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The map label for this gene is creC [H]

Identifier: 218551703

GI number: 218551703

Start: 4583614

End: 4585038

Strand: Direct

Name: creC [H]

Synonym: EFER_4498

Alternate gene names: 218551703

Gene position: 4583614-4585038 (Clockwise)

Preceding gene: 218551702

Following gene: 218551704

Centisome position: 99.89

GC content: 49.89

Gene sequence:

>1425_bases
ATGCGCATTGGAATGCGATTGCTGCTTGGCTACTTTCTCATTGTTGCCGTTGCCGCGTGGTTTGTGTTGTCGATTTTCGT
TCAGGAAATAAAACCTGGCGTGCGGCGGGCTACCGAAGGAACACTGATAGATACCGCCACACTTCTGGCAGCACTTGCGA
AAGAGGATATTCTTTCCGGTGATCCGGCACATGGGCAGCTGGCACAGGCTTTTACCCAACTGCAGGATCGTCCGTTTCGC
GCCAGTATTGATGGTATCAACAAGGTACGTAATGAGTACCATGTTTATATGACCGATGCACAAGGTCGTGTGTTATTTGA
TTCTGCCCGTAAAGCGCAAGGTGAGGATTATTCCCGCTGGAATGATGTCTGGCTGACGTTGCGAGGGCAATACGGCGCGC
GTAGCACCCTGCAAAATCCTGCTAATCCCGAAAGTTCAGTGATGTATGTCGCCGCACCTGTTATGGATGGTACGCGGCTC
ATTGGTGTACTGAGTGTAGGCAAGCCAAACGCGGCAATGGCGCCTGTCATTAAGCGCAGCGAGCGCCGCATCCTCTGGGC
GAGTGCACTATTACTGGGGATTGCGCTGGTGATAGGGGGCGCGATGATCTGGTGGATAAATCGCTCAATTGCCCGGCTGA
CAAATTATGCTGACTCTATTACTGAAAATAATCCCGTGCCTTTACCGGAATTAGGCAGTAGTGAATTGCGAAAACTGGCA
CAGGCACTGGAAAGCATGCGCGTGAAGCTGGAGGGGAAAAACTATATTGAACAATATGTTTATGCATTAACACATGAGCT
AAAAAGTCCGCTGGCAGCCATTCGTGGCGCGGCAGAAATTTTGCGTGAAGGGCCACCACCAGAAATAGTGACTCGCTTTA
CAGAAAACATTCTGACGCAAAATGCCAGAATGCAGACGTTGGTGGAGACCTTACTGCGTCAGGCACGGCTGGAAAATCGG
CAGGAGGTGACTTTTTCCCCGGTCAATGTCGATGCTCTGTTTAAGCAAGTTACTGAGGCGCGTGCGGTGCAACTGGCGGC
GAAGAAAATCACTTTAGAAATACTTCCATCTGATTATTGGGTGTTAGCAGACCCCGCTTTGCTGGAGCAGGCAACGGGGA
ATTTGCTGGATAATGCTATCGATTTTACGCCAGAAAACGGCACTATCATTCTTAGCGCTTTCGCCCAGGAAAATAGTGTG
ACATTGAATATACAAGATACGGGGTACGGCATTCCTGACTACGCATTGCCCCGTATTTTCGAGCGTTTCTACTCATTACC
GCGTGAAAATGGCCTGAAAAGTAGTGGGTTGGGGCTGGCATTTGTCAGAGAGGTTGCCCGCTTACTGAAAGGTGATGTCA
CTCTGCAAAATGTGGCTGAAGGTGGCGTACTGGCTTCGTTATCACTTCACCGTTACTTCACATAA

Upstream 100 bases:

>100_bases
CCCATATTAAAACGCTACGCGCTAAGTTACGGGCAATTAACCCGGCACTTTCACCAATCAATACACATCGCGGAATGGGA
TACAGTCTGGGGAGCGCCTG

Downstream 100 bases:

>100_bases
CTTCAAATTCTCTGCACATAACCTTTTTATTCTGCAAGCCTTGCAAAGGAGAAGGTTATGTTGAGATCCCCATTGTTGTG
GAAAATTGTCACGTTAAGTG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLIVAVAAWFVLSIFVQEIKPGVRRATEGTLIDTATLLAALAKEDILSGDPAHGQLAQAFTQLQDRPFR
ASIDGINKVRNEYHVYMTDAQGRVLFDSARKAQGEDYSRWNDVWLTLRGQYGARSTLQNPANPESSVMYVAAPVMDGTRL
IGVLSVGKPNAAMAPVIKRSERRILWASALLLGIALVIGGAMIWWINRSIARLTNYADSITENNPVPLPELGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEIVTRFTENILTQNARMQTLVETLLRQARLENR
QEVTFSPVNVDALFKQVTEARAVQLAAKKITLEILPSDYWVLADPALLEQATGNLLDNAIDFTPENGTIILSAFAQENSV
TLNIQDTGYGIPDYALPRIFERFYSLPRENGLKSSGLGLAFVREVARLLKGDVTLQNVAEGGVLASLSLHRYFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLIVAVAAWFVLSIFVQEIKPGVRRATEGTLIDTATLLAALAKEDILSGDPAHGQLAQAFTQLQDRPFR
ASIDGINKVRNEYHVYMTDAQGRVLFDSARKAQGEDYSRWNDVWLTLRGQYGARSTLQNPANPESSVMYVAAPVMDGTRL
IGVLSVGKPNAAMAPVIKRSERRILWASALLLGIALVIGGAMIWWINRSIARLTNYADSITENNPVPLPELGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEIVTRFTENILTQNARMQTLVETLLRQARLENR
QEVTFSPVNVDALFKQVTEARAVQLAAKKITLEILPSDYWVLADPALLEQATGNLLDNAIDFTPENGTIILSAFAQENSV
TLNIQDTGYGIPDYALPRIFERFYSLPRENGLKSSGLGLAFVREVARLLKGDVTLQNVAEGGVLASLSLHRYFT
>Mature_474_residues
MRIGMRLLLGYFLIVAVAAWFVLSIFVQEIKPGVRRATEGTLIDTATLLAALAKEDILSGDPAHGQLAQAFTQLQDRPFR
ASIDGINKVRNEYHVYMTDAQGRVLFDSARKAQGEDYSRWNDVWLTLRGQYGARSTLQNPANPESSVMYVAAPVMDGTRL
IGVLSVGKPNAAMAPVIKRSERRILWASALLLGIALVIGGAMIWWINRSIARLTNYADSITENNPVPLPELGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEIVTRFTENILTQNARMQTLVETLLRQARLENR
QEVTFSPVNVDALFKQVTEARAVQLAAKKITLEILPSDYWVLADPALLEQATGNLLDNAIDFTPENGTIILSAFAQENSV
TLNIQDTGYGIPDYALPRIFERFYSLPRENGLKSSGLGLAFVREVARLLKGDVTLQNVAEGGVLASLSLHRYFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=83.5443037974684, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=30.4498269896194, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=219, Percent_Identity=23.7442922374429, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=26.7241379310345, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=25.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=25.7575757575758, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=26.7857142857143, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=287, Percent_Identity=28.9198606271777, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=23.9316239316239, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=24.7272727272727, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787894, Length=216, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788279, Length=265, Percent_Identity=24.5283018867925, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87081816, Length=217, Percent_Identity=24.8847926267281, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52436; Mature: 52436

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLIVAVAAWFVLSIFVQEIKPGVRRATEGTLIDTATLLAALAKEDILSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
DPAHGQLAQAFTQLQDRPFRASIDGINKVRNEYHVYMTDAQGRVLFDSARKAQGEDYSRW
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCEEECCHHHCCCCCCCCC
NDVWLTLRGQYGARSTLQNPANPESSVMYVAAPVMDGTRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHC
ERRILWASALLLGIALVIGGAMIWWINRSIARLTNYADSITENNPVPLPELGSSELRKLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEIVTRFTENILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
NARMQTLVETLLRQARLENRQEVTFSPVNVDALFKQVTEARAVQLAAKKITLEILPSDYW
CHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
VLADPALLEQATGNLLDNAIDFTPENGTIILSAFAQENSVTLNIQDTGYGIPDYALPRIF
EEECHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
ERFYSLPRENGLKSSGLGLAFVREVARLLKGDVTLQNVAEGGVLASLSLHRYFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHCCC
>Mature Secondary Structure
MRIGMRLLLGYFLIVAVAAWFVLSIFVQEIKPGVRRATEGTLIDTATLLAALAKEDILSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
DPAHGQLAQAFTQLQDRPFRASIDGINKVRNEYHVYMTDAQGRVLFDSARKAQGEDYSRW
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCEEECCHHHCCCCCCCCC
NDVWLTLRGQYGARSTLQNPANPESSVMYVAAPVMDGTRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHC
ERRILWASALLLGIALVIGGAMIWWINRSIARLTNYADSITENNPVPLPELGSSELRKLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEIVTRFTENILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
NARMQTLVETLLRQARLENRQEVTFSPVNVDALFKQVTEARAVQLAAKKITLEILPSDYW
CHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
VLADPALLEQATGNLLDNAIDFTPENGTIILSAFAQENSVTLNIQDTGYGIPDYALPRIF
EEECHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
ERFYSLPRENGLKSSGLGLAFVREVARLLKGDVTLQNVAEGGVLASLSLHRYFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]