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The map label for this gene is cpxR [H]

Identifier: 218551104

GI number: 218551104

Start: 3954015

End: 3954713

Strand: Direct

Name: cpxR [H]

Synonym: EFER_3860

Alternate gene names: 218551104

Gene position: 3954015-3954713 (Clockwise)

Preceding gene: 218551098

Following gene: 218551105

Centisome position: 86.17

GC content: 51.79

Gene sequence:

>699_bases
ATGAATAAAATTCTGTTAGTTGATGATGACCGAGAGCTGACTTCCCTGTTAAAGGAACTGCTCGAAATGGAAGGCTTCAA
TGTGGTTGTTGCCCATGACGGGGAACAAGCACTCGAACTTCTGGACGACAGCATTGATTTACTTTTGCTTGACGTGATGA
TGCCGAAGAAAAATGGCATTGATACCCTTAAAGCACTTCGCCAGACACACCAGACTCCCGTCATTATGCTGACCGCTCGT
GGCAGCGAACTTGATCGCGTCCTCGGCCTTGAGCTGGGCGCAGATGACTATCTCCCGAAACCGTTCAATGATCGTGAACT
GGTTGCGCGGATCCGCGCGATCCTGCGTCGTTCGCACTGGAGCGAACAACAACAAAACAATGACAATAGTTCCCCAACCC
TGGAAGTAGACGCCTTAAGTCTCAACCCTGGTCGCCAGGAGGCCAGCTTCGACGGGCAAACGCTGGAGTTGACTGGCACT
GAATTTACCCTGCTCTACTTACTGGCACAGCATCTGGGTCAGGTGGTTTCCCGTGAACATTTAAGCCAGGAAGTGCTGGG
CAAGCGCCTGACGCCTTTCGACCGCGCTATCGATATGCATATCTCTAACCTGCGTCGTAAGCTGCCGGATCGTAAAGACG
GTCACCCGTGGTTTAAAACCTTGCGTGGTCGCGGCTATCTGATGGTTTCTGCTTCATGA

Upstream 100 bases:

>100_bases
GATTCAGGCTGCAAACATGCGTCAGGGGGTGTAAAACAACGTAAAGTCATGGATTAGCGTCGTCTGATGACGTAATTTCT
GCCTCGGAGGTACTTAAACA

Downstream 100 bases:

>100_bases
TAGGCAGCTTAACCGCGCGCATCTTCGCCATCTTCTGGCTGACGCTGGCGCTGGTGTTGATGTTGGTTTTGATGTTACCC
AAGCTCGATTCACGCCAGAT

Product: DNA-binding transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNKILLVDDDRELTSLLKELLEMEGFNVVVAHDGEQALELLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNSSPTLEVDALSLNPGRQEASFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS

Sequences:

>Translated_232_residues
MNKILLVDDDRELTSLLKELLEMEGFNVVVAHDGEQALELLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNSSPTLEVDALSLNPGRQEASFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
>Mature_232_residues
MNKILLVDDDRELTSLLKELLEMEGFNVVVAHDGEQALELLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNSSPTLEVDALSLNPGRQEASFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=98.2758620689655, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=40.4255319148936, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=38.2222222222222, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=40.174672489083, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=234, Percent_Identity=36.7521367521368, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=32.4444444444444, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.6106194690265, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=37.9310344827586, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.6017316017316, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=35.5263157894737, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=36.2068965517241, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=33.7606837606838, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.8947368421053, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=29.5652173913043, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790299, Length=139, Percent_Identity=39.568345323741, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=39.0909090909091, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=39.8305084745763, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=38.3928571428571, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26331; Mature: 26331

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILLVDDDRELTSLLKELLEMEGFNVVVAHDGEQALELLDDSIDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCHHHHHHHHHCCCCCCH
DTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
SEQQQNNDNSSPTLEVDALSLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
HHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MNKILLVDDDRELTSLLKELLEMEGFNVVVAHDGEQALELLDDSIDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCHHHHHHHHHCCCCCCH
DTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
SEQQQNNDNSSPTLEVDALSLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
HHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]