Click here to switch to the map view.

The map label for this gene is hisB [H]

Identifier: 218235800

GI number: 218235800

Start: 1402813

End: 1403397

Strand: Direct

Name: hisB [H]

Synonym: BCB4264_A1460

Alternate gene names: 218235800

Gene position: 1402813-1403397 (Clockwise)

Preceding gene: 218234866

Following gene: 218233723

Centisome position: 25.89

GC content: 37.61

Gene sequence:

>585_bases
ATGCGTCAGTCCAGTCAAGTACGTGAGACGAAAGAAACAAAAATTAAATTAAATTTGCAGCTTGATGAAAGTACAAATGT
ATCTATTCAAACAGGGGTTGGTTTTTTCGATCATATGCTTACTTTATTTGCTAGACATGGAAGATTTGGATTGCAGGTTG
AAGCAGAAGGTGATGTATTTGTCGATGCACATCACACCGTTGAAGATGTTGGAATTGTACTCGGAAATTGCTTGAAAGAA
GCATTGCAAAACAAAGAGGGAATTAATCGTTACGGTTCTGCGTATGTACCGATGGATGAATCTTTAGGATTTGTCGCAAT
TGATATAAGTGGACGCTCATATTGTGTATTTCAAGGGGAATTAACAAATCCGAAGCTTGGGGATTTTGATACAGAATTGA
CGGAAGAATTTTTTAGAGCAGTTGCACATGCTGCCAATATTACATTACATGCGCGCGTTCTATACGGAAGTAATACGCAT
CACAAAATTGAAGCATTATTTAAAGCTTTTGGTAGAGCGCTTAGAGAAGCGGTCGAAAAAAATGCCAACATTACTGGTGT
AAATTCAACGAAAGGGATGTTGTAA

Upstream 100 bases:

>100_bases
CATTAAAAAATGTACAGCATCATATTGTAGAGCTTGCAAATAAAGAAGGGTTACATGCACATGCGAGAGCAATCCAAATA
AGGTTTGAGGAGGAAAAATA

Downstream 100 bases:

>100_bases
TTGATTGCCATTATAGATTATGGAATGGGGAATATTCGCAGTGTAGAGCAAGCATTAAAATATATTGGCGCAGAGTACAT
TGTAACGAGTAATAAAAAAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRQSSQVRETKETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTH
HKIEALFKAFGRALREAVEKNANITGVNSTKGML

Sequences:

>Translated_194_residues
MRQSSQVRETKETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTH
HKIEALFKAFGRALREAVEKNANITGVNSTKGML
>Mature_194_residues
MRQSSQVRETKETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTH
HKIEALFKAFGRALREAVEKNANITGVNSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=46.1139896373057, Blast_Score=179, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=175, Percent_Identity=42.8571428571429, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21491; Mature: 21491

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSSQVRETKETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCCHHHHHCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGE
EECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTHHKIEALFKAFGRALREAVEK
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NANITGVNSTKGML
CCCEEECCCCCCCC
>Mature Secondary Structure
MRQSSQVRETKETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCCHHHHHCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGE
EECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTHHKIEALFKAFGRALREAVEK
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NANITGVNSTKGML
CCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA