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The map label for this gene is creB [H]

Identifier: 218551702

GI number: 218551702

Start: 4582925

End: 4583614

Strand: Direct

Name: creB [H]

Synonym: EFER_4497

Alternate gene names: 218551702

Gene position: 4582925-4583614 (Clockwise)

Preceding gene: 218551701

Following gene: 218551703

Centisome position: 99.87

GC content: 51.45

Gene sequence:

>690_bases
ATGCAACAAGTCCGGGTCTGGTTAGTGGAAGATGAGCAAGGGATCGCCGACACGTTGATCTACATGCTTACTCAAGAAGG
ATTTCTTGTTGAGGCTTTTGAGCGGGGATTGCCTGCTCTGGAAAAAGCGCATTTTCAAGTGCCGGATGTCGCTATTCTCG
ATGTTGGTTTGCCCGATATCAGTGGATTTGAGTTATGCCGTCAGCTGCTGGAGCGCCATCCGGCGCTGCCCATTCTTTTC
CTGACCGCCCGTAGTGATGAAGTGGATCGCCTGCTGGGGCTGGAAATCGGTGCCGATGATTATGTTGCAAAACCATTCTC
ACCCCGCGAAGTCTGCGCCAGAGTGCGAACGCTGCTGCGGCGGGTAAAGAAATTTTCTGCACCTTCGCCTGTTATCCGCT
GTGGTCAGTTTGAGCTGAACGAACCCGCTGCACAGATAAGCTGGTGTGATACTCCATTGCAGCTCACGCGCTATGAATTT
TTACTGTTAAAAACACTGATTATGTCGCCAGGCCGTGTCTGGTCACGCCAGCAGTTGATGGATAAAGTCTGGGCGGATGC
ACAGGATACTTTTGACCGAACGGTAGATACCCATATTAAAACGCTACGCGCTAAGTTACGGGCAATTAACCCGGCACTTT
CACCAATCAATACACATCGCGGAATGGGATACAGTCTGGGGAGCGCCTGA

Upstream 100 bases:

>100_bases
AGCTTATCTGGCCTACTCCGACAAAGTGGTCGATGGCTCACCAAAAAATGCGATTAGCGCAGTACCTGTGATGCCGTGGC
GGCAATAAGCGAGTAATGCG

Downstream 100 bases:

>100_bases
TGCGCATTGGAATGCGATTGCTGCTTGGCTACTTTCTCATTGTTGCCGTTGCCGCGTGGTTTGTGTTGTCGATTTTCGTT
CAGGAAATAAAACCTGGCGT

Product: DNA-binding response regulator CreB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MQQVRVWLVEDEQGIADTLIYMLTQEGFLVEAFERGLPALEKAHFQVPDVAILDVGLPDISGFELCRQLLERHPALPILF
LTARSDEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSAPSPVIRCGQFELNEPAAQISWCDTPLQLTRYEF
LLLKTLIMSPGRVWSRQQLMDKVWADAQDTFDRTVDTHIKTLRAKLRAINPALSPINTHRGMGYSLGSA

Sequences:

>Translated_229_residues
MQQVRVWLVEDEQGIADTLIYMLTQEGFLVEAFERGLPALEKAHFQVPDVAILDVGLPDISGFELCRQLLERHPALPILF
LTARSDEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSAPSPVIRCGQFELNEPAAQISWCDTPLQLTRYEF
LLLKTLIMSPGRVWSRQQLMDKVWADAQDTFDRTVDTHIKTLRAKLRAINPALSPINTHRGMGYSLGSA
>Mature_229_residues
MQQVRVWLVEDEQGIADTLIYMLTQEGFLVEAFERGLPALEKAHFQVPDVAILDVGLPDISGFELCRQLLERHPALPILF
LTARSDEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSAPSPVIRCGQFELNEPAAQISWCDTPLQLTRYEF
LLLKTLIMSPGRVWSRQQLMDKVWADAQDTFDRTVDTHIKTLRAKLRAINPALSPINTHRGMGYSLGSA

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=88.0530973451327, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=42.4778761061947, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=35.9649122807018, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=35.0649350649351, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=35.8078602620087, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=36.1990950226244, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=36.4864864864865, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=36.2445414847162, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=34.2222222222222, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.0649350649351, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=32.9004329004329, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=31.4159292035398, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=32.7354260089686, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790299, Length=146, Percent_Identity=32.8767123287671, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25929; Mature: 25929

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQVRVWLVEDEQGIADTLIYMLTQEGFLVEAFERGLPALEKAHFQVPDVAILDVGLPDI
CCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCCCEEEEECCCCCC
SGFELCRQLLERHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLR
CHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHH
RVKKFSAPSPVIRCGQFELNEPAAQISWCDTPLQLTRYEFLLLKTLIMSPGRVWSRQQLM
HHHHCCCCCCCEECCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
DKVWADAQDTFDRTVDTHIKTLRAKLRAINPALSPINTHRGMGYSLGSA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MQQVRVWLVEDEQGIADTLIYMLTQEGFLVEAFERGLPALEKAHFQVPDVAILDVGLPDI
CCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCCCEEEEECCCCCC
SGFELCRQLLERHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLR
CHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHH
RVKKFSAPSPVIRCGQFELNEPAAQISWCDTPLQLTRYEFLLLKTLIMSPGRVWSRQQLM
HHHHCCCCCCCEECCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
DKVWADAQDTFDRTVDTHIKTLRAKLRAINPALSPINTHRGMGYSLGSA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503 [H]