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The map label for this gene is mco [H]

Identifier: 218236048

GI number: 218236048

Start: 1815614

End: 1817254

Strand: Direct

Name: mco [H]

Synonym: BCB4264_A1908

Alternate gene names: 218236048

Gene position: 1815614-1817254 (Clockwise)

Preceding gene: 218235934

Following gene: 218235463

Centisome position: 33.5

GC content: 35.16

Gene sequence:

>1641_bases
ATGAAGCGATTTGTATTAACAGCTGTTACGGTCTCTGTAATATTTTTAATTGCTGCATGTTCTTTGGCCACAAATACAAC
AAATGATCATAAAAATATGAAAGATAAAAAAACAATACAGGCTGAAACAGCTACAAAACCATTGAAGATTGAAAAAGGAC
CAGAAGTTACTTTAGTAGCGAAAGAAGAAAAGCAAAAGTTAGGTAACGGTGTTATTGTTCCAGTCTGGACATTTAATGGC
TCATCACCTGGTCCAGAAATTCGGGTGAAAAAAGGTGAAAAGGTGAAAGTGACATTAAAAAATGAATTATCTGCACCAGT
ATCTATTCATTGGCATGGATATCCTGTCCCAAATAACATGGATGGAATTCCAGGCGTGACACAAGATGCAGTTGAACCAG
GAAAAAGTTTCACTTACGAATTTGAAGCGAACGTACCAGGAACGTACTGGTATCACTCGCATCAAGATTCTGTAAATCAA
TTAGATAGAGGTTTGTATGGAGCACTTATTGTAGAAGATACAAAGGAAAAATATGATAAAGATTACACATTAATGTTGGA
TGAATGGGTTACAGATAAAAAAGAAATGAATAAGCAGTTAAAAGAAATGACAAAAGGGCAAATAGGTAATAAATCTAAAG
GTAATGAAAATGAGGAAAAGAATAATGATAAGAACGGCATGGCTCATTCTGGTATGGACATGGGCAGTGATCAAAAAGAC
TCTGGCAATATGGCAGGAATGGACCATGGAAATATGAAGATGGAAGGTCATGATATGAGTATGTATGATTTATTCACAAT
CAATGGAAAAAGCGGTGATTTAGTAGTGCCATTGAAAGTGAATAAGGGAGAAAAAGTTCGTCTTCGACTCATTAATGCTG
GTTATCTATCACATGATATACATGTTCACGGTCATGATATAAAAGTAATTGCGACAGATGGTCAACCAATAAATGATCCA
AAAGTTATAAAGGATAAAGTAATTTCAATCGCACCGGGTGAACGTTATGATATTGAATTTACTGCTAATAAAACTGGGAA
ATGGTATGTTGAAGACCATTCGAAAAATAAAGGTGCAAAAGGAATGAAAGCTGTTATTGAATATGATGGCAGCAAAGAGA
TGAAAGATAAAGCAGACGAAAAAGAAAAATTACCGAAAGTAGATATCATGAAATATGGTACTAAAAAATTAGGAAGTTTC
CCGTTAAATCAAGAGTATACTGCCACATATAATATGGACTTAAATACGCAAATGAATGGAAATGAAATGGTATATACAAT
TAACGGAAAGGTATTTCCGGATATTGACCCAATTCAAGTAAAAAAGGGTGATTTAGTAAAAGTGAAGTTGGTAAATCGTT
CTAAAATGGATGATCACCCAATGCATTTACATGGTCATTTCTTCCAGGTGTTGAGTAAAGATGGAAAACCGATAGAAGGT
TCTCCGATTGTTAAAGACACATTGAATTTGAGGCCAGGAGAAGAATATGAAGTAGCCTTTGTAGCAGACAATCCTGGCGA
GTGGATGTTCCACTGTCACGACCTACATCATGCTTCAGCAGGGATGGTAACGGAAGTGAACTATACAGATTATGAATCTA
GTTATGTTCCAAACCCTAATATTCCTAATAAACCAGAATAA

Upstream 100 bases:

>100_bases
AATCTTCCAATTAGCTTACGTATTATCTAATTACATCTCCTTATTTTCTTGAAAATCAAGTTCTATAATGATTTTGAAAA
AGAAAAAGGAGGGATTTTCC

Downstream 100 bases:

>100_bases
TGTGAAAATCATGTAGTTTATTAATGATGAAAGCAGTTATCTTAATAGGTTGCTGCTTTTATATGTCATGTTGTGAATTG
GGAATATTATTTTTATAAAA

Product: multicopper oxidase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKRFVLTAVTVSVIFLIAACSLATNTTNDHKNMKDKKTIQAETATKPLKIEKGPEVTLVAKEEKQKLGNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNNMDGIPGVTQDAVEPGKSFTYEFEANVPGTYWYHSHQDSVNQ
LDRGLYGALIVEDTKEKYDKDYTLMLDEWVTDKKEMNKQLKEMTKGQIGNKSKGNENEEKNNDKNGMAHSGMDMGSDQKD
SGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVVPLKVNKGEKVRLRLINAGYLSHDIHVHGHDIKVIATDGQPINDP
KVIKDKVISIAPGERYDIEFTANKTGKWYVEDHSKNKGAKGMKAVIEYDGSKEMKDKADEKEKLPKVDIMKYGTKKLGSF
PLNQEYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPIQVKKGDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKPIEG
SPIVKDTLNLRPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVNYTDYESSYVPNPNIPNKPE

Sequences:

>Translated_546_residues
MKRFVLTAVTVSVIFLIAACSLATNTTNDHKNMKDKKTIQAETATKPLKIEKGPEVTLVAKEEKQKLGNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNNMDGIPGVTQDAVEPGKSFTYEFEANVPGTYWYHSHQDSVNQ
LDRGLYGALIVEDTKEKYDKDYTLMLDEWVTDKKEMNKQLKEMTKGQIGNKSKGNENEEKNNDKNGMAHSGMDMGSDQKD
SGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVVPLKVNKGEKVRLRLINAGYLSHDIHVHGHDIKVIATDGQPINDP
KVIKDKVISIAPGERYDIEFTANKTGKWYVEDHSKNKGAKGMKAVIEYDGSKEMKDKADEKEKLPKVDIMKYGTKKLGSF
PLNQEYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPIQVKKGDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKPIEG
SPIVKDTLNLRPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVNYTDYESSYVPNPNIPNKPE
>Mature_546_residues
MKRFVLTAVTVSVIFLIAACSLATNTTNDHKNMKDKKTIQAETATKPLKIEKGPEVTLVAKEEKQKLGNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNNMDGIPGVTQDAVEPGKSFTYEFEANVPGTYWYHSHQDSVNQ
LDRGLYGALIVEDTKEKYDKDYTLMLDEWVTDKKEMNKQLKEMTKGQIGNKSKGNENEEKNNDKNGMAHSGMDMGSDQKD
SGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVVPLKVNKGEKVRLRLINAGYLSHDIHVHGHDIKVIATDGQPINDP
KVIKDKVISIAPGERYDIEFTANKTGKWYVEDHSKNKGAKGMKAVIEYDGSKEMKDKADEKEKLPKVDIMKYGTKKLGSF
PLNQEYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPIQVKKGDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKPIEG
SPIVKDTLNLRPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVNYTDYESSYVPNPNIPNKPE

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=185, Percent_Identity=28.6486486486486, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320714, Length=553, Percent_Identity=26.2206148282098, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321067, Length=504, Percent_Identity=23.015873015873, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323703, Length=125, Percent_Identity=40, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574104, Length=362, Percent_Identity=26.2430939226519, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281360167, Length=338, Percent_Identity=25.7396449704142, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24585842, Length=339, Percent_Identity=26.2536873156342, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI221330000, Length=322, Percent_Identity=27.0186335403727, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI221329998, Length=338, Percent_Identity=25.7396449704142, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24650186, Length=153, Percent_Identity=33.9869281045752, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859919, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 61157; Mature: 61157

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFVLTAVTVSVIFLIAACSLATNTTNDHKNMKDKKTIQAETATKPLKIEKGPEVTLVA
CCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEHHCCCCCEEECCCCCEEEEE
KEEKQKLGNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNNM
CHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVPGTYWYHSHQDSVNQLDRGLYGALIVEDTKEKYDK
CCCCCCCHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHCCCEEEEEEECCHHHHCC
DYTLMLDEWVTDKKEMNKQLKEMTKGQIGNKSKGNENEEKNNDKNGMAHSGMDMGSDQKD
CEEEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVVPLKVNKGEKVRLRLINAGYLSHDI
CCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEE
HVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDIEFTANKTGKWYVEDHSKNKGAK
EEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCC
GMKAVIEYDGSKEMKDKADEKEKLPKVDIMKYGTKKLGSFPLNQEYTATYNMDLNTQMNG
CEEEEEEECCCCHHHHHCCHHHHCCCEEEEHHCCHHHCCCCCCCCEEEEEEEEECCEECC
NEMVYTINGKVFPDIDPIQVKKGDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKPIEG
CEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHCCCCCCCCC
SPIVKDTLNLRPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVNYTDYESSYVPNPN
CCCCHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCC
IPNKPE
CCCCCC
>Mature Secondary Structure
MKRFVLTAVTVSVIFLIAACSLATNTTNDHKNMKDKKTIQAETATKPLKIEKGPEVTLVA
CCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEHHCCCCCEEECCCCCEEEEE
KEEKQKLGNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNNM
CHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVPGTYWYHSHQDSVNQLDRGLYGALIVEDTKEKYDK
CCCCCCCHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHCCCEEEEEEECCHHHHCC
DYTLMLDEWVTDKKEMNKQLKEMTKGQIGNKSKGNENEEKNNDKNGMAHSGMDMGSDQKD
CEEEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVVPLKVNKGEKVRLRLINAGYLSHDI
CCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEE
HVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDIEFTANKTGKWYVEDHSKNKGAK
EEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCC
GMKAVIEYDGSKEMKDKADEKEKLPKVDIMKYGTKKLGSFPLNQEYTATYNMDLNTQMNG
CEEEEEEECCCCHHHHHCCHHHHCCCEEEEHHCCHHHCCCCCCCCEEEEEEEEECCEECC
NEMVYTINGKVFPDIDPIQVKKGDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKPIEG
CEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHCCCCCCCCC
SPIVKDTLNLRPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVNYTDYESSYVPNPN
CCCCHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCC
IPNKPE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]