The gene/protein map for NC_011740 is currently unavailable.
Definition Escherichia fergusonii ATCC 35469 chromosome, complete genome.
Accession NC_011740
Length 4,588,711

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The map label for this gene is rbtD [H]

Identifier: 218549508

GI number: 218549508

Start: 2219512

End: 2220264

Strand: Direct

Name: rbtD [H]

Synonym: EFER_2179

Alternate gene names: 218549508

Gene position: 2219512-2220264 (Clockwise)

Preceding gene: 218549506

Following gene: 218549509

Centisome position: 48.37

GC content: 51.39

Gene sequence:

>753_bases
ATGATGAATCACTCTGTGCCCTCTATGAATACTCCCCTTAATGGCAAAGTTGCGGCTATCACTGGCGCTGCGTCAGGTAT
TGGCCTGCAGTGTGCAAAAACGCTGCTTGATGCAGGAGCAAAGGTAGTATTGATTGACCGGGAAGGCGACAAACTGCAAA
AGATTGTCGCTGAGTTAGGTGAAAACGCGTACGCGCTGCAACTCGATCTCTTCAATAATCAGCAAGTCGATAACATGTTG
GCGGGCATTATCGAACTGGCGGGTGGGCTGGATATTTTTCATGCCAATGCAGGGGCTTACATTGGCGGCCCGGTGGCTGA
AGGTGATCCAGACGTCTGGGATCGCGTATTAAATCTGAATATAAATGCGGCGTTTCGCTGTGTCCGTGCTGTCCTGCCAC
ATATGATTGCGCAGAAATCGGGCGATATTATTTTTACCAGTTCCATCGCGGGCGTCGTTCCGGTTATCTGGGAACCGATC
TACACCGCGTCCAAATTTGCCGTTCAGGCGTTCGTACACACTACCCGCCGCCAGGTTTCTCAATATGGCGTACGTGTGGG
TGCGGTACTGCCAGGGCCGGTAGTCACTGCCCTGCTCGATGACTGGCCAAAAGCCAAAATGGAAGAAGCCCTGGCAAATG
GTAGCCTGATGCAACCGATTGAAGTGGCGGAATCAGTACTATTTATGGTGACACGCTCGAAAAATGTCACCGTGCGAGAT
TTAGTGATCCTGCCTGGCAGTGTCGATCTGTAA

Upstream 100 bases:

>100_bases
GCTTCATCGATTGAGCAGTTTGCTTCACACGCCAGCTAAATTCCCGTTCAGTGCGTGCCAGCAAACAGAGACTATAAATT
CGCCCTGGTAAAAGGATTAT

Downstream 100 bases:

>100_bases
GGGCGCAATCATGACAATAACCAAAACCGTTATTGGTGTTGATGTGGGATCAGGCAGTGTCCGCGCCGGGATTTTTGATC
TCAACGGATCTCTGCTATCC

Product: Ribitol 2-dehydrogenase

Products: NA

Alternate protein names: RDH [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MMNHSVPSMNTPLNGKVAAITGAASGIGLQCAKTLLDAGAKVVLIDREGDKLQKIVAELGENAYALQLDLFNNQQVDNML
AGIIELAGGLDIFHANAGAYIGGPVAEGDPDVWDRVLNLNINAAFRCVRAVLPHMIAQKSGDIIFTSSIAGVVPVIWEPI
YTASKFAVQAFVHTTRRQVSQYGVRVGAVLPGPVVTALLDDWPKAKMEEALANGSLMQPIEVAESVLFMVTRSKNVTVRD
LVILPGSVDL

Sequences:

>Translated_250_residues
MMNHSVPSMNTPLNGKVAAITGAASGIGLQCAKTLLDAGAKVVLIDREGDKLQKIVAELGENAYALQLDLFNNQQVDNML
AGIIELAGGLDIFHANAGAYIGGPVAEGDPDVWDRVLNLNINAAFRCVRAVLPHMIAQKSGDIIFTSSIAGVVPVIWEPI
YTASKFAVQAFVHTTRRQVSQYGVRVGAVLPGPVVTALLDDWPKAKMEEALANGSLMQPIEVAESVLFMVTRSKNVTVRD
LVILPGSVDL
>Mature_250_residues
MMNHSVPSMNTPLNGKVAAITGAASGIGLQCAKTLLDAGAKVVLIDREGDKLQKIVAELGENAYALQLDLFNNQQVDNML
AGIIELAGGLDIFHANAGAYIGGPVAEGDPDVWDRVLNLNINAAFRCVRAVLPHMIAQKSGDIIFTSSIAGVVPVIWEPI
YTASKFAVQAFVHTTRRQVSQYGVRVGAVLPGPVVTALLDDWPKAKMEEALANGSLMQPIEVAESVLFMVTRSKNVTVRD
LVILPGSVDL

Specific function: Unknown

COG id: COG4221

COG function: function code R; Short-chain alcohol dehydrogenase of unknown specificity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=246, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=26.7716535433071, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7657478, Length=188, Percent_Identity=33.5106382978723, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI109715829, Length=244, Percent_Identity=27.0491803278689, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706318, Length=197, Percent_Identity=29.4416243654822, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI157739938, Length=243, Percent_Identity=26.3374485596708, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI66933014, Length=195, Percent_Identity=34.3589743589744, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=28.042328042328, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7705855, Length=192, Percent_Identity=32.8125, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=32.9411764705882, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI5031737, Length=189, Percent_Identity=28.042328042328, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI40254992, Length=215, Percent_Identity=24.6511627906977, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI142976729, Length=250, Percent_Identity=25.2, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI126723191, Length=192, Percent_Identity=27.6041666666667, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4503817, Length=226, Percent_Identity=25.6637168141593, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI223718074, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI15277342, Length=238, Percent_Identity=26.890756302521, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32455239, Length=182, Percent_Identity=31.3186813186813, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI5031765, Length=182, Percent_Identity=31.3186813186813, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI19923817, Length=239, Percent_Identity=23.8493723849372, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI210032110, Length=252, Percent_Identity=24.6031746031746, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI22507405, Length=196, Percent_Identity=31.1224489795918, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=24.5614035087719, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=23.8866396761134, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787820, Length=234, Percent_Identity=30.3418803418803, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082100, Length=233, Percent_Identity=30.4721030042918, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787335, Length=222, Percent_Identity=28.8288288288288, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=200, Percent_Identity=28, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787526, Length=206, Percent_Identity=32.0388349514563, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=27.9166666666667, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1787905, Length=232, Percent_Identity=30.6034482758621, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786701, Length=207, Percent_Identity=28.0193236714976, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789208, Length=187, Percent_Identity=31.5508021390374, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789378, Length=242, Percent_Identity=26.0330578512397, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=25.0996015936255, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=244, Percent_Identity=29.9180327868852, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=246, Percent_Identity=30.0813008130081, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=246, Percent_Identity=29.2682926829268, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=246, Percent_Identity=29.2682926829268, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=247, Percent_Identity=28.3400809716599, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=229, Percent_Identity=28.3842794759825, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=31.0606060606061, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=243, Percent_Identity=29.2181069958848, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=246, Percent_Identity=27.6422764227642, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=27.0992366412214, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=242, Percent_Identity=26.8595041322314, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=248, Percent_Identity=26.2096774193548, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=241, Percent_Identity=26.1410788381743, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=244, Percent_Identity=25, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=244, Percent_Identity=25.4098360655738, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=24.4186046511628, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=232, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=246, Percent_Identity=26.0162601626016, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=254, Percent_Identity=25.5905511811024, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=243, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555612, Length=236, Percent_Identity=27.9661016949153, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=25.9067357512953, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=249, Percent_Identity=29.718875502008, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322067, Length=192, Percent_Identity=26.5625, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322227, Length=196, Percent_Identity=29.5918367346939, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358495, Length=243, Percent_Identity=30.4526748971193, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571387, Length=241, Percent_Identity=29.4605809128631, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=226, Percent_Identity=31.4159292035398, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21355319, Length=233, Percent_Identity=29.6137339055794, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24641232, Length=246, Percent_Identity=29.6747967479675, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=29.9180327868852, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571526, Length=235, Percent_Identity=28.936170212766, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357041, Length=219, Percent_Identity=30.5936073059361, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24663911, Length=244, Percent_Identity=28.2786885245902, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24643142, Length=220, Percent_Identity=33.1818181818182, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24641388, Length=254, Percent_Identity=28.740157480315, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648944, Length=239, Percent_Identity=28.0334728033473, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007236, Length=246, Percent_Identity=26.4227642276423, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281364892, Length=231, Percent_Identity=27.7056277056277, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24580925, Length=202, Percent_Identity=28.2178217821782, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644339, Length=230, Percent_Identity=29.1304347826087, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640442, Length=193, Percent_Identity=30.0518134715026, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281364494, Length=246, Percent_Identity=26.4227642276423, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24665243, Length=199, Percent_Identity=29.1457286432161, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221331218, Length=201, Percent_Identity=28.8557213930348, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24665247, Length=200, Percent_Identity=29.5, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221331216, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648693, Length=253, Percent_Identity=26.8774703557312, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355889, Length=253, Percent_Identity=26.8774703557312, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI116007238, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356301, Length=224, Percent_Identity=26.7857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=201, Percent_Identity=28.3582089552239, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007234, Length=245, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574402, Length=192, Percent_Identity=28.6458333333333, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584744, Length=192, Percent_Identity=28.6458333333333, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=26.8421052631579, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24649181, Length=185, Percent_Identity=25.4054054054054, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.56 [H]

Molecular weight: Translated: 26598; Mature: 26598

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MMNHSVPSMNTPLNGKVAAITGAASGIGLQCAKTLLDAGAKVVLIDREGDKLQKIVAELG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHC
ENAYALQLDLFNNQQVDNMLAGIIELAGGLDIFHANAGAYIGGPVAEGDPDVWDRVLNLN
CCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCHHHHHHHHCCC
INAAFRCVRAVLPHMIAQKSGDIIFTSSIAGVVPVIWEPIYTASKFAVQAFVHTTRRQVS
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QYGVRVGAVLPGPVVTALLDDWPKAKMEEALANGSLMQPIEVAESVLFMVTRSKNVTVRD
HHCEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCCEEEE
LVILPGSVDL
EEEECCCCCC
>Mature Secondary Structure
MMNHSVPSMNTPLNGKVAAITGAASGIGLQCAKTLLDAGAKVVLIDREGDKLQKIVAELG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHC
ENAYALQLDLFNNQQVDNMLAGIIELAGGLDIFHANAGAYIGGPVAEGDPDVWDRVLNLN
CCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCHHHHHHHHCCC
INAAFRCVRAVLPHMIAQKSGDIIFTSSIAGVVPVIWEPIYTASKFAVQAFVHTTRRQVS
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QYGVRVGAVLPGPVVTALLDDWPKAKMEEALANGSLMQPIEVAESVLFMVTRSKNVTVRD
HHCEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCCEEEE
LVILPGSVDL
EEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3904726; 2933028; 3891331 [H]