEFESLLDQLHGSGNGPSIEELDAATKPVQAKPEPVAPKVAPKPQPAPVAVKA
EPKPSVPAKAEVKAPAKKQQAEATVRVDTSTLDTIMNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAVM
KTRMQPIKKVFGRFPRVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRVAAGKSKTGK
VILSASQEGDHIELAIVDDGGGMDPDKLRAIAVKRGLMDDDAASRLTNKECFNLIFAPGFSSKEKISDISGRGVGMDVVK
TAINTLNGSIDIDSEMGQGTKITIKVPLTLAILPTLMVGVAGHPFALPLASVNEIFHLDLSRTNVVDGQLTIIVRDKSIP
LFYLQNWLTPKEGLVEGRQGHGHVVIVQLGSQRVGFVVDALIGQEEVVIKPLDKLLQGTPGMAGATITSDGHIALILDVP
DLLKQYAAASRI

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=422, Percent_Identity=40.7582938388626, Blast_Score=286, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78172; Mature: 78041

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDLDEDILQDFLVEAGEILELLSEQLVELENNPDDKELLNAIFRGFHTVKGGAGFLAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
TELVDTCHGAENVFDILRNGQRSVTSGLMDTMLQALDTVNVQFKAVQDEEALVPADQSLL
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHH
DELHRLCKPESEDEVVAVEAPAPVISEPIVAAPEPVIAPEPTVESSNISASSVDDISEDE
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
FERLLDELHGKGGSPTTSSVDTPAPAPVAPQPVAASGDITDDEFEKLLDELHGAGQSPTA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
ASSTPPPPPVAPVAKAPVKSEGDDLMTDAEFESLLDQLHGSGNGPSIEELDAATKPVQAK
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
PEPVAPKVAPKPQPAPVAVKAEPKPSVPAKAEVKAPAKKQQAEATVRVDTSTLDTIMNMV
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHCCEEEEECHHHHHHHHHHH
GELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAVMKTRMQPIKKVFGRFPRVVR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRVAAGKSKTG
HHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC
KVILSASQEGDHIELAIVDDGGGMDPDKLRAIAVKRGLMDDDAASRLTNKECFNLIFAPG
EEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCHHHHHEEECCC
FSSKEKISDISGRGVGMDVVKTAINTLNGSIDIDSEMGQGTKITIKVPLTLAILPTLMVG
CCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCHHHHHHHHHHHH
VAGHPFALPLASVNEIFHLDLSRTNVVDGQLTIIVRDKSIPLFYLQNWLTPKEGLVEGRQ
CCCCCCCCCHHHHHHHEEEECCCCEEECCEEEEEEECCCCCHHHHHHCCCCHHHHCCCCC
GHGHVVIVQLGSQRVGFVVDALIGQEEVVIKPLDKLLQGTPGMAGATITSDGHIALILDV
CCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECC
PDLLKQYAAASRI
HHHHHHHHHHCCC
>Mature Secondary Structure 
SYDLDEDILQDFLVEAGEILELLSEQLVELENNPDDKELLNAIFRGFHTVKGGAGFLAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
TELVDTCHGAENVFDILRNGQRSVTSGLMDTMLQALDTVNVQFKAVQDEEALVPADQSLL
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHH
DELHRLCKPESEDEVVAVEAPAPVISEPIVAAPEPVIAPEPTVESSNISASSVDDISEDE
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
FERLLDELHGKGGSPTTSSVDTPAPAPVAPQPVAASGDITDDEFEKLLDELHGAGQSPTA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
ASSTPPPPPVAPVAKAPVKSEGDDLMTDAEFESLLDQLHGSGNGPSIEELDAATKPVQAK
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
PEPVAPKVAPKPQPAPVAVKAEPKPSVPAKAEVKAPAKKQQAEATVRVDTSTLDTIMNMV
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHCCEEEEECHHHHHHHHHHH
GELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAVMKTRMQPIKKVFGRFPRVVR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRVAAGKSKTG
HHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC
KVILSASQEGDHIELAIVDDGGGMDPDKLRAIAVKRGLMDDDAASRLTNKECFNLIFAPG
EEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCHHHHHEEECCC
FSSKEKISDISGRGVGMDVVKTAINTLNGSIDIDSEMGQGTKITIKVPLTLAILPTLMVG
CCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCHHHHHHHHHHHH
VAGHPFALPLASVNEIFHLDLSRTNVVDGQLTIIVRDKSIPLFYLQNWLTPKEGLVEGRQ
CCCCCCCCCHHHHHHHEEEECCCCEEECCEEEEEEECCCCCHHHHHHCCCCHHHHCCCCC
GHGHVVIVQLGSQRVGFVVDALIGQEEVVIKPLDKLLQGTPGMAGATITSDGHIALILDV
CCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECC
PDLLKQYAAASRI
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377 [H]