Click here to switch to the map view.

The map label for this gene is cpxA [H]

Identifier: 218551105

GI number: 218551105

Start: 3954710

End: 3956083

Strand: Direct

Name: cpxA [H]

Synonym: EFER_3861

Alternate gene names: 218551105

Gene position: 3954710-3956083 (Clockwise)

Preceding gene: 218551104

Following gene: 218551108

Centisome position: 86.18

GC content: 54.59

Gene sequence:

>1374_bases
ATGATAGGCAGCTTAACCGCGCGCATCTTCGCCATCTTCTGGCTGACGCTGGCGCTGGTGTTGATGTTGGTTTTGATGTT
ACCCAAGCTCGATTCACGCCAGATGACCGAGCTTCTGGATAGCGAACAGCGTCAGGGGCTGATGATTGAGCAGCATGTCG
AAGCAGAACTGGCGAACGATCCACCGAACGATTTAATGTGGTGGCGGCGTCTCTTCCGGGCCATTGATAAGTGGGCACCG
CCAGGCCAGCGTTTGTTACTGGTAACTACGGAAGGCCGCGTGATCGGCGCTGAACGCAGCGAAATGCAGATCATTCGCAA
CTTTATTGGCCAGGCCGATAACGCTGATCACCCGCAAAAGAAAAAGTATGGCCGCGTGGAACTGGTCGGTCCGTTCTCCG
TGCGTGATGGCGAAGATAATTACCAACTGTATCTGATTCGTCCGGCCAGCAGTTCTCAATCCGATTTCATTAACTTACTG
TTTGACCGCCCGCTATTACTGCTGATTGTGACTATGTTGGTCAGTACACCGTTGCTGTTGTGGTTGGCCTGGAGTCTGGC
AAAACCGGCGCGTAAGCTGAAAAACGCTGCCGATGAAGTTGCCCAGGGGAACTTACGCCAGCACCCGGAACTGGAAGCGG
GGCCACAGGAATTCCTTGCCGCAGGTGCCAGTTTTAACCAGATGGTCACCGCGCTGGAGCGCATGATGACCTCTCAGCAG
CGTCTGCTTTCTGATATCTCTCACGAGCTACGCACCCCGCTGACGCGTCTGCAACTGGGTACGGCGTTACTGCGCCGTCG
TAGTGGTGAAAGCAAGGAACTGGAGCGTATTGAAACCGAAGCCCAGCGTCTGGACAGCATGATCAACGACCTGTTGGTGA
TGTCACGTAATCAGCAGAAAAACGCGCTGGTGAGCGAGACATTGAAAGCTAACCAGTTGTGGGGTGAAGTGCTGGATAAC
GCGGCGTTCGAAGCGGAACAAATGGGCAAGTCGTTGACGGTTAACTTCCCGCCTGGGCCGTGGCCTCTGTATGGCAACCC
GAACGCTCTGGAAAGTGCGCTGGAAAACATTGTTCGTAATGCTCTGCGTTATTCCCATACGAAGATTGAAGTGGGCTTTG
CGGTAGATAAAGATGGCATCACCATTACGGTGGACGACGATGGTCCTGGCGTTAGCCCGGAAGATCGCGAGCAGATTTTC
CGTCCGTTCTATCGCACCGATGAAGCGCGCGATCGTGAATCTGGCGGCACGGGCTTAGGGCTGGCGATTGTTGAAACCGC
CATCCAGCAGCATCGTGGTTGGGTAAAAGCGGAAGACAGCCCGCTCGGCGGTTTACGGCTGGTGATTTGGTTGCCGCTGT
ATAAGCGTAGTTAA

Upstream 100 bases:

>100_bases
TGCATATCTCTAACCTGCGTCGTAAGCTGCCGGATCGTAAAGACGGTCACCCGTGGTTTAAAACCTTGCGTGGTCGCGGC
TATCTGATGGTTTCTGCTTC

Downstream 100 bases:

>100_bases
CCGCGCAGGGCAGCTTTTGTAGCCGGATAAGGCGTTTACGCCGCATCCGGCATCATGTCTTATTTTCCCCACAACCGCCG
TGAATTATCTTCAATCTTGC

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL
FDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETLKANQLWGEVLDN
AAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS

Sequences:

>Translated_457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL
FDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETLKANQLWGEVLDN
AAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS
>Mature_457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL
FDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETLKANQLWGEVLDN
AAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=457, Percent_Identity=99.562363238512, Blast_Score=922, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=32.6666666666667, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789808, Length=267, Percent_Identity=31.4606741573034, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786783, Length=332, Percent_Identity=30.1204819277108, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=28.0575539568345, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=30.3030303030303, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=26.6932270916335, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788279, Length=276, Percent_Identity=24.2753623188406, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786912, Length=274, Percent_Identity=31.021897810219, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=23.9057239057239, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=217, Percent_Identity=29.4930875576037, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=27.6666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=25.5707762557078, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789403, Length=237, Percent_Identity=28.6919831223629, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=287, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=27.8008298755187, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=206, Percent_Identity=27.6699029126214, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=26.4, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51595; Mature: 51595

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQK
CCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCHHHHHHHHHHHCCCCCCCCCHH
KKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLL
HHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQK
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NALVSETLKANQLWGEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCHH
LAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS
HHHHHHHHHHHCCCEECCCCCCCCEEEEEEECHHCCC
>Mature Secondary Structure
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQK
CCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCHHHHHHHHHHHCCCCCCCCCHH
KKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLL
HHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQK
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NALVSETLKANQLWGEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCHH
LAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS
HHHHHHHHHHHCCCEECCCCCCCCEEEEEEECHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]