Click here to switch to the map view.

The map label for this gene is tdcB [H]

Identifier: 218550358

GI number: 218550358

Start: 3122468

End: 3123457

Strand: Reverse

Name: tdcB [H]

Synonym: EFER_3050

Alternate gene names: 218550358

Gene position: 3123457-3122468 (Counterclockwise)

Preceding gene: 218550363

Following gene: 218550357

Centisome position: 68.07

GC content: 43.23

Gene sequence:

>990_bases
ATGCATATAACATATGATCTTCCGGTGACGATTAAAGACATTATTGAGGCAAAGCACCGTCTGGCAGGGCGAGTTTATAA
AACCGGGATGCCTCGCTCTAACTATTTTAGTGAATGTTGCAAGGGAGATATTTTTCTTAAGTTTGAAAATATGCAACGCA
CAGGGTCGTTTAAAATTCGTGGCGCATTCAATAAACTTTGTTCGCTCACGGATGCAGAAAAAAGTAAAGGCGTTGTCGCC
TGCTCTGCCGGGAATCATGCACAGGGCGTCTCTCTCTCATGTGCAATGTTAGGTATTGATAGCAAAGTCGTGATGCCAAA
AGCAGCACCAAAGTCAAAGGTGGCAGCTACCAGGGATTATTCTGCACAGGTTATCCTGCATGGCGATAACTTCAATGAAA
CCATTGCCAAAGTTAGTGAAATTGTTGAAATGGAGGGCCGTATATTTATTCCTCCTTATGATGATCCGAAAGTGATTGCA
GGTCAGGGAACAATTGGTCTGGAGATTTTAGAAGATCTCTATGATGTAGATAATATTATTGTACCTATCGGTGGTGGTGG
GTTAATTTCCGGCATCGCCCTTGCGATTAAATCAATTAACCCGACGATTAAAGTCATTGGCGTGCAAGCTCAAAATGTTC
ACGGCATGGCGGCGTCATTTTTTGCCGGAAATATAACCACTCACCGAACAGGCAGCACCCTGGCGGACGGTTGTGATGTT
TCTCGCCCAGGTCAAATAACCTATGAAATTGTTCGCCAACTTGTCGATAATATTGTCCTGGTGAGTGAGGATGAGATCCG
TAACAGTATTATTGCCTTAATTCAGCGTAATAAAGTTGTCACCGAAGGTGCTGGAGCATTAGCCTGTGCGGCATTATTAA
GCGGTAAACTCGATAGTGATATCCAGAACAGAAAAACCGTCAGCATCATTTCTGGTGGCAATATCGATCTTTCCCGCATT
TCTCAAATAATCGATTTTGTTGACGCTTAA

Upstream 100 bases:

>100_bases
AAGATAATTTGTGAGTTGGCGCACATAACACAATTTTCTTATTTTTTACAATTCTCAGCATTATTGATGTCATGAATTCG
GTAGTGTGAGTCTATTTTAA

Downstream 100 bases:

>100_bases
TTTTTTTGTAAGGATCAGGATATGAGTTCGACTGATAACATAGTCTCTGGCAAGGCACAACATTCTTACTGGCGTAAGTC
AGATACTACCTGGACACTGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MHITYDLPVTIKDIIEAKHRLAGRVYKTGMPRSNYFSECCKGDIFLKFENMQRTGSFKIRGAFNKLCSLTDAEKSKGVVA
CSAGNHAQGVSLSCAMLGIDSKVVMPKAAPKSKVAATRDYSAQVILHGDNFNETIAKVSEIVEMEGRIFIPPYDDPKVIA
GQGTIGLEILEDLYDVDNIIVPIGGGGLISGIALAIKSINPTIKVIGVQAQNVHGMAASFFAGNITTHRTGSTLADGCDV
SRPGQITYEIVRQLVDNIVLVSEDEIRNSIIALIQRNKVVTEGAGALACAALLSGKLDSDIQNRKTVSIISGGNIDLSRI
SQIIDFVDA

Sequences:

>Translated_329_residues
MHITYDLPVTIKDIIEAKHRLAGRVYKTGMPRSNYFSECCKGDIFLKFENMQRTGSFKIRGAFNKLCSLTDAEKSKGVVA
CSAGNHAQGVSLSCAMLGIDSKVVMPKAAPKSKVAATRDYSAQVILHGDNFNETIAKVSEIVEMEGRIFIPPYDDPKVIA
GQGTIGLEILEDLYDVDNIIVPIGGGGLISGIALAIKSINPTIKVIGVQAQNVHGMAASFFAGNITTHRTGSTLADGCDV
SRPGQITYEIVRQLVDNIVLVSEDEIRNSIIALIQRNKVVTEGAGALACAALLSGKLDSDIQNRKTVSIISGGNIDLSRI
SQIIDFVDA
>Mature_329_residues
MHITYDLPVTIKDIIEAKHRLAGRVYKTGMPRSNYFSECCKGDIFLKFENMQRTGSFKIRGAFNKLCSLTDAEKSKGVVA
CSAGNHAQGVSLSCAMLGIDSKVVMPKAAPKSKVAATRDYSAQVILHGDNFNETIAKVSEIVEMEGRIFIPPYDDPKVIA
GQGTIGLEILEDLYDVDNIIVPIGGGGLISGIALAIKSINPTIKVIGVQAQNVHGMAASFFAGNITTHRTGSTLADGCDV
SRPGQITYEIVRQLVDNIVLVSEDEIRNSIIALIQRNKVVTEGAGALACAALLSGKLDSDIQNRKTVSIISGGNIDLSRI
SQIIDFVDA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=36.1635220125786, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1789505, Length=329, Percent_Identity=89.0577507598784, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1790207, Length=275, Percent_Identity=39.6363636363636, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=317, Percent_Identity=39.7476340694006, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17537387, Length=313, Percent_Identity=39.297124600639, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508781, Length=317, Percent_Identity=29.9684542586751, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=39.5569620253165, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320930, Length=285, Percent_Identity=36.8421052631579, Blast_Score=175, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6319788, Length=281, Percent_Identity=27.4021352313167, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21355833, Length=317, Percent_Identity=38.1703470031546, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24645328, Length=221, Percent_Identity=38.4615384615385, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35210; Mature: 35210

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHITYDLPVTIKDIIEAKHRLAGRVYKTGMPRSNYFSECCKGDIFLKFENMQRTGSFKIR
CEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEE
GAFNKLCSLTDAEKSKGVVACSAGNHAQGVSLSCAMLGIDSKVVMPKAAPKSKVAATRDY
EHHHHHHCCCCCHHCCCEEEEECCCCCCCCEEEEEEEECCCEEECCCCCCCCCCEECCCC
SAQVILHGDNFNETIAKVSEIVEMEGRIFIPPYDDPKVIAGQGTIGLEILEDLYDVDNII
CEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCEE
VPIGGGGLISGIALAIKSINPTIKVIGVQAQNVHGMAASFFAGNITTHRTGSTLADGCDV
EEECCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCCEECCCCCCHHCCCCC
SRPGQITYEIVRQLVDNIVLVSEDEIRNSIIALIQRNKVVTEGAGALACAALLSGKLDSD
CCCCCHHHHHHHHHHHCEEEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCC
IQNRKTVSIISGGNIDLSRISQIIDFVDA
CCCCEEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHITYDLPVTIKDIIEAKHRLAGRVYKTGMPRSNYFSECCKGDIFLKFENMQRTGSFKIR
CEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEE
GAFNKLCSLTDAEKSKGVVACSAGNHAQGVSLSCAMLGIDSKVVMPKAAPKSKVAATRDY
EHHHHHHCCCCCHHCCCEEEEECCCCCCCCEEEEEEEECCCEEECCCCCCCCCCEECCCC
SAQVILHGDNFNETIAKVSEIVEMEGRIFIPPYDDPKVIAGQGTIGLEILEDLYDVDNII
CEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCEE
VPIGGGGLISGIALAIKSINPTIKVIGVQAQNVHGMAASFFAGNITTHRTGSTLADGCDV
EEECCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCCEECCCCCCHHCCCCC
SRPGQITYEIVRQLVDNIVLVSEDEIRNSIIALIQRNKVVTEGAGALACAALLSGKLDSD
CCCCCHHHHHHHHHHHCEEEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCC
IQNRKTVSIISGGNIDLSRISQIIDFVDA
CCCCEEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]