Click here to switch to the map view.

The map label for this gene is vanR [H]

Identifier: 218236069

GI number: 218236069

Start: 2445120

End: 2445815

Strand: Reverse

Name: vanR [H]

Synonym: BCB4264_A2526

Alternate gene names: 218236069

Gene position: 2445815-2445120 (Counterclockwise)

Preceding gene: 218234187

Following gene: 218231270

Centisome position: 45.13

GC content: 31.47

Gene sequence:

>696_bases
ATGAATAAAAACATATTAATTATTGATGATGATAAAGAAATTGTTGAATTACTTGCTGTTTATTTGCGAAATGAAGGCTA
TAACATTTATAAAGCTTATGATGGCGATGAAGCATTGCAAAAGGTTTCTACATATGAAGTTGACCTTATGATTTTGGATA
TTATGATGCCAAAACGAAACGGATTAGAAGTTTGTCAGGAAGTGCGTGAAAATAATACTGTACCAATTCTAATGCTTAGT
GCAAAAGCAGAAGATATGGATAAAATATTAGGCCTTATGACAGGTGCCGATGATTATATGATCAAACCATTCAATCCATT
AGAATTAGTAGCTAGAGTGAAAGCTTTATTACGAAGATCCTCTTTCCAAAATGCTACTTCGCAAAAGAATGAAGATGGTA
TTATTCGTATTCGCTCTGTTGAAATACACAAACATAATCATACAGTTAAAGTAAATGGAGAGTACATTAAACTAACCTCT
ATTGAATTCGATATTTTATATTTACTTGCGAGTAATACAGGAAGAGTATTTAGTTCAGAAGAAATTTTCGAACGCGTTTG
GAATGAAGATGGTTATGGTTCAAATAAGACGGTAATGGTCCATATTAGCAACTTACGAGATAAACTTGAAACAGTAATAA
ATGGAGAAAAATTTATTCATACTGTTTGGGGAGTTGGCTATAAAATTGAGAAATGA

Upstream 100 bases:

>100_bases
TAATACGTTACATGAAATTTTATACAGAATCATCGCTACAAGTACATAAATGTTTGATATTATAGTAATGTTGATGATTT
GTAAGGAAAGGAACTACACA

Downstream 100 bases:

>100_bases
AGCATTTGATATATTAAAAGATATTCCTAAATGGAAACTTATTTTTTGGCTTTTATTAGCTATCACACTCACTCCTATTA
CTGAATTAATTATTTATCGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVINGEKFIHTVWGVGYKIEK

Sequences:

>Translated_231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVINGEKFIHTVWGVGYKIEK
>Mature_231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVINGEKFIHTVWGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=36.6812227074236, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.5545851528384, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=33.6206896551724, Blast_Score=146, Evalue=9e-37,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=31.4159292035398, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=33.1914893617021, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=32.3144104803493, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=33.6322869955157, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.1896551724138, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=33.0396475770925, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=33.1858407079646, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=33.4801762114537, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=30.8370044052863, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=28.82096069869, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790437, Length=105, Percent_Identity=34.2857142857143, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787487, Length=124, Percent_Identity=33.8709677419355, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=102, Percent_Identity=38.2352941176471, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26550; Mature: 26550

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTYEVDLMILDIMMPKRN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEEEEEEEEECCCCC
GLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRS
CHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSE
HCCCCCCCCCCCCEEEEEEEEEEECCCEEEECCCEEEEEEEEEEEEEEEECCCCCEECHH
EIFERVWNEDGYGSNKTVMVHISNLRDKLETVINGEKFIHTVWGVGYKIEK
HHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHEEHHHCCCEEECC
>Mature Secondary Structure
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTYEVDLMILDIMMPKRN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEEEEEEEEECCCCC
GLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRS
CHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSE
HCCCCCCCCCCCCEEEEEEEEEEECCCEEEECCCEEEEEEEEEEEEEEEECCCCCEECHH
EIFERVWNEDGYGSNKTVMVHISNLRDKLETVINGEKFIHTVWGVGYKIEK
HHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHEEHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]