Click here to switch to the map view.

The map label for this gene is frdA [H]

Identifier: 218708310

GI number: 218708310

Start: 243229

End: 245052

Strand: Reverse

Name: frdA [H]

Synonym: VS_0248

Alternate gene names: 218708310

Gene position: 245052-243229 (Counterclockwise)

Preceding gene: 218708312

Following gene: 218708309

Centisome position: 7.43

GC content: 49.29

Gene sequence:

>1824_bases
GTGAAGACAATTACCACAGATATCGCAGTCATCGGCGCAGGCGGCGCTGGTCTTCGTACAGCTATCGCTGCGGCTGAAGC
TAATCCTGAATTGGAAGTAGCACTGATTTCTAAAGTTTACCCAATGCGTTCGCACACGGTAGCGGCAGAAGGCGGTTCAG
CAGCAGTAATTAAAGACGAAGATAGCCTAGATAACCACTTCAACGATACTGTTGGCGGGGGCGACTGGCTATGTGAACAG
GATGTTGTTGAATACTTTGTTGAAAACTCGACTCGCGAAATGATCCAAATGGAACAATGGGGCTGCCCATGGAGTCGTAA
AGAAAACGGTGAAGTAAACGTACGCCGATTCGGCGGTATGAAGGTAGAAAGAACGTGGTTCGCAGCGGATAAAACCGGCT
TCCACATGCTTCATACTCTGTTCCAGACTTCGATGAAGTACGACACAATCAAACGATTTGATGAGTACTTTGTGGTGGAT
TTGATCGTTGAAGATGGCGAAGTACAAGGCCTAATCGCGATTCATATGTCTGAAGGTGAGCTTGTTACCATCAAAGCGAA
ATCTGTTGTTCTAGCAACCGGTGGCGCAGGTCGTGTTTACCACTGTAATACCAACGGCGGCATCGTAACTGGCGACGGTA
TGGCAATGGCTTATCGCCACGGTGTACCACTGCGTGACATGGAGTTCGTTCAATACCACCCAACAGGCCTACCGGGTACT
GGCATCTTGATGACCGAAGGTTGTCGTGGTGAAGGCGGTATCATCGTCAACAAGAACGGCTACCGTTACCTGCAAGATTA
CGGCATGGGCCCTGAAACTCCAGTAGGCGAGCCGAAAAACAAATACATGGAACTGGGTCCTCGTGACAAAGTTTCTCAAG
CATTCTGGCACGAGCAGCAGAAAGGCAACACCATCAAGCACCCGCTTGGTGATGTCGTACACCTTGACCTTCGCCACCTT
GGTGAAGAGTACCTGCAAGAACGTCTGCCGTTTATCTGTGAGCTTGCAAAAGCATACGTAAATGTAGACCCAGCAAAAGA
GCCAATCCCAATTCGCCCAACCGTTCACTACACCATGGGTGGTATCGAAACTAACGGTACTTGTGAGACTCGCATTAAAG
GCCTATTCGCCGTTGGTGAATGTGCTTCAGTTGGCCTACACGGTGCAAACCGCCTAGGTTCTAACTCACTGGCTGAGTTC
GTAGTTTTCGGCCGCGTAGCCGGTGAACAAGCCGTGAAACGCGCAGCTGAATTCAAAGGCTGGAACGAAGAGTCTATTGC
TAAGCAAGTGAAAGCGGTTGAAGATCGCATCGCTGGCATCTTGGCTCAAGAAGGCGATGAGAACTGGGCTGATATCCGTA
CTGAAATGGGTCACACCATGGAAGCGGGTTGTGGTATCTACCGTCAGGAAGACTTGATGCAAGAAACCATCGACAAAATC
ACTGAACTGAAAGCTCGCTACAAGAAGATCAGCATTAAAGACAAAGGCAAAGTGTTCAACACTGACCTACTTTACGCTAT
CGAAGTGGGTTACGGCCTTGAAGTTGCCGAAGCGATGGTTCACTCCGCGATCCTTCGTAAAGAGTCTCGCGGTGCACACC
AACGTCTAGACGACAACTGCACAGAACGTGATGACGTGAACTTCCTGAAACATTCTCTATCTTTCTACAACGAAGATGCA
GCACCAACTATCGACTACAGCGGCGTTAAGATTACTAAATCTCAACCTAAAGCTCGTCTATACGGTGAAGCAGCCGAGAA
AGCCGCGGCTGCTGAAAAAGCGGCAGAAGAGAATGCGAAGAAGAGCGAAGAGGAGCAAGCATAA

Upstream 100 bases:

>100_bases
TACGTACTATTAATTAGTAAGTACTGCCAATTAGTAAGTACTACCAATAAGCTTTTTATAATAACAAGCGGAATACTCCG
CATCACACTGGAGAATAACT

Downstream 100 bases:

>100_bases
TGTCAGCGAATCGAATCCAAAAAATTGAAATCCTGCGTTATGACCCTGAGCACGATGCAGAGCCTCACTTTCAAACCTTT
GAAGTTCCATTTGATGAAAC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEVALISKVYPMRSHTVAAEGGSAAVIKDEDSLDNHFNDTVGGGDWLCEQ
DVVEYFVENSTREMIQMEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYDTIKRFDEYFVVD
LIVEDGEVQGLIAIHMSEGELVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHEQQKGNTIKHPLGDVVHLDLRHL
GEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETNGTCETRIKGLFAVGECASVGLHGANRLGSNSLAEF
VVFGRVAGEQAVKRAAEFKGWNEESIAKQVKAVEDRIAGILAQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQETIDKI
TELKARYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDNCTERDDVNFLKHSLSFYNEDA
APTIDYSGVKITKSQPKARLYGEAAEKAAAAEKAAEENAKKSEEEQA

Sequences:

>Translated_607_residues
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEVALISKVYPMRSHTVAAEGGSAAVIKDEDSLDNHFNDTVGGGDWLCEQ
DVVEYFVENSTREMIQMEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYDTIKRFDEYFVVD
LIVEDGEVQGLIAIHMSEGELVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHEQQKGNTIKHPLGDVVHLDLRHL
GEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETNGTCETRIKGLFAVGECASVGLHGANRLGSNSLAEF
VVFGRVAGEQAVKRAAEFKGWNEESIAKQVKAVEDRIAGILAQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQETIDKI
TELKARYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDNCTERDDVNFLKHSLSFYNEDA
APTIDYSGVKITKSQPKARLYGEAAEKAAAAEKAAEENAKKSEEEQA
>Mature_607_residues
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEVALISKVYPMRSHTVAAEGGSAAVIKDEDSLDNHFNDTVGGGDWLCEQ
DVVEYFVENSTREMIQMEQWGCPWSRKENGEVNVRRFGGMKVERTWFAADKTGFHMLHTLFQTSMKYDTIKRFDEYFVVD
LIVEDGEVQGLIAIHMSEGELVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHEQQKGNTIKHPLGDVVHLDLRHL
GEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMGGIETNGTCETRIKGLFAVGECASVGLHGANRLGSNSLAEF
VVFGRVAGEQAVKRAAEFKGWNEESIAKQVKAVEDRIAGILAQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQETIDKI
TELKARYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDNCTERDDVNFLKHSLSFYNEDA
APTIDYSGVKITKSQPKARLYGEAAEKAAAAEKAAEENAKKSEEEQA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=529, Percent_Identity=39.3194706994329, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=73.0240549828179, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=540, Percent_Identity=41.1111111111111, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=32.129963898917, Blast_Score=248, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17505833, Length=536, Percent_Identity=39.365671641791, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17550100, Length=540, Percent_Identity=38.3333333333333, Blast_Score=358, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI71986328, Length=432, Percent_Identity=26.3888888888889, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322701, Length=567, Percent_Identity=39.6825396825397, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322416, Length=567, Percent_Identity=39.3298059964727, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=25.6673511293634, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137288, Length=578, Percent_Identity=38.0622837370242, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655642, Length=578, Percent_Identity=38.0622837370242, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655647, Length=578, Percent_Identity=38.0622837370242, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24663005, Length=541, Percent_Identity=37.8927911275416, Blast_Score=347, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66943; Mature: 66943

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEVALISKVYPMRSHTVAAEGGSAAVIKDE
CCEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEHHHHCCCCCCEEEECCCCEEEEECC
DSLDNHFNDTVGGGDWLCEQDVVEYFVENSTREMIQMEQWGCPWSRKENGEVNVRRFGGM
CCHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KVERTWFAADKTGFHMLHTLFQTSMKYDTIKRFDEYFVVDLIVEDGEVQGLIAIHMSEGE
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEEEEEEEECCCC
LVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
EEEEEECEEEEEECCCCEEEEECCCCCEEECCCEEEHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHEQQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KGNTIKHPLGDVVHLDLRHLGEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETNGTCETRIKGLFAVGECASVGLHGANRLGSNSLAEFVVFGRVAGEQAVKRAAEFKG
CCCCCCCHHHHHHHEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
WNEESIAKQVKAVEDRIAGILAQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQETIDKI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHH
TELKARYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDNC
HHHHHHHHEECCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCC
TERDDVNFLKHSLSFYNEDAAPTIDYSGVKITKSQPKARLYGEAAEKAAAAEKAAEENAK
CCCHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KSEEEQA
CCHHHCC
>Mature Secondary Structure
MKTITTDIAVIGAGGAGLRTAIAAAEANPELEVALISKVYPMRSHTVAAEGGSAAVIKDE
CCEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEHHHHCCCCCCEEEECCCCEEEEECC
DSLDNHFNDTVGGGDWLCEQDVVEYFVENSTREMIQMEQWGCPWSRKENGEVNVRRFGGM
CCHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KVERTWFAADKTGFHMLHTLFQTSMKYDTIKRFDEYFVVDLIVEDGEVQGLIAIHMSEGE
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEEEEEEEECCCC
LVTIKAKSVVLATGGAGRVYHCNTNGGIVTGDGMAMAYRHGVPLRDMEFVQYHPTGLPGT
EEEEEECEEEEEECCCCEEEEECCCCCEEECCCEEEHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGIIVNKNGYRYLQDYGMGPETPVGEPKNKYMELGPRDKVSQAFWHEQQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KGNTIKHPLGDVVHLDLRHLGEEYLQERLPFICELAKAYVNVDPAKEPIPIRPTVHYTMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETNGTCETRIKGLFAVGECASVGLHGANRLGSNSLAEFVVFGRVAGEQAVKRAAEFKG
CCCCCCCHHHHHHHEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
WNEESIAKQVKAVEDRIAGILAQEGDENWADIRTEMGHTMEAGCGIYRQEDLMQETIDKI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHH
TELKARYKKISIKDKGKVFNTDLLYAIEVGYGLEVAEAMVHSAILRKESRGAHQRLDDNC
HHHHHHHHEECCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCC
TERDDVNFLKHSLSFYNEDAAPTIDYSGVKITKSQPKARLYGEAAEKAAAAEKAAEENAK
CCCHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KSEEEQA
CCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]