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The map label for this gene is zitB [H]

Identifier: 218549682

GI number: 218549682

Start: 2413482

End: 2414417

Strand: Direct

Name: zitB [H]

Synonym: EFER_2358

Alternate gene names: 218549682

Gene position: 2413482-2414417 (Clockwise)

Preceding gene: 218549681

Following gene: 218549697

Centisome position: 52.6

GC content: 51.82

Gene sequence:

>936_bases
ATGGCACACTCACACAGTTCCTCACACCTGCCAGAAGATAATAATGCTCGTCGCTTGTTATATGCTTTCGGCGTGACTGC
CGGGTTTATGCTGGTAGAAGTCATTGGTGGTTTTCTTTCCGGTTCTCTGGCATTGCTGGCCGATGCGGGTCATATGTTGA
CCGATACTGCCGCCCTGCTTTTCGCCCTACTCGCCGTGCAATTTTCACGTCGCCCTCCCACCATTCGCCACACTTTCGGT
TGGCTAAGATTGACCACGCTCGCGGCGTTTGTGAATGCTATTGCTCTGGTGGTGATTACCATTTTGATTGTCTGGGAGGC
GATAGAACGCTTCCGCACGCCGCGTCCGGTCGAGGGTGGCATGATGATGGCTATTGCCGTGGCTGGGCTGCTGGCAAATA
TACTTTCTTTCTGGTTACTTCATCACGGCAGCGAAGAGAAAAACCTCAACGTGCGTGCAGCGGCACTGCATGTGCTCGGA
GACCTGCTGGGTTCGGTTGGGGCTATTATTGCCGCGTTGATTATTATCTGGACCGGCTGGACACCTGCTGACCCCATTCT
CTCAATACTGGTATCGCTTCTGGTTCTGCGTAGCGCCTGGCGGCTATTGAAAGACAGCGTGAATGAATTACTTGAAGGTG
CGCCAGTTTCGCTGGATATCGCTGAAATGAAACGTCGTATGTGCCGGGAAATTCCGGAAGTCCGTAATGTACACCATGTG
CATGTTTGGATGGTGGGTGAAAAGCCAGTGATGACACTACATGTACAGGTGATCCCGCCACACGATCACGACGCGTTGTT
GGATCAGATCCAACATTATCTGATGGATCACTATCAGATTGCACACGCCACCATCCAGATGGAATATCAACCTTGTCATG
GGCCAGACTGCCACCTGAACGAAGGCGTGTCTGGCCATTCACATCATCATCATTAA

Upstream 100 bases:

>100_bases
CCAATATTGGGAGAGCGGAGTCTCTCCTTTTTTATTTTTCTCTTCTAAAAGCAGTATGATGTCATAAAGTTAAGTGAGAA
TAATTAAGGGATGACTCGTC

Downstream 100 bases:

>100_bases
TGGGACAGCGCGCGTGAACCTCTTTCGCGTGCGCTGTTGATCCACATCCGGCTGCCGTTAAGGGCAATAAACGTCAGGAT
AATGTACTCCAGCGACATGG

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAHSHSSSHLPEDNNARRLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDTAALLFALLAVQFSRRPPTIRHTFG
WLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGGMMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLG
DLLGSVGAIIAALIIIWTGWTPADPILSILVSLLVLRSAWRLLKDSVNELLEGAPVSLDIAEMKRRMCREIPEVRNVHHV
HVWMVGEKPVMTLHVQVIPPHDHDALLDQIQHYLMDHYQIAHATIQMEYQPCHGPDCHLNEGVSGHSHHHH

Sequences:

>Translated_311_residues
MAHSHSSSHLPEDNNARRLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDTAALLFALLAVQFSRRPPTIRHTFG
WLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGGMMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLG
DLLGSVGAIIAALIIIWTGWTPADPILSILVSLLVLRSAWRLLKDSVNELLEGAPVSLDIAEMKRRMCREIPEVRNVHHV
HVWMVGEKPVMTLHVQVIPPHDHDALLDQIQHYLMDHYQIAHATIQMEYQPCHGPDCHLNEGVSGHSHHHH
>Mature_310_residues
AHSHSSSHLPEDNNARRLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDTAALLFALLAVQFSRRPPTIRHTFGW
LRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGGMMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLGD
LLGSVGAIIAALIIIWTGWTPADPILSILVSLLVLRSAWRLLKDSVNELLEGAPVSLDIAEMKRRMCREIPEVRNVHHVH
VWMVGEKPVMTLHVQVIPPHDHDALLDQIQHYLMDHYQIAHATIQMEYQPCHGPDCHLNEGVSGHSHHHH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas zntA is required for grow

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=308, Percent_Identity=32.4675324675325, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI289803013, Length=318, Percent_Identity=33.0188679245283, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI289803009, Length=318, Percent_Identity=33.0188679245283, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI289803007, Length=318, Percent_Identity=33.0188679245283, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI289803003, Length=318, Percent_Identity=33.0188679245283, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI64762489, Length=318, Percent_Identity=33.0188679245283, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=33.6569579288026, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI21359890, Length=289, Percent_Identity=31.4878892733564, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI20070323, Length=345, Percent_Identity=25.7971014492754, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI14210520, Length=231, Percent_Identity=29.004329004329, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI52352803, Length=132, Percent_Identity=43.1818181818182, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI52351208, Length=162, Percent_Identity=29.0123456790123, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=27.1317829457364, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=27.1317829457364, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=310, Percent_Identity=98.3870967741936, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1790349, Length=276, Percent_Identity=23.9130434782609, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193210990, Length=320, Percent_Identity=33.125, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17555794, Length=311, Percent_Identity=32.7974276527331, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555796, Length=306, Percent_Identity=32.6797385620915, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=31.023102310231, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17550440, Length=129, Percent_Identity=32.5581395348837, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17550442, Length=129, Percent_Identity=32.5581395348837, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=179, Percent_Identity=35.7541899441341, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323899, Length=132, Percent_Identity=36.3636363636364, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324892, Length=120, Percent_Identity=37.5, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24656728, Length=346, Percent_Identity=29.4797687861272, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24656724, Length=346, Percent_Identity=29.4797687861272, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24656720, Length=346, Percent_Identity=29.4797687861272, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24656715, Length=346, Percent_Identity=29.4797687861272, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI21357035, Length=346, Percent_Identity=29.4797687861272, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24583858, Length=321, Percent_Identity=29.2834890965732, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585900, Length=125, Percent_Identity=32.8, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24585898, Length=125, Percent_Identity=32.8, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24585896, Length=125, Percent_Identity=32.8, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19921672, Length=125, Percent_Identity=32.8, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24584409, Length=157, Percent_Identity=30.5732484076433, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28574430, Length=157, Percent_Identity=30.5732484076433, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645863, Length=127, Percent_Identity=30.7086614173228, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667550, Length=290, Percent_Identity=23.7931034482759, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667546, Length=290, Percent_Identity=23.7931034482759, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34415; Mature: 34284

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSHSSSHLPEDNNARRLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDTAALL
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHH
FALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLGDLLGSVGAIIAALIIIWTGW
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPADPILSILVSLLVLRSAWRLLKDSVNELLEGAPVSLDIAEMKRRMCREIPEVRNVHHV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCEEE
HVWMVGEKPVMTLHVQVIPPHDHDALLDQIQHYLMDHYQIAHATIQMEYQPCHGPDCHLN
EEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
EGVSGHSHHHH
CCCCCCCCCCC
>Mature Secondary Structure 
AHSHSSSHLPEDNNARRLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDTAALL
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHH
FALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLGDLLGSVGAIIAALIIIWTGW
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPADPILSILVSLLVLRSAWRLLKDSVNELLEGAPVSLDIAEMKRRMCREIPEVRNVHHV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCEEE
HVWMVGEKPVMTLHVQVIPPHDHDALLDQIQHYLMDHYQIAHATIQMEYQPCHGPDCHLN
EEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
EGVSGHSHHHH
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 11443104 [H]