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The map label for this gene is gcp

Identifier: 218708438

GI number: 218708438

Start: 407585

End: 408601

Strand: Direct

Name: gcp

Synonym: VS_0401

Alternate gene names: 218708438

Gene position: 407585-408601 (Clockwise)

Preceding gene: 218708432

Following gene: 218708439

Centisome position: 12.35

GC content: 49.46

Gene sequence:

>1017_bases
ATGCGCATTATTGGTATTGAAACCTCTTGTGATGAAACAGGAATCGCAATTTATGATGATGAGCAAGGGCTGCTTTCTCA
TCAGTTATACAGCCAAGTAAAGCTGCACGCCGATTACGGTGGTGTGGTACCTGAGCTAGCGTCGCGTGACCACGTAAAAA
AAACCATTCCACTGATTAAAGCGGCATTGGCAGAAGCGAACCTAACGTCGAAAGATATTGATGGCGTGGCTTACACGGCT
GGCCCTGGTTTGGTTGGTGCATTGCTTGTGGGCGCAACGATTGGTCGCAGTATTGCCTATGCGTGGGGCGTGCCTGCTGT
GCCAGTGCACCATATGGAAGGTCACCTTCTTGCGCCAATGCTAGAAGATAATCCTCCACCATTCCCATTTGTTGCTCTGC
TGGTTTCTGGCGGTCATACCATGATGGTAGAAGTGAAAGGCATTGGTGAATACCGAATTCTTGGTGAATCGATTGATGAT
GCGGCGGGTGAAGCGTTTGATAAAACCGCGAAGCTAATGGGCTTAGATTACCCAGGTGGTCCACTGCTATCTCGACTCGC
AGAAAAAGGCACGCCAGGTCGTTTTAAGTTCCCACGTCCAATGACCGATCGTCCGGGTCTAGATATGAGCTTTTCGGGCT
TGAAAACGTTCGCGGCAAATACCATTCGTGCTAATGACAATGATGACCAAACTCGTGCTGACATCGCTTATGCGTTCCAA
GAAGCGGTTTGTGCGACCTTGGTAATCAAGTGTAAGCGTGCGTTGGTAGAGACGGGTATGAAACGTATCGTGATTGCTGG
CGGTGTGAGTGCCAACAAACAACTACGAGTTGAGCTTGAAGCATTAGCCAAGAAAATCGGTGGAGAGGTGTACTACCCAC
GCACTGAGTTCTGTACAGATAACGGTGCGATGATCGCTTATGCGGGCATGCAGCGCCTGAAGAATGGTGAAACGGCTGAT
TTATCTGTCCATGCCACACCGCGTTGGCCAATTGACCAGCTAGAGCCGATTGTTTAA

Upstream 100 bases:

>100_bases
ACTTTGTCGATTATAGTCTGTACAATATTTGTTTGAAGAGCTTAGGCAGGGTAATATTGCGCTAATTTCCCATTTTAGAC
GAAAGCGTGCCGAGAAAATT

Downstream 100 bases:

>100_bases
TCATAACCAATCGCCAAATAAACCATAGTATTTCGATAAACGGTCGCTGAGTGCGGCCGTTTTTATATCCTAGCTTACCG
ACTGTATGTCGATAAATAAT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRIIGIETSCDETGIAIYDDEQGLLSHQLYSQVKLHADYGGVVPELASRDHVKKTIPLIKAALAEANLTSKDIDGVAYTA
GPGLVGALLVGATIGRSIAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVALLVSGGHTMMVEVKGIGEYRILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLSRLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFAANTIRANDNDDQTRADIAYAFQ
EAVCATLVIKCKRALVETGMKRIVIAGGVSANKQLRVELEALAKKIGGEVYYPRTEFCTDNGAMIAYAGMQRLKNGETAD
LSVHATPRWPIDQLEPIV

Sequences:

>Translated_338_residues
MRIIGIETSCDETGIAIYDDEQGLLSHQLYSQVKLHADYGGVVPELASRDHVKKTIPLIKAALAEANLTSKDIDGVAYTA
GPGLVGALLVGATIGRSIAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVALLVSGGHTMMVEVKGIGEYRILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLSRLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFAANTIRANDNDDQTRADIAYAFQ
EAVCATLVIKCKRALVETGMKRIVIAGGVSANKQLRVELEALAKKIGGEVYYPRTEFCTDNGAMIAYAGMQRLKNGETAD
LSVHATPRWPIDQLEPIV
>Mature_338_residues
MRIIGIETSCDETGIAIYDDEQGLLSHQLYSQVKLHADYGGVVPELASRDHVKKTIPLIKAALAEANLTSKDIDGVAYTA
GPGLVGALLVGATIGRSIAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVALLVSGGHTMMVEVKGIGEYRILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLSRLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFAANTIRANDNDDQTRADIAYAFQ
EAVCATLVIKCKRALVETGMKRIVIAGGVSANKQLRVELEALAKKIGGEVYYPRTEFCTDNGAMIAYAGMQRLKNGETAD
LSVHATPRWPIDQLEPIV

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=337, Percent_Identity=31.7507418397626, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI8923380, Length=338, Percent_Identity=31.0650887573964, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=78.1437125748503, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17557464, Length=334, Percent_Identity=30.5389221556886, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71995670, Length=344, Percent_Identity=33.4302325581395, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320099, Length=367, Percent_Identity=31.8801089918256, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322891, Length=349, Percent_Identity=29.7994269340974, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129063, Length=346, Percent_Identity=32.3699421965318, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21357207, Length=349, Percent_Identity=30.0859598853868, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_VIBSL (B7VIH2)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416059.1
- ProteinModelPortal:   B7VIH2
- SMR:   B7VIH2
- MEROPS:   M22.001
- GeneID:   7160037
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0401
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36304; Mature: 36304

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIGIETSCDETGIAIYDDEQGLLSHQLYSQVKLHADYGGVVPELASRDHVKKTIPLIK
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
AALAEANLTSKDIDGVAYTAGPGLVGALLVGATIGRSIAYAWGVPAVPVHHMEGHLLAPM
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEECHH
LEDNPPPFPFVALLVSGGHTMMVEVKGIGEYRILGESIDDAAGEAFDKTAKLMGLDYPGG
HCCCCCCCHHEEHEECCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHEECCCCCC
PLLSRLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFAANTIRANDNDDQTRADIAYAFQ
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHCEEECCCCCCHHHHHHHHHHH
EAVCATLVIKCKRALVETGMKRIVIAGGVSANKQLRVELEALAKKIGGEVYYPRTEFCTD
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEHHHHHHHHCCCEECCCHHEECC
NGAMIAYAGMQRLKNGETADLSVHATPRWPIDQLEPIV
CCCEEEHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCC
>Mature Secondary Structure
MRIIGIETSCDETGIAIYDDEQGLLSHQLYSQVKLHADYGGVVPELASRDHVKKTIPLIK
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
AALAEANLTSKDIDGVAYTAGPGLVGALLVGATIGRSIAYAWGVPAVPVHHMEGHLLAPM
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEECHH
LEDNPPPFPFVALLVSGGHTMMVEVKGIGEYRILGESIDDAAGEAFDKTAKLMGLDYPGG
HCCCCCCCHHEEHEECCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHEECCCCCC
PLLSRLAEKGTPGRFKFPRPMTDRPGLDMSFSGLKTFAANTIRANDNDDQTRADIAYAFQ
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHCEEECCCCCCHHHHHHHHHHH
EAVCATLVIKCKRALVETGMKRIVIAGGVSANKQLRVELEALAKKIGGEVYYPRTEFCTD
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEHHHHHHHHCCCEECCCHHEECC
NGAMIAYAGMQRLKNGETADLSVHATPRWPIDQLEPIV
CCCEEEHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA