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The map label for this gene is hisG [H]

Identifier: 218234195

GI number: 218234195

Start: 1400877

End: 1401512

Strand: Direct

Name: hisG [H]

Synonym: BCB4264_A1458

Alternate gene names: 218234195

Gene position: 1400877-1401512 (Clockwise)

Preceding gene: 218233691

Following gene: 218234866

Centisome position: 25.85

GC content: 33.81

Gene sequence:

>636_bases
ATGCGTAACATTCAAATTGCGTTAACGAAAGGAAGATTAGAAAAACATGTCATTCCACTTTTTGAGCAGATTGGAATTGA
TTGTTCCGAGCTCAAAAATAAAGGTCGGAAGCTTGTATTTCAAAGTAAAAATACAAATGTTTCATTTATTTTAGTAAAAG
CGATTGATGTTGCTACTTATGTAGAACATGGGGTAGCTGATATTGGCATCGTTGGAAAAGATATTTTAATGGAAAACGAG
AAAGATATTTATGAAATGCTGGATTTAGGAGTGGGGATTTGTAAGTTTTGTGTTGCTTCTATTCCTACGTATAATCCGAA
GAGTTACCGGAAGAAAAGAATCGCTACGAAATACCCCCATATTACTTCTACTTATTATCATGAAAAGGGAGAGGATGTAG
AAATTATTAAGATAGAAGGTTCTGTAGAAATCGCTCCTCTTCTTGGATTGGCAGATGCGATTGTAGATATTGTTGAAACA
GGAAAAACATTACAAGAGAATGGACTCATTGTATTTGAGGAAATGTACTTTATATCGGCTCGGATGATTGTAAATAAGGC
AGCCTTAAAAACTAAAAAAGACGAAATATTCAGCATTATAAATATGATGGAGCAAGAAATCTTATCAGGGAAATAG

Upstream 100 bases:

>100_bases
GAAAAAATAAAATAGGAACGGTCGTTGAGGCAAAGAATGAATACTTAGTGGAATATGTATGGAATGAGAAATGGGTAGTC
CAGAAAGAAGGAGAGGCTTC

Downstream 100 bases:

>100_bases
GAGGATTTAAAATGGAAATCATTTATGAAGAATTTAAGGGGGCATTATCTAAAATAAAAGTGCTAAGAGAAAACGCTAAT
ATAATAGAAGAAACTGTTCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTNVSFILVKAIDVATYVEHGVADIGIVGKDILMENE
KDIYEMLDLGVGICKFCVASIPTYNPKSYRKKRIATKYPHITSTYYHEKGEDVEIIKIEGSVEIAPLLGLADAIVDIVET
GKTLQENGLIVFEEMYFISARMIVNKAALKTKKDEIFSIINMMEQEILSGK

Sequences:

>Translated_211_residues
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTNVSFILVKAIDVATYVEHGVADIGIVGKDILMENE
KDIYEMLDLGVGICKFCVASIPTYNPKSYRKKRIATKYPHITSTYYHEKGEDVEIIKIEGSVEIAPLLGLADAIVDIVET
GKTLQENGLIVFEEMYFISARMIVNKAALKTKKDEIFSIINMMEQEILSGK
>Mature_211_residues
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTNVSFILVKAIDVATYVEHGVADIGIVGKDILMENE
KDIYEMLDLGVGICKFCVASIPTYNPKSYRKKRIATKYPHITSTYYHEKGEDVEIIKIEGSVEIAPLLGLADAIVDIVET
GKTLQENGLIVFEEMYFISARMIVNKAALKTKKDEIFSIINMMEQEILSGK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=208, Percent_Identity=31.25, Blast_Score=98, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=205, Percent_Identity=30.7317073170732, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23743; Mature: 23743

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTNVSFILVKAIDVATY
CCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCEEEEEEEHHHHHHH
VEHGVADIGIVGKDILMENEKDIYEMLDLGVGICKFCVASIPTYNPKSYRKKRIATKYPH
HHHCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ITSTYYHEKGEDVEIIKIEGSVEIAPLLGLADAIVDIVETGKTLQENGLIVFEEMYFISA
CCCCEECCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHCCEEEEEHHHHHHH
RMIVNKAALKTKKDEIFSIINMMEQEILSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTNVSFILVKAIDVATY
CCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCEEEEEEEHHHHHHH
VEHGVADIGIVGKDILMENEKDIYEMLDLGVGICKFCVASIPTYNPKSYRKKRIATKYPH
HHHCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ITSTYYHEKGEDVEIIKIEGSVEIAPLLGLADAIVDIVETGKTLQENGLIVFEEMYFISA
CCCCEECCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHCCEEEEEHHHHHHH
RMIVNKAALKTKKDEIFSIINMMEQEILSGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA