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The map label for this gene is mngR [H]

Identifier: 218549697

GI number: 218549697

Start: 2431924

End: 2432643

Strand: Direct

Name: mngR [H]

Synonym: EFER_2374

Alternate gene names: 218549697

Gene position: 2431924-2432643 (Clockwise)

Preceding gene: 218549682

Following gene: 218549698

Centisome position: 53.0

GC content: 45.97

Gene sequence:

>720_bases
ATGGGACGGAAACCCTTATACCGACAGATTGCTGATCGCATTCGTGAGCAGATTGCGCGTGGCGAGCTTAAACCTGGCGA
TGCGTTACCCACTGAATCAGCACTACAAACAGAGTTTGGCGTCAGCCGGGTTACGGTGCGTCAGGCTTTGCGACAATTAG
TCGAGCAGCAGATCCTTGAAAGTATTCAAGGCAGCGGGACTTACGTAAAAGAAGAGCGGGTCAATTACGATATTTTTCAG
TTAACCAGTTTCGATGAAAAAATGTCTGATCGACACATCGATACACACAGCGACGTCCTGGTGTTTGAAGTGATCCTGGC
TGATGATTTTCTCCAGCAGCAGCTGCAAATTAGCGAACAGGATCGCGTGTGGCATGTGAAGCGTGTGCGCTATCGCAAGC
AAAAGCCAATGGCACTGGAAGAAACCTGGATGCCGCTTTCATTGTTCCCGGATCTCACCTGGCAGGTCATGGAAAAATCG
AAATATCACTTTATTGAAGAAGTGAAGAAGATGGTTATTGATCGTAGTGAACAAGAGATAATCCCTCTGATGCCAACCGA
AGAGATGAGCCGTTTGCTTAATATCAGCCAGGATAAACCGATTCTCGAAAAAATATCGCGAGGATTCTTAATAGATGGGC
GGATATTTGAGTTCAGCCGAAATGCTTTTAATACAGATGACTATAAATTTACGCTTATCGCACGAAGAAGAGCCCACTGA

Upstream 100 bases:

>100_bases
AATTTCACTTGATTGAGATTATTTGTATTATATTTGTATTATTTACAGGATGAATTTATCGGGCATAATGACAAAATTCG
TATTAATGAGATGCTAAATA

Downstream 100 bases:

>100_bases
TATATGCGCTATATACTCTTAATATTGCAAGTTGCAGGACAAACGCCAGTAGCGTTTTGAACAATGCTTGCGTTGCCCCT
GAAATGAAGGGGCCGAATAA

Product: DNA-binding transcriptional repressor MngR

Products: NA

Alternate protein names: Fatty acyl-responsive regulator; Protein P30 [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MGRKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ
LTSFDEKMSDRHIDTHSDVLVFEVILADDFLQQQLQISEQDRVWHVKRVRYRKQKPMALEETWMPLSLFPDLTWQVMEKS
KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQDKPILEKISRGFLIDGRIFEFSRNAFNTDDYKFTLIARRRAH

Sequences:

>Translated_239_residues
MGRKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ
LTSFDEKMSDRHIDTHSDVLVFEVILADDFLQQQLQISEQDRVWHVKRVRYRKQKPMALEETWMPLSLFPDLTWQVMEKS
KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQDKPILEKISRGFLIDGRIFEFSRNAFNTDDYKFTLIARRRAH
>Mature_238_residues
GRKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL
TSFDEKMSDRHIDTHSDVLVFEVILADDFLQQQLQISEQDRVWHVKRVRYRKQKPMALEETWMPLSLFPDLTWQVMEKSK
YHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQDKPILEKISRGFLIDGRIFEFSRNAFNTDDYKFTLIARRRAH

Specific function: Represses mngA and mngB. Regulates its own expression [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=238, Percent_Identity=92.0168067226891, Blast_Score=459, Evalue=1e-131,
Organism=Escherichia coli, GI1790118, Length=231, Percent_Identity=29.004329004329, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI87082252, Length=163, Percent_Identity=31.2883435582822, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788418, Length=228, Percent_Identity=24.5614035087719, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790540, Length=201, Percent_Identity=26.865671641791, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28319; Mature: 28188

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
SIQGSGTYVKEERVNYDIFQLTSFDEKMSDRHIDTHSDVLVFEVILADDFLQQQLQISEQ
HHCCCCCEEEHHCCCCCCEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
DRVWHVKRVRYRKQKPMALEETWMPLSLFPDLTWQVMEKSKYHFIEEVKKMVIDRSEQEI
HHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IPLMPTEEMSRLLNISQDKPILEKISRGFLIDGRIFEFSRNAFNTDDYKFTLIARRRAH
ECCCCHHHHHHHHCCCCCCHHHHHHHCCEEECCEEEEECCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
GRKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
SIQGSGTYVKEERVNYDIFQLTSFDEKMSDRHIDTHSDVLVFEVILADDFLQQQLQISEQ
HHCCCCCEEEHHCCCCCCEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
DRVWHVKRVRYRKQKPMALEETWMPLSLFPDLTWQVMEKSKYHFIEEVKKMVIDRSEQEI
HHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IPLMPTEEMSRLLNISQDKPILEKISRGFLIDGRIFEFSRNAFNTDDYKFTLIARRRAH
ECCCCHHHHHHHHCCCCCCHHHHHHHCCEEECCEEEEECCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548486; 9278503; 9063979; 8905232; 7805834 [H]