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The map label for this gene is tdcC

Identifier: 218550357

GI number: 218550357

Start: 3121115

End: 3122446

Strand: Reverse

Name: tdcC

Synonym: EFER_3049

Alternate gene names: 218550357

Gene position: 3122446-3121115 (Counterclockwise)

Preceding gene: 218550358

Following gene: 218550356

Centisome position: 68.05

GC content: 44.37

Gene sequence:

>1332_bases
ATGAGTTCGACTGATAACATAGTCTCTGGCAAGGCACAACATTCTTACTGGCGTAAGTCAGATACTACCTGGACACTGGG
ATTGTTCGGTACAGCTATTGGTGCTGGTGTGTTGTTCTTTCCTATTCGGGCAGGTTTTGGCGGCTTGATCCCTATTTTAG
TGATGTTGGTACTGGCGTATCCCATTGCTTTTTATTGCCATCGGGCGCTGGCGCGTTTGTGCCTCTCAGGTGCTAATCCT
TCCGGTAACATTACCGAAACGGTAGAAGAACACTTCGGAAAGACGGGGGGCGTGGTGATCACTTTCCTCTACTTTTTTGC
TATCTGCCCGCTGTTGTGGATTTATGGGGTCACGATTACCAATACGTTTATGACCTTCTGGGAAAACCAACTGCATCTGC
CCGCGCTTAACCGCGGTTTTGTCGCGCTGTTCTTATTGTTGCTAATGGCGGTCATCATCTGGTTTGGTAGGGATCTGATG
GTGAAGGTGATGAGTTTTCTGGTGTGGCCGTTTATTGCCTCTTTAGTGTTAATTTCTCTTTCATTGATTCCCTACTGGAA
CTCCGCCGTTATCGATCAGGTGGATCTCAGTGCACTGTCGCTTACTGGACATGACGGTATTCTGGTAACCGTATGGCTGG
GAATTTCTATTATGGTGTTCTCCTTTAACTTCTCGCCGATTGTCTCTTCTTTTGTCGTATTTAAACGTGAAGAGTATGAA
AAGAAGTTTGGACGCGACTTTACCGAACGTAAATGTTCCAAAATTATCTCCCGCGCCAGTATATTGATGGTCGCAGTAGT
GATGTTCTTCGCCTTTAGTTGCTTGTTTGCTCTTTCTCCACAAAATATGGCAGAGGCCAAAGCACAAAATATTCCTGTGC
TTTCTTATCTGGCAAATCACTTTTCTTCGATGTCAGGTTCGCAGTCAAGTTTTGCTCTGACGCTGGAATATGCCGCCTCT
ATTATTGCTCTGGTTGCTATTTTTAAATCCTTCTTTGGTCATTATCTCGGTACGCTGGAAGGGCTAAATAGGTTGATTAT
TAAGTTCGCGTATAAGGGCGACAAAAGTAAAATTTCGATGAGTAAATTGAATACCCTAAGTATGGTGTTCATTATGGGGT
CGACCTGGCTTGTAGCCTACGTTAATCCCAATATTCTGGATTTGATTGAAGCGATGGGAGCACCAATAATCGCTTCGCTA
CTTTGTCTTCTGCCGATGTATGCCATTCATAAAGTTCCGTCGCTGGCGAAATATCGGGGGAGAATAGATAACGTTTTTGT
TACCGCTATTGGTCTGCTGACGATTTCAAATATTGTCTACAAAGTGTTCTGA

Upstream 100 bases:

>100_bases
AAAAACCGTCAGCATCATTTCTGGTGGCAATATCGATCTTTCCCGCATTTCTCAAATAATCGATTTTGTTGACGCTTAAT
TTTTTTGTAAGGATCAGGAT

Downstream 100 bases:

>100_bases
ACGGTACTTACGTAAACAGGTTCTCTTTTTCATCCTCTGGGCGTGGTTAACTTCGCCCATTTTTTTTATTGTGATCTTCA
TCAAATGAAGAAATATTTTT

Product: threonine/serine transporter TdcC

Products: Proton [Cytoplasm]; D-serine [Cytoplasm]; L-threonine [Cytoplasm] [C]

Alternate protein names: H(+)/threonine-serine symporter

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSSTDNIVSGKAQHSYWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAYPIAFYCHRALARLCLSGANP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLHLPALNRGFVALFLLLLMAVIIWFGRDLM
VKVMSFLVWPFIASLVLISLSLIPYWNSAVIDQVDLSALSLTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVFKREEYE
KKFGRDFTERKCSKIISRASILMVAVVMFFAFSCLFALSPQNMAEAKAQNIPVLSYLANHFSSMSGSQSSFALTLEYAAS
IIALVAIFKSFFGHYLGTLEGLNRLIIKFAYKGDKSKISMSKLNTLSMVFIMGSTWLVAYVNPNILDLIEAMGAPIIASL
LCLLPMYAIHKVPSLAKYRGRIDNVFVTAIGLLTISNIVYKVF

Sequences:

>Translated_443_residues
MSSTDNIVSGKAQHSYWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAYPIAFYCHRALARLCLSGANP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLHLPALNRGFVALFLLLLMAVIIWFGRDLM
VKVMSFLVWPFIASLVLISLSLIPYWNSAVIDQVDLSALSLTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVFKREEYE
KKFGRDFTERKCSKIISRASILMVAVVMFFAFSCLFALSPQNMAEAKAQNIPVLSYLANHFSSMSGSQSSFALTLEYAAS
IIALVAIFKSFFGHYLGTLEGLNRLIIKFAYKGDKSKISMSKLNTLSMVFIMGSTWLVAYVNPNILDLIEAMGAPIIASL
LCLLPMYAIHKVPSLAKYRGRIDNVFVTAIGLLTISNIVYKVF
>Mature_442_residues
SSTDNIVSGKAQHSYWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAYPIAFYCHRALARLCLSGANPS
GNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLHLPALNRGFVALFLLLLMAVIIWFGRDLMV
KVMSFLVWPFIASLVLISLSLIPYWNSAVIDQVDLSALSLTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVFKREEYEK
KFGRDFTERKCSKIISRASILMVAVVMFFAFSCLFALSPQNMAEAKAQNIPVLSYLANHFSSMSGSQSSFALTLEYAASI
IALVAIFKSFFGHYLGTLEGLNRLIIKFAYKGDKSKISMSKLNTLSMVFIMGSTWLVAYVNPNILDLIEAMGAPIIASLL
CLLPMYAIHKVPSLAKYRGRIDNVFVTAIGLLTISNIVYKVF

Specific function: Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system)

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily

Homologues:

Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=88.0361173814898, Blast_Score=786, Evalue=0.0,
Organism=Escherichia coli, GI1789160, Length=442, Percent_Identity=50.4524886877828, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789211, Length=421, Percent_Identity=32.3040380047506, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI145693183, Length=427, Percent_Identity=25.2927400468384, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789961, Length=422, Percent_Identity=24.6445497630332, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDCC_ESCF3 (B7LQI2)

Other databases:

- EMBL:   CU928158
- RefSeq:   YP_002384148.1
- EnsemblBacteria:   EBESCT00000122672
- GeneID:   7119878
- GenomeReviews:   CU928158_GR
- KEGG:   efe:EFER_3049
- GeneTree:   EBGT00050000008986
- HOGENOM:   HBG296888
- ProtClustDB:   PRK13629
- BioCyc:   EFER585054:EFER_3049-MONOMER
- HAMAP:   MF_01583
- InterPro:   IPR004694
- InterPro:   IPR018227
- TIGRFAMs:   TIGR00814

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 49112; Mature: 48981

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2b99bbac)-; HASH(0x2b7ce4b4)-; HASH(0x2bbf0c08)-; HASH(0x2b7ee4c4)-; HASH(0x2b134e94)-; HASH(0x2b7ee56c)-; HASH(0x2b2d1880)-; HASH(0x28ea6708)-; HASH(0x2a8bce64)-; HASH(0x2bb57830)-; HASH(0x2b0c57e4)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTDNIVSGKAQHSYWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAY
CCCCCCCCCCCHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
PIAFYCHRALARLCLSGANPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTIT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTFMTFWENQLHLPALNRGFVALFLLLLMAVIIWFGRDLMVKVMSFLVWPFIASLVLISL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SLIPYWNSAVIDQVDLSALSLTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVFKREEYE
HHHCCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KKFGRDFTERKCSKIISRASILMVAVVMFFAFSCLFALSPQNMAEAKAQNIPVLSYLANH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
FSSMSGSQSSFALTLEYAASIIALVAIFKSFFGHYLGTLEGLNRLIIKFAYKGDKSKISM
HHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SKLNTLSMVFIMGSTWLVAYVNPNILDLIEAMGAPIIASLLCLLPMYAIHKVPSLAKYRG
HHHHHHHHHHEECCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHC
RIDNVFVTAIGLLTISNIVYKVF
CHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SSTDNIVSGKAQHSYWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAY
CCCCCCCCCCHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH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CHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm]; L-threonine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] Proton [Periplasm] + L-threonine [Periplasm] = Proton [Cytoplasm] + L-threonine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA