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The map label for this gene is frdB [H]

Identifier: 218708309

GI number: 218708309

Start: 242465

End: 243229

Strand: Reverse

Name: frdB [H]

Synonym: VS_0247

Alternate gene names: 218708309

Gene position: 243229-242465 (Counterclockwise)

Preceding gene: 218708310

Following gene: 218708308

Centisome position: 7.37

GC content: 46.93

Gene sequence:

>765_bases
ATGTCAGCGAATCGAATCCAAAAAATTGAAATCCTGCGTTATGACCCTGAGCACGATGCAGAGCCTCACTTTCAAACCTT
TGAAGTTCCATTTGATGAAACCATGTCGGTACTTGATGCGATTGGTTACATCAAAGATAACCTAGATAAAGACCTGTCTT
ACCGTTGGTCTTGTCGTATGGCGATTTGTGGTTCTTGCGGCATCATGGTTGATGGCGTGCCAAAACTGGCATGTAAGAGC
TTCTTACGTGACTACCCGAACGGCTTCAAGATCGAGCCTTTAGCTAACTTCCCAATCGAGAAAGATTTGATCGTCGACAT
GACGCCGTTTATCGAGCGCCTTGAAGCAATCAAACCTTACATCATTGGTAACGACCGTAAGCCAGAAGACGGCACTAACA
TCCAAACTCCAGAGCAAATGGCGAAGTACAAACAGTTCGCTGGCTGCATCAACTGTGGTTTGTGTTACGCAGCGTGTCCT
CAGTTTGGTCTAAACCCTGAGTTCATTGGCCCTGCGGCACTTGCTCTTGCTCACCGCTACAACCTAGATAGCCGTGACAA
TGGTAAAGCTGAGCGCATGAAGCTTATCAATGGCGACAACGGCGCTTGGGGCTGTACGTTTGTAGGTTACTGTTCTGACG
TTTGTCCGAAGAAAGTAGATCCAGCAGCAGCTGTAAACCAAGGCAAAGTTGAGTCTTCAATGGACTTCGTTATCTCGATG
TTCAAGCCTGATGGATCGCAAGTAAAAACAGCAGAGGAGGCATAA

Upstream 100 bases:

>100_bases
AACCTAAAGCTCGTCTATACGGTGAAGCAGCCGAGAAAGCCGCGGCTGCTGAAAAAGCGGCAGAAGAGAATGCGAAGAAG
AGCGAAGAGGAGCAAGCATA

Downstream 100 bases:

>100_bases
TATGAGCAATCGTAAGCCTTATGTTCGTGATATGAAGAGAACATGGTGGAGCAACCATCCGTTCTACCGCTTCTACATGC
TACGTGAAGCGACTGTACTG

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSANRIQKIEILRYDPEHDAEPHFQTFEVPFDETMSVLDAIGYIKDNLDKDLSYRWSCRMAICGSCGIMVDGVPKLACKS
FLRDYPNGFKIEPLANFPIEKDLIVDMTPFIERLEAIKPYIIGNDRKPEDGTNIQTPEQMAKYKQFAGCINCGLCYAACP
QFGLNPEFIGPAALALAHRYNLDSRDNGKAERMKLINGDNGAWGCTFVGYCSDVCPKKVDPAAAVNQGKVESSMDFVISM
FKPDGSQVKTAEEA

Sequences:

>Translated_254_residues
MSANRIQKIEILRYDPEHDAEPHFQTFEVPFDETMSVLDAIGYIKDNLDKDLSYRWSCRMAICGSCGIMVDGVPKLACKS
FLRDYPNGFKIEPLANFPIEKDLIVDMTPFIERLEAIKPYIIGNDRKPEDGTNIQTPEQMAKYKQFAGCINCGLCYAACP
QFGLNPEFIGPAALALAHRYNLDSRDNGKAERMKLINGDNGAWGCTFVGYCSDVCPKKVDPAAAVNQGKVESSMDFVISM
FKPDGSQVKTAEEA
>Mature_253_residues
SANRIQKIEILRYDPEHDAEPHFQTFEVPFDETMSVLDAIGYIKDNLDKDLSYRWSCRMAICGSCGIMVDGVPKLACKSF
LRDYPNGFKIEPLANFPIEKDLIVDMTPFIERLEAIKPYIIGNDRKPEDGTNIQTPEQMAKYKQFAGCINCGLCYAACPQ
FGLNPEFIGPAALALAHRYNLDSRDNGKAERMKLINGDNGAWGCTFVGYCSDVCPKKVDPAAAVNQGKVESSMDFVISMF
KPDGSQVKTAEEA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=34.3347639484979, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1790596, Length=243, Percent_Identity=73.2510288065844, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1786943, Length=228, Percent_Identity=36.8421052631579, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17533915, Length=236, Percent_Identity=35.1694915254237, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322987, Length=237, Percent_Identity=34.1772151898734, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=34.8936170212766, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24643156, Length=251, Percent_Identity=31.8725099601594, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28276; Mature: 28144

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANRIQKIEILRYDPEHDAEPHFQTFEVPFDETMSVLDAIGYIKDNLDKDLSYRWSCRM
CCCCCCEEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGIMVDGVPKLACKSFLRDYPNGFKIEPLANFPIEKDLIVDMTPFIERLEAIKPY
EEECCCCEEECCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECHHHHHHHHHHHCCE
IIGNDRKPEDGTNIQTPEQMAKYKQFAGCINCGLCYAACPQFGLNPEFIGPAALALAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
NLDSRDNGKAERMKLINGDNGAWGCTFVGYCSDVCPKKVDPAAAVNQGKVESSMDFVISM
CCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHEE
FKPDGSQVKTAEEA
ECCCCCCCCCCCCC
>Mature Secondary Structure 
SANRIQKIEILRYDPEHDAEPHFQTFEVPFDETMSVLDAIGYIKDNLDKDLSYRWSCRM
CCCCCEEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGIMVDGVPKLACKSFLRDYPNGFKIEPLANFPIEKDLIVDMTPFIERLEAIKPY
EEECCCCEEECCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECHHHHHHHHHHHCCE
IIGNDRKPEDGTNIQTPEQMAKYKQFAGCINCGLCYAACPQFGLNPEFIGPAALALAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
NLDSRDNGKAERMKLINGDNGAWGCTFVGYCSDVCPKKVDPAAAVNQGKVESSMDFVISM
CCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHEE
FKPDGSQVKTAEEA
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]