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The map label for this gene is glmS [H]

Identifier: 218708432

GI number: 218708432

Start: 399148

End: 400980

Strand: Direct

Name: glmS [H]

Synonym: VS_0394

Alternate gene names: 218708432

Gene position: 399148-400980 (Clockwise)

Preceding gene: 218708431

Following gene: 218708438

Centisome position: 12.1

GC content: 46.75

Gene sequence:

>1833_bases
ATGTGTGGAATTGTTGGTGCAGTAGCACAGCGTGATGTAGCCGAAATTTTAGTAGAAGGCCTTCGCCGCCTAGAATACCG
AGGCTACGATTCAGCGGGTGTCGCTGTAGTTGATTGCGAATCTAACCTAACTCGTGTACGCCGCCTTGGTAAAGTACAAG
AGCTAGCAGACGCAGTCGATCAACAACATGTTATTGGCGGTACTGGTATCGCTCATACACGTTGGGCGACACACGGTGAG
CCTTCTGAAGCAAACGCACACCCACACATGTCTGGTGATATTGCTGTTGTACACAATGGTATTATCGAAAACCACGAAGC
ACTGCGTGCTCTTCTTCAAGAGCGTGGTTATGTGTTTACTTCACAAACGGATACTGAAGTTATCGCTCATCTTGTTGAGT
GGGAACTTCGCACGTCAGCTTCTTTGGTTGAAGCTCTGCAAAAAACAGCAAAACAATTAGACGGTGCATACGGCACAGTG
GCGGTTGATCGTAAAGATCCTAGCCGTATCGTTGTTGCTCGTTCTGGTAGCCCAATCGTTATCGGTTTTGGTGTCGGCGA
GAACTTCCTTGCTTCTGACCAACTAGCGCTATTAAGCGTAACTCGTCGCTTCATGTACTTAGAAGAGGGTGATGTTGCTG
AGGTGACTCGTCGTGATGTAACAGTATTTGATGTAGCGGGCGAGCGTGTAGAGCGTGAAATCGTTGAATCAAACGCAGAA
CACGATGCAGGTGATAAAGGTCAATACCGTCACTTCATGCAGAAAGAGGTCTTTGAGCAGCCAACAGCGCTAATCAATAC
AATGGAAGGTCGTATCTCTGAAACGTCTGTTATCACTAACGCAATTGGTGTTAAAACCGAAGAGATTCTAAGCAAGGTAG
AGCATGTGCAGATCATCGCATGTGGTACGTCTTACAACTCTGGCATGGTTGCACGTTACTGGTTTGAGTCTCTAGCAGGC
GTAAGCTGTGACGTAGAGATTGCCTCTGAATTCCGTTACCGTGACTTCGTTGTTCGCCCGAATAGCCTATTGGTAACTAT
CTCCCAGTCAGGTGAAACGGCCGATACGCTTGCTGCACTTCGCTTGGCAAAAGAGAAGGGATACATGTCCGCAATGACTA
TCTGTAACGTTGCGGGTTCTTCTCTGGTTCGTGAATCTGATTTTGCCTTTATGACTCGCGCAGGAACAGAGATCGGTGTG
GCTTCGACTAAAGCTTTCACAACCCAACTAGCTGCAATGCTGATGATGGTAACTTCAATTGGTCACCTACAAGGTCGTAT
CAATGAAGAGAAAGAAGCTGAAATCGTTCAAGCACTGCATCAACTGCCTGCTGATATTGAAAAAGCATTGGCATTTGATA
AAGAAATTGAAGCACTAGCACCTGATTTTGCTGATAAGCACCACACATTGTTCCTAGGTCGTGGCGAGTTCTACCCAATC
GCAATGGAAGCGTCTCTGAAGCTGAAAGAGATCTCTTACATTCATGCAGAAGCATACGCGGCAGGTGAGCTTAAGCACGG
TCCTTTGGCTCTTATCGATGCAGATATGCCAGTAGTCGTTATTGCACCAAGCAACGACTTGCTAGAGAAGCTGAAATCAA
ACGTTGAAGAAGTACGTGCTCGTGGCGGTCTACTTTACGTATTCGCAGATGAAGACGCTGGCTTTGAAAGCGATGAGAAC
ATGAAGATCATCAAGATGCCTCACGTAAGTGAAGTAACAGCACCTATCTACTACACAGTACCGATGCAGCTGTTGTCTTA
CCACGTAGCATTAATCAAAGGGACCGACGTTGACCAACCTCGTAACCTTGCGAAATCGGTAACGGTTGAGTAA

Upstream 100 bases:

>100_bases
TTTAAGTATTATGCATTTACCTTCCTATAATTGATCTTGATAAAGATCTGGCCTTTGCTTGCTGCCAATAGGAATAAAAC
GAAATTGATGGAGTGAAACT

Downstream 100 bases:

>100_bases
TCGCCAACCTATCACAGAAAATTAGATAATAAGAAGCCCATCCTGTGATGGGCTTTTTTGTGTCTGTGAGTTAACGATTC
GTGTTAGAGCTAGCTGTAGC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDCESNLTRVRRLGKVQELADAVDQQHVIGGTGIAHTRWATHGE
PSEANAHPHMSGDIAVVHNGIIENHEALRALLQERGYVFTSQTDTEVIAHLVEWELRTSASLVEALQKTAKQLDGAYGTV
AVDRKDPSRIVVARSGSPIVIGFGVGENFLASDQLALLSVTRRFMYLEEGDVAEVTRRDVTVFDVAGERVEREIVESNAE
HDAGDKGQYRHFMQKEVFEQPTALINTMEGRISETSVITNAIGVKTEEILSKVEHVQIIACGTSYNSGMVARYWFESLAG
VSCDVEIASEFRYRDFVVRPNSLLVTISQSGETADTLAALRLAKEKGYMSAMTICNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLAAMLMMVTSIGHLQGRINEEKEAEIVQALHQLPADIEKALAFDKEIEALAPDFADKHHTLFLGRGEFYPI
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVIAPSNDLLEKLKSNVEEVRARGGLLYVFADEDAGFESDEN
MKIIKMPHVSEVTAPIYYTVPMQLLSYHVALIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDCESNLTRVRRLGKVQELADAVDQQHVIGGTGIAHTRWATHGE
PSEANAHPHMSGDIAVVHNGIIENHEALRALLQERGYVFTSQTDTEVIAHLVEWELRTSASLVEALQKTAKQLDGAYGTV
AVDRKDPSRIVVARSGSPIVIGFGVGENFLASDQLALLSVTRRFMYLEEGDVAEVTRRDVTVFDVAGERVEREIVESNAE
HDAGDKGQYRHFMQKEVFEQPTALINTMEGRISETSVITNAIGVKTEEILSKVEHVQIIACGTSYNSGMVARYWFESLAG
VSCDVEIASEFRYRDFVVRPNSLLVTISQSGETADTLAALRLAKEKGYMSAMTICNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLAAMLMMVTSIGHLQGRINEEKEAEIVQALHQLPADIEKALAFDKEIEALAPDFADKHHTLFLGRGEFYPI
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVIAPSNDLLEKLKSNVEEVRARGGLLYVFADEDAGFESDEN
MKIIKMPHVSEVTAPIYYTVPMQLLSYHVALIKGTDVDQPRNLAKSVTVE
>Mature_610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDCESNLTRVRRLGKVQELADAVDQQHVIGGTGIAHTRWATHGE
PSEANAHPHMSGDIAVVHNGIIENHEALRALLQERGYVFTSQTDTEVIAHLVEWELRTSASLVEALQKTAKQLDGAYGTV
AVDRKDPSRIVVARSGSPIVIGFGVGENFLASDQLALLSVTRRFMYLEEGDVAEVTRRDVTVFDVAGERVEREIVESNAE
HDAGDKGQYRHFMQKEVFEQPTALINTMEGRISETSVITNAIGVKTEEILSKVEHVQIIACGTSYNSGMVARYWFESLAG
VSCDVEIASEFRYRDFVVRPNSLLVTISQSGETADTLAALRLAKEKGYMSAMTICNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLAAMLMMVTSIGHLQGRINEEKEAEIVQALHQLPADIEKALAFDKEIEALAPDFADKHHTLFLGRGEFYPI
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVIAPSNDLLEKLKSNVEEVRARGGLLYVFADEDAGFESDEN
MKIIKMPHVSEVTAPIYYTVPMQLLSYHVALIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=37.4269005847953, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=36.5747460087083, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI29570798, Length=259, Percent_Identity=25.8687258687259, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=70.9836065573771, Blast_Score=913, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=229, Percent_Identity=28.82096069869, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=37.4133949191686, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=36.8909512761021, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=36.8909512761021, Blast_Score=271, Evalue=8e-73,
Organism=Saccharomyces cerevisiae, GI6322745, Length=463, Percent_Identity=36.7170626349892, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=30.8924485125858, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=39.2156862745098, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=36.0869565217391, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI28573187, Length=267, Percent_Identity=26.9662921348315, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24659598, Length=141, Percent_Identity=30.4964539007092, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66810; Mature: 66810

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDCESNLTRVRRLGKVQELADAVD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
QQHVIGGTGIAHTRWATHGEPSEANAHPHMSGDIAVVHNGIIENHEALRALLQERGYVFT
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCEEEE
SQTDTEVIAHLVEWELRTSASLVEALQKTAKQLDGAYGTVAVDRKDPSRIVVARSGSPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCCEE
IGFGVGENFLASDQLALLSVTRRFMYLEEGDVAEVTRRDVTVFDVAGERVEREIVESNAE
EEECCCCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHCCEEEEECCHHHHHHHHHHCCCC
HDAGDKGQYRHFMQKEVFEQPTALINTMEGRISETSVITNAIGVKTEEILSKVEHVQIIA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCEEEEEE
CGTSYNSGMVARYWFESLAGVSCDVEIASEFRYRDFVVRPNSLLVTISQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCEEEEHHHHCCCCEEEEECCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMSAMTICNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLAAMLMMVTSI
HHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
GHLQGRINEEKEAEIVQALHQLPADIEKALAFDKEIEALAPDFADKHHTLFLGRGEFYPI
HHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEE
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVIAPSNDLLEKLKSNVEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGLLYVFADEDAGFESDENMKIIKMPHVSEVTAPIYYTVPMQLLSYHVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHEEEEECCCCCCC
RNLAKSVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDCESNLTRVRRLGKVQELADAVD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
QQHVIGGTGIAHTRWATHGEPSEANAHPHMSGDIAVVHNGIIENHEALRALLQERGYVFT
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCEEEE
SQTDTEVIAHLVEWELRTSASLVEALQKTAKQLDGAYGTVAVDRKDPSRIVVARSGSPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCCEE
IGFGVGENFLASDQLALLSVTRRFMYLEEGDVAEVTRRDVTVFDVAGERVEREIVESNAE
EEECCCCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHCCEEEEECCHHHHHHHHHHCCCC
HDAGDKGQYRHFMQKEVFEQPTALINTMEGRISETSVITNAIGVKTEEILSKVEHVQIIA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCEEEEEE
CGTSYNSGMVARYWFESLAGVSCDVEIASEFRYRDFVVRPNSLLVTISQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCEEEEHHHHCCCCEEEEECCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMSAMTICNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLAAMLMMVTSI
HHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
GHLQGRINEEKEAEIVQALHQLPADIEKALAFDKEIEALAPDFADKHHTLFLGRGEFYPI
HHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEE
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVIAPSNDLLEKLKSNVEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGLLYVFADEDAGFESDENMKIIKMPHVSEVTAPIYYTVPMQLLSYHVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHEEEEECCCCCCC
RNLAKSVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]