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The map label for this gene is pepP [H]

Identifier: 218235934

GI number: 218235934

Start: 1813234

End: 1814517

Strand: Direct

Name: pepP [H]

Synonym: BCB4264_A1906

Alternate gene names: 218235934

Gene position: 1813234-1814517 (Clockwise)

Preceding gene: 218233817

Following gene: 218236048

Centisome position: 33.46

GC content: 32.32

Gene sequence:

>1284_bases
ATGAAATCAACATTTTTTGCTCAAAATAGAGAACGATTAGCAAACATATTACCAGAGGGATCTATTACGATATTATTTGC
GGGACAAGCACCGCATATGTCAGCTGATGCACATTATAAATTTGTACCGAATCGTAATTTTTACTACTTAACGGGAATCG
ATGAACCAAATGTTATTTTTATGCTGAAAAAGGTTGGAAGTAGTGTTGAAGAAACACTTTTCATTGAAAAGTCAGATCCA
GTAATGGAAAAATGGGTCGGTAAAACAGTTTCTAACGAAGAAGCAGAGAAAATTTCAGGTATAAAGAAAGTTGTATATTT
AGATAGCTTTGAAAAGACAATGTCAAATATACTTTTTACAGAAAATGCGAAGCATCTATATTTAGATATAGAACGTCGTG
ATTGGAATGGTACGGAGACAAAAACATTAGCATTTGCTAAACATGTAAGAGAAAAATACCCACACGTAACAATTGGTAAT
GTATATCCGAACATTTGTGAATTACGAGTATTTAAAACAGAGGAAGAAATTGAAATTATTAAAGAAGCGATTGCTATAAC
GAAAGACGGTATTTACAACGTACTTAAGCATGCAAAAGCAGGCATGATGGAGTATGAATTAGAAGCACAATTTGATTTTA
CGCTGAAGTCATCTGGCATTAAGTACCATGCGTTCAATACAATTTTGGCGAGTGGGAAAAATGCTACAGTTCTTCATTAT
GAAGATAATGATGCACAAATTCAAAATGGTGACTTAGTATTACTAGATTTAGGTGCTCAAAAAGACTACTATAACGCTGA
TATTAGTTATACATTCCCGGCAAATGGAATATTCTCTAGTCGTCAAAAACAAATTTATAATATTGTATTAAAAGCATTAA
AAGAAACAACAGCACTTATTAAGCCAGGATTAAAGTTCGCTGCATTAAATGAGCATACAAAAAAGGTACTAGTAGAAGAG
TGTAAAGCAATCGGTTTAATTCAAGAAGATGAAGAGTTATCAAAATACTATTATCATGGTGTCAGCCATTTCCTTGGTTT
AGATACACATGATGTAGGAACATATAAAGATAGAGTGTTAGAAGAAGGTATGGTTATAACAATTGAACCTGGTCTTTATA
TTGAAGGAGAATCAATTGGAATTCGTATTGAAGATGACATTCTTGTAACGAAAGACGGGTATGAAAACTTGTCAAAAGAT
ATCATTAGGGAAGTTGAAGAAATTGAAGAATTTATGAGTGTAAATAATGAACATGTAAAAGGAAACCAAGCTGTAGTTAA
ATAA

Upstream 100 bases:

>100_bases
CTATGAGTACTATTAATTGACGAAAAATTATAACAATAATAGAATGAATTGTATTGATGATTAGTTTCACAAGCATACAT
AGAACACTAGGGGGATTATT

Downstream 100 bases:

>100_bases
TAAAAGAGTCATCACTAATTTATTTGAACTTTATCTCGAATCGTGGACAATTAAAAAATCCATGATTCGGGATAGGGTTC
TTTTCTTCGAAATACTAATC

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKSTFFAQNRERLANILPEGSITILFAGQAPHMSADAHYKFVPNRNFYYLTGIDEPNVIFMLKKVGSSVEETLFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVVYLDSFEKTMSNILFTENAKHLYLDIERRDWNGTETKTLAFAKHVREKYPHVTIGN
VYPNICELRVFKTEEEIEIIKEAIAITKDGIYNVLKHAKAGMMEYELEAQFDFTLKSSGIKYHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGIFSSRQKQIYNIVLKALKETTALIKPGLKFAALNEHTKKVLVEE
CKAIGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEGESIGIRIEDDILVTKDGYENLSKD
IIREVEEIEEFMSVNNEHVKGNQAVVK

Sequences:

>Translated_427_residues
MKSTFFAQNRERLANILPEGSITILFAGQAPHMSADAHYKFVPNRNFYYLTGIDEPNVIFMLKKVGSSVEETLFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVVYLDSFEKTMSNILFTENAKHLYLDIERRDWNGTETKTLAFAKHVREKYPHVTIGN
VYPNICELRVFKTEEEIEIIKEAIAITKDGIYNVLKHAKAGMMEYELEAQFDFTLKSSGIKYHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGIFSSRQKQIYNIVLKALKETTALIKPGLKFAALNEHTKKVLVEE
CKAIGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEGESIGIRIEDDILVTKDGYENLSKD
IIREVEEIEEFMSVNNEHVKGNQAVVK
>Mature_427_residues
MKSTFFAQNRERLANILPEGSITILFAGQAPHMSADAHYKFVPNRNFYYLTGIDEPNVIFMLKKVGSSVEETLFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVVYLDSFEKTMSNILFTENAKHLYLDIERRDWNGTETKTLAFAKHVREKYPHVTIGN
VYPNICELRVFKTEEEIEIIKEAIAITKDGIYNVLKHAKAGMMEYELEAQFDFTLKSSGIKYHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGIFSSRQKQIYNIVLKALKETTALIKPGLKFAALNEHTKKVLVEE
CKAIGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEGESIGIRIEDDILVTKDGYENLSKD
IIREVEEIEEFMSVNNEHVKGNQAVVK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=472, Percent_Identity=28.3898305084746, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI11559925, Length=402, Percent_Identity=29.8507462686567, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI260593665, Length=306, Percent_Identity=32.6797385620915, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI260593663, Length=472, Percent_Identity=25.4237288135593, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI264681563, Length=248, Percent_Identity=27.8225806451613, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789275, Length=433, Percent_Identity=32.1016166281755, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788728, Length=242, Percent_Identity=30.9917355371901, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790282, Length=291, Percent_Identity=25.4295532646048, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=473, Percent_Identity=31.5010570824524, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71989583, Length=371, Percent_Identity=24.7978436657682, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320922, Length=441, Percent_Identity=28.3446712018141, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321118, Length=431, Percent_Identity=29.4663573085847, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21357079, Length=481, Percent_Identity=30.7692307692308, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI19920384, Length=425, Percent_Identity=28.2352941176471, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48570; Mature: 48570

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTFFAQNRERLANILPEGSITILFAGQAPHMSADAHYKFVPNRNFYYLTGIDEPNVIF
CCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEECCCCCCEEE
MLKKVGSSVEETLFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVVYLDSFEKTMSNILFT
EEHHHCCCHHHEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHEEEEHHHHHHHHHEEEE
ENAKHLYLDIERRDWNGTETKTLAFAKHVREKYPHVTIGNVYPNICELRVFKTEEEIEII
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHH
KEAIAITKDGIYNVLKHAKAGMMEYELEAQFDFTLKSSGIKYHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCEEEEEEHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGIFSSRQKQIYNIVLKALKETTALI
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFAALNEHTKKVLVEECKAIGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEGESIGIRIEDDILVTKDGYENLSKDIIREVEEIEEFMSVNNEHVK
HCCEEEEECCCEEEECCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNQAVVK
CCCEECC
>Mature Secondary Structure
MKSTFFAQNRERLANILPEGSITILFAGQAPHMSADAHYKFVPNRNFYYLTGIDEPNVIF
CCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEECCCCCCEEE
MLKKVGSSVEETLFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVVYLDSFEKTMSNILFT
EEHHHCCCHHHEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHEEEEHHHHHHHHHEEEE
ENAKHLYLDIERRDWNGTETKTLAFAKHVREKYPHVTIGNVYPNICELRVFKTEEEIEII
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHH
KEAIAITKDGIYNVLKHAKAGMMEYELEAQFDFTLKSSGIKYHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCEEEEEEHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGIFSSRQKQIYNIVLKALKETTALI
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFAALNEHTKKVLVEECKAIGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEGESIGIRIEDDILVTKDGYENLSKDIIREVEEIEEFMSVNNEHVK
HCCEEEEECCCEEEECCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNQAVVK
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]