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The map label for this gene is hisD [H]

Identifier: 218234866

GI number: 218234866

Start: 1401524

End: 1402813

Strand: Direct

Name: hisD [H]

Synonym: BCB4264_A1459

Alternate gene names: 218234866

Gene position: 1401524-1402813 (Clockwise)

Preceding gene: 218234195

Following gene: 218235800

Centisome position: 25.86

GC content: 37.75

Gene sequence:

>1290_bases
ATGGAAATCATTTATGAAGAATTTAAGGGGGCATTATCTAAAATAAAAGTGCTAAGAGAAAACGCTAATATAATAGAAGA
AACTGTTCAAAGAAGTGTAAGAGAAATCATTAGAAATGTAAGGGAAGGGAAAGATGAAGCTTTATCTTTCTATACAAAAA
AGTTTGATGGTGTAGAGATGAAAGATTTTCGTGTAAGTGAAGAAGAAATACAGCAAGCGAGTATGTTTGTAGAGAATTCA
TTTTTAGAAGCTTTAAAAGAGGCGAAGAAAAACATTGTTTCGTATCACGAAAAGCAAAAGAAGCACTCAATATTCGATTG
TGAAAGTAAAGGCATAATTAGAGGGCAACTCATTCGGCCGTTAGAAAATGTAGGTGTATATGTACCGGGTGGGACAGCCT
CATATCCTTCTTCAGTATTAATGAATGTATTGCCGGCGAAACTCGCAGGTGTGAAAAAGATTGTAATGGTAACACCGCCG
AGGAAAGGAGGAATTGATCCGCATATATTAGCTGCTGCAAATCTTGCGGGAGTAGATGAAATTTATACGATAGGTGGCGC
GCAAGCAATTGCTGCTTTAGCATACGGGACGGAATCGATTCCGAAAGTGGATAAAATAGTTGGACCGGGAAATTTGTATG
TCGCTCTAGCGAAGCGAGAAGTATACGGAATAGTAAATATCGATATGATTGCTGGTCCATCAGAAATTGTAGTTGTCGCG
GATGAAACAGGTAATGCAAAATATATCGCAGCGGATTTATTATCGCAAGCAGAGCATGATGAGAGAGCAACGGCGATTTG
TATTACAATGAATATGGAACTAGCTAAAGAAGTAGAAAAAGAGGTAGAAAGACAGTTAGAAACGTTACCAAGAAGTGAAA
TTGCACGTGAATCAATAAATAGAAATGGAGCCATCTTTATCGTTCCTTCTTTAGAGGAGGCACTAAAGTTATCAAATGAA
ATTGCTCCAGAACATTTAGAGTTACATATAAAAGAACCAATGAATGCTCTAGATTATGTGAAACATGCAGGCTCTATTTT
CCTTGGGCCATATTCACCTGAACCGCTCGGGGATTATTTAGCGGGACCGAATCATGTATTACCAACGAGCGGAACGGCAA
GATTTTTTTCTCCGTTATCAGTCGATGATTTCGTGAAAAAATCAAGTTTTATTTCTTATACGGAGGAGGCATTAAAAAAT
GTACAGCATCATATTGTAGAGCTTGCAAATAAAGAAGGGTTACATGCACATGCGAGAGCAATCCAAATAAGGTTTGAGGA
GGAAAAATAA

Upstream 100 bases:

>100_bases
TTGTAAATAAGGCAGCCTTAAAAACTAAAAAAGACGAAATATTCAGCATTATAAATATGATGGAGCAAGAAATCTTATCA
GGGAAATAGGAGGATTTAAA

Downstream 100 bases:

>100_bases
TGCGTCAGTCCAGTCAAGTACGTGAGACGAAAGAAACAAAAATTAAATTAAATTTGCAGCTTGATGAAAGTACAAATGTA
TCTATTCAAACAGGGGTTGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEIIYEEFKGALSKIKVLRENANIIEETVQRSVREIIRNVREGKDEALSFYTKKFDGVEMKDFRVSEEEIQQASMFVENS
FLEALKEAKKNIVSYHEKQKKHSIFDCESKGIIRGQLIRPLENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RKGGIDPHILAAANLAGVDEIYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVVA
DETGNAKYIAADLLSQAEHDERATAICITMNMELAKEVEKEVERQLETLPRSEIARESINRNGAIFIVPSLEEALKLSNE
IAPEHLELHIKEPMNALDYVKHAGSIFLGPYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFISYTEEALKN
VQHHIVELANKEGLHAHARAIQIRFEEEK

Sequences:

>Translated_429_residues
MEIIYEEFKGALSKIKVLRENANIIEETVQRSVREIIRNVREGKDEALSFYTKKFDGVEMKDFRVSEEEIQQASMFVENS
FLEALKEAKKNIVSYHEKQKKHSIFDCESKGIIRGQLIRPLENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RKGGIDPHILAAANLAGVDEIYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVVA
DETGNAKYIAADLLSQAEHDERATAICITMNMELAKEVEKEVERQLETLPRSEIARESINRNGAIFIVPSLEEALKLSNE
IAPEHLELHIKEPMNALDYVKHAGSIFLGPYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFISYTEEALKN
VQHHIVELANKEGLHAHARAIQIRFEEEK
>Mature_429_residues
MEIIYEEFKGALSKIKVLRENANIIEETVQRSVREIIRNVREGKDEALSFYTKKFDGVEMKDFRVSEEEIQQASMFVENS
FLEALKEAKKNIVSYHEKQKKHSIFDCESKGIIRGQLIRPLENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RKGGIDPHILAAANLAGVDEIYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVVA
DETGNAKYIAADLLSQAEHDERATAICITMNMELAKEVEKEVERQLETLPRSEIARESINRNGAIFIVPSLEEALKLSNE
IAPEHLELHIKEPMNALDYVKHAGSIFLGPYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFISYTEEALKN
VQHHIVELANKEGLHAHARAIQIRFEEEK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=402, Percent_Identity=42.5373134328358, Blast_Score=318, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6319819, Length=405, Percent_Identity=41.4814814814815, Blast_Score=292, Evalue=9e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47447; Mature: 47447

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIYEEFKGALSKIKVLRENANIIEETVQRSVREIIRNVREGKDEALSFYTKKFDGVEM
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
KDFRVSEEEIQQASMFVENSFLEALKEAKKNIVSYHEKQKKHSIFDCESKGIIRGQLIRP
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPRKGGIDPHILAAANLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHCCCCCHH
IYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVVA
HHCCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITMNMELAKEVEKEVERQLETLPRSEIARESIN
ECCCCCEEHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
RNGAIFIVPSLEEALKLSNEIAPEHLELHIKEPMNALDYVKHAGSIFLGPYSPEPLGDYL
CCCCEEEECCHHHHHHHHHCCCCCHHEEEECCCCHHHHHHHHCCCEEECCCCCCCCHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFISYTEEALKNVQHHIVELANKEGLHAHARA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IQIRFEEEK
EEEEEECCC
>Mature Secondary Structure
MEIIYEEFKGALSKIKVLRENANIIEETVQRSVREIIRNVREGKDEALSFYTKKFDGVEM
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
KDFRVSEEEIQQASMFVENSFLEALKEAKKNIVSYHEKQKKHSIFDCESKGIIRGQLIRP
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LENVGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPRKGGIDPHILAAANLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHCCCCCHH
IYTIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVVA
HHCCCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITMNMELAKEVEKEVERQLETLPRSEIARESIN
ECCCCCEEHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
RNGAIFIVPSLEEALKLSNEIAPEHLELHIKEPMNALDYVKHAGSIFLGPYSPEPLGDYL
CCCCEEEECCHHHHHHHHHCCCCCHHEEEECCCCHHHHHHHHCCCEEECCCCCCCCHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFISYTEEALKNVQHHIVELANKEGLHAHARA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IQIRFEEEK
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]