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The map label for this gene is aaeB [H]

Identifier: 218550524

GI number: 218550524

Start: 3301664

End: 3303631

Strand: Reverse

Name: aaeB [H]

Synonym: EFER_3218

Alternate gene names: 218550524

Gene position: 3303631-3301664 (Counterclockwise)

Preceding gene: 218550525

Following gene: 218550523

Centisome position: 71.99

GC content: 50.66

Gene sequence:

>1968_bases
ATGGGCATTTTTTCTATAGCTAACCAACATATTCGCTTTGCAGTCAAGCTGGCGAGCGCCATCGTGTTGACGCTGTTTGT
CGGTTTCCATTTTCAGCTGGAGACGCCACGCTGGGCGGTATTGACGGCGGCAATTGTCGCCGCTGGCCCGGCGTTTGCCG
CCGGGGGAGAGCCTTACGCCGGGGCGATTCGTTATCGCGGAATGTTGCGTATTATTGGGACGTTTATTGGTTGTATCGCC
GGGTTGGTGATTATCATCGCTATGATCCGTGCGCCACTGTTGATGATTCTGGTGTGCTGTATCTGGGCTGGATTTTGTAC
CTGGATCTCATCGCTGGTACGGGTTGAAAATTCGTATGCGTGGGGGCTGGCAGGCTACACCGCGCTCATTATCGTCATTA
CCATTCAGCCCGAGCCTTTGCTGACGCCGCAGTTTGCGCTTGAACGTTGCAGTGAGATTGTCGTCGGTATTGTCTGCGCA
ATTGTGGCGGACCTGATCTTTTCGCCGCGATCGATCAAACAAGAAGTGGATCGTGAACTGGATAGCTTGCTGGTGGCCCA
GTATCAACTGATGCAGTTGTGTATCAAACACGGTGAAGCGGAGGAGGTGGACAAAGCCTGGGGAAATCTGGTGCGGCGGA
CAACAGCCCTGGAAGGGATGCGCAGCAATCTTAATATGGAATCTTCCCGCTGGGCGCGGGCAAATCGACGCTTAAAAGCA
CTTAATACGTTATCGCTGACATTGATTACTCAATCATGCGAAACCTATTTAATTCAGAACACCCGACCAGAACTGATCAC
CGAGACTTTTCGGGAGTTCTTCAGCACTCCTGTTGAAACTGCTCAGGATGTGCATAAGCAGCTTAAGCGTTTACGTCGCG
TTATTGCATGGACAGGAGAGCGTGAAACGCCCGTGACGATTTATAGTTGGGCAGGGGCGGCGACACGTTATCTGTTGATC
AAACGCGGGGTTATCAGCAACACCAAAATTAGCGCTACGGAAGAAGAGATCTTACAAGGTGAGCCGGTGGTGAAAGCCGA
GTCAGCCGAACGCCACCACGCAATGGTTAACTTCTGGCGAACCACGATTTCTTGCGTGTTGGGAACATTGTTCTGGTTAT
GGACCGGCTGGACTTCTGGTAGTGGGGCAATGGTGATGATTGCTGTTGTAACATCACTGGCAATGCGGCTGCCTAATCCT
CGAATGGTGGGAATCGATTTTATCTATGGCACGCTGGCGGCACTGCCGTTGGGGTTACTCTATTTTTTGGTGATCATCCC
CAATACGCAACAAAGCATGTTGTTGTTATGCCTGAGTCTGGCAGTGCTGGGATTCTTCCTTGGTATTGAAGTGCAAAAAC
GTCGACTGGGTTCGATGGGGGCGCTGGCCAGTACAATTAACATCATTGTGCTGGATAACCCGATGAAGTTTGAATTCAGT
TTGTTCCTGGATAGCGCGCTTGGACAGATTGTCGGCTGCGTGTTGGCATTTACCGTCATTTTGCTGGTGCGTGATAAATC
CCGGGATCGCACCGGACGTGTGTTGCTAAATCAGTTTGTCTCAGCGGCTATCTCTGCCATGACGACTAATGTCGTGCGAC
GTAAAGAGAATCACCTTCCGGCACTTTATCAGCAGCTGTTCTTGTTAATGAATAAGTTTCCTGGTGATCTGCCGAAGTTT
CGTCTGGCATTGACGATGATTATTGCTCATCAGCGTTTGCGCGATGCACCCGTACCGATTAACGACGACTTATCTGCATT
TCATCGTCAGATGCGGCGCACTGCCGATAAGGTGATTTCTGCACGCAGCGATGATAAACGACGTAAATATTTTAGCCAGC
TGCTGGAAGAGCTGGAGATTTATCAGGAGAAATTGCGGATATGGCACGCACCGCCACAAGTCACCGAGCCGGTGAAGCGA
CTTTCAGGCATGTTGCATAAGTATCAACATGCGCTGACAAGCAGTTAA

Upstream 100 bases:

>100_bases
CAGCAACGGTGGTGGTTACCGGGAAAGATGATCGTGACGAGAGTCAGGATTCATTCTTTCGCAAAATGGCTCACCGACTG
CGTGAGTTTGGTTAATCACG

Downstream 100 bases:

>100_bases
GTATGAAAACCGATGCCAACAGCGTCGGTTTTTTTACGCCTATACTTAGTCGTTGTGCGGATAATCTGATCACTATGTCA
TGTGGAAAGCCGACGGAAAA

Product: p-hydroxybenzoic acid efflux subunit AaeB

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MGIFSIANQHIRFAVKLASAIVLTLFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYAGAIRYRGMLRIIGTFIGCIA
GLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRVENSYAWGLAGYTALIIVITIQPEPLLTPQFALERCSEIVVGIVCA
IVADLIFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGEAEEVDKAWGNLVRRTTALEGMRSNLNMESSRWARANRRLKA
LNTLSLTLITQSCETYLIQNTRPELITETFREFFSTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWAGAATRYLLI
KRGVISNTKISATEEEILQGEPVVKAESAERHHAMVNFWRTTISCVLGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNP
RMVGIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMKFEFS
LFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAISAMTTNVVRRKENHLPALYQQLFLLMNKFPGDLPKF
RLALTMIIAHQRLRDAPVPINDDLSAFHRQMRRTADKVISARSDDKRRKYFSQLLEELEIYQEKLRIWHAPPQVTEPVKR
LSGMLHKYQHALTSS

Sequences:

>Translated_655_residues
MGIFSIANQHIRFAVKLASAIVLTLFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYAGAIRYRGMLRIIGTFIGCIA
GLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRVENSYAWGLAGYTALIIVITIQPEPLLTPQFALERCSEIVVGIVCA
IVADLIFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGEAEEVDKAWGNLVRRTTALEGMRSNLNMESSRWARANRRLKA
LNTLSLTLITQSCETYLIQNTRPELITETFREFFSTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWAGAATRYLLI
KRGVISNTKISATEEEILQGEPVVKAESAERHHAMVNFWRTTISCVLGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNP
RMVGIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMKFEFS
LFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAISAMTTNVVRRKENHLPALYQQLFLLMNKFPGDLPKF
RLALTMIIAHQRLRDAPVPINDDLSAFHRQMRRTADKVISARSDDKRRKYFSQLLEELEIYQEKLRIWHAPPQVTEPVKR
LSGMLHKYQHALTSS
>Mature_654_residues
GIFSIANQHIRFAVKLASAIVLTLFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYAGAIRYRGMLRIIGTFIGCIAG
LVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRVENSYAWGLAGYTALIIVITIQPEPLLTPQFALERCSEIVVGIVCAI
VADLIFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGEAEEVDKAWGNLVRRTTALEGMRSNLNMESSRWARANRRLKAL
NTLSLTLITQSCETYLIQNTRPELITETFREFFSTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWAGAATRYLLIK
RGVISNTKISATEEEILQGEPVVKAESAERHHAMVNFWRTTISCVLGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPR
MVGIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMKFEFSL
FLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAISAMTTNVVRRKENHLPALYQQLFLLMNKFPGDLPKFR
LALTMIIAHQRLRDAPVPINDDLSAFHRQMRRTADKVISARSDDKRRKYFSQLLEELEIYQEKLRIWHAPPQVTEPVKRL
SGMLHKYQHALTSS

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=655, Percent_Identity=93.1297709923664, Blast_Score=1248, Evalue=0.0,
Organism=Escherichia coli, GI1787933, Length=517, Percent_Identity=23.4042553191489, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 73423; Mature: 73291

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIFSIANQHIRFAVKLASAIVLTLFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHCCCCCCCCCCCCH
GAIRYRGMLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRVENSYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGLAGYTALIIVITIQPEPLLTPQFALERCSEIVVGIVCAIVADLIFSPRSIKQEVDREL
CHHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DSLLVAQYQLMQLCIKHGEAEEVDKAWGNLVRRTTALEGMRSNLNMESSRWARANRRLKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LNTLSLTLITQSCETYLIQNTRPELITETFREFFSTPVETAQDVHKQLKRLRRVIAWTGE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
RETPVTIYSWAGAATRYLLIKRGVISNTKISATEEEILQGEPVVKAESAERHHAMVNFWR
CCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEECCCCHHHHHHHHHHH
TTISCVLGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVGIDFIYGTLAALPLGLL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
YFLVIIPNTQQSMLLLCLSLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMKFEFS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEEEECCCCCCHHH
LFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAISAMTTNVVRRKENHLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPVPINDDLSAFHRQMRRTADKVIS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
ARSDDKRRKYFSQLLEELEIYQEKLRIWHAPPQVTEPVKRLSGMLHKYQHALTSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIFSIANQHIRFAVKLASAIVLTLFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHCCCCCCCCCCCCH
GAIRYRGMLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRVENSYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGLAGYTALIIVITIQPEPLLTPQFALERCSEIVVGIVCAIVADLIFSPRSIKQEVDREL
CHHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DSLLVAQYQLMQLCIKHGEAEEVDKAWGNLVRRTTALEGMRSNLNMESSRWARANRRLKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LNTLSLTLITQSCETYLIQNTRPELITETFREFFSTPVETAQDVHKQLKRLRRVIAWTGE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
RETPVTIYSWAGAATRYLLIKRGVISNTKISATEEEILQGEPVVKAESAERHHAMVNFWR
CCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEECCCCHHHHHHHHHHH
TTISCVLGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVGIDFIYGTLAALPLGLL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
YFLVIIPNTQQSMLLLCLSLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMKFEFS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEEEECCCCCCHHH
LFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAISAMTTNVVRRKENHLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPVPINDDLSAFHRQMRRTADKVIS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
ARSDDKRRKYFSQLLEELEIYQEKLRIWHAPPQVTEPVKRLSGMLHKYQHALTSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA