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The map label for this gene is yclK [H]

Identifier: 218233652

GI number: 218233652

Start: 2760185

End: 2761561

Strand: Reverse

Name: yclK [H]

Synonym: BCB4264_A2876

Alternate gene names: 218233652

Gene position: 2761561-2760185 (Counterclockwise)

Preceding gene: 218235082

Following gene: 218234193

Centisome position: 50.96

GC content: 30.07

Gene sequence:

>1377_bases
GTGAATAAACTTGGGAAAAAGCTATTTCTCAGCATTTCTTTAACCGTTATTCTTATATTTACAATTTCTTTATTATTAAT
TAACTTTCTCCTGCCGAAATATAATATTTATAAAACACGTGAAAACTTAAATAAATTTACAACTCAAATACAAAATGCGC
CAATCAATGATTTAGAAGATGTTATTCATACAATTGAAAGTGAAAATAACGTTACAATTGCGTATACGCCAATTAATCAG
TCGGAAGATGCTATGAACGACGCGTTACGCATGCAACTTACGAAAAAGAAAGTAACGTTAAATAAGCTTTGGATTACGAA
AGACGAAGTTATGAAAGTGAAGGCGGAAGGGCAATCGAATAAACTGTACGATCAAGGAAAGGTAAAAGCGAGTTTTTTTG
CTAAATATATTGCGAAAGATGATACGATAATTTTAATTGGGACTTCCATTGCGAATTCAAATGAAATTATAAATACGTTA
AATACATTTTACTTATATATCCTATGTTTCTCGCTCCTTCTTATTATTTTACTTGTGTGGATACTTTCAAAAATAATAAC
GAAACCACTGAAAGAGTTAAGTGATGTGGCTCAGGATATTTCACATTTGCAGTTTAAAAGAACGAAAGTGAAAACGAATG
ATGAAATAGGAGAGTTGGCCAATAGTATTAATATCATGAGTGAAAAACTACATGAAGCACATCAAGACTTAACTGATCGT
AATGAACATTTAAAACGATTTATGGGTGATGTAACGCATGAATTAAAGACACCGATCGCATTAGTAAAAGCATACTCTAT
GGGGATTAAAGATGGATTAGATGATGGGACTTATGTAGATACAATTATTAAACAAACAGATCAAATATCAAACTTAATTG
AAGAACTATTACGATTTTCTAAACTAGAAAGAGATATTTTACAAAAAGAAGAATTCCCCATTGAACCACTGGTTCAGAGT
ATATTAGATAAGCATCAGATTGAACTGGATTCGAAAGAAATTAACTTGCAAGTAAATTGTAATGCGGGCGATACAATCGT
TTATGCAGATTTAAATAAAATGAGAATGGTGTTTCAAAATTTAATTTCTAATGCGATAAAATATACAGCAAATCAAAACA
TAATAATTACATTAGAAGATAGAAATAAAAGTATATATTTCCAAATAAAAAATGGCATTCCTACGGATAAAATTAAGGAT
ATCGAGAAAATTTGGGAGCCTTTTTATGTACTAGAATCTTCTCGTAGTAAAGAAAAATCAGGTACAGGATTAGGTTTAGC
GATAGTGAAAAGTATTTTAGAAAGGCATGGTTTTGAATATGGAGTTTCCTCTATAGATGGAGAAATTCAATTTTATATAA
ATGTGAAAAAGGACTAA

Upstream 100 bases:

>100_bases
GAGAGAACGGTTGATACACATGTAAGAAGGCTACGTAAAAAAATTGGAGAAAATATTATTAAGACGCATCGTGGGCTGGG
TTATAGTTTGGAGGAACAAA

Downstream 100 bases:

>100_bases
TGAAAATATTAGTCCTTTTTGCAGCTTTAGAGATTAGCGATACAGGATGAATCACTATAATTTTCAAAATTGATGTATTA
AATGGAGAATTAGCAAATGT

Product: putative sensor histidine kinase SrrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNKLGKKLFLSISLTVILIFTISLLLINFLLPKYNIYKTRENLNKFTTQIQNAPINDLEDVIHTIESENNVTIAYTPINQ
SEDAMNDALRMQLTKKKVTLNKLWITKDEVMKVKAEGQSNKLYDQGKVKASFFAKYIAKDDTIILIGTSIANSNEIINTL
NTFYLYILCFSLLLIILLVWILSKIITKPLKELSDVAQDISHLQFKRTKVKTNDEIGELANSINIMSEKLHEAHQDLTDR
NEHLKRFMGDVTHELKTPIALVKAYSMGIKDGLDDGTYVDTIIKQTDQISNLIEELLRFSKLERDILQKEEFPIEPLVQS
ILDKHQIELDSKEINLQVNCNAGDTIVYADLNKMRMVFQNLISNAIKYTANQNIIITLEDRNKSIYFQIKNGIPTDKIKD
IEKIWEPFYVLESSRSKEKSGTGLGLAIVKSILERHGFEYGVSSIDGEIQFYINVKKD

Sequences:

>Translated_458_residues
MNKLGKKLFLSISLTVILIFTISLLLINFLLPKYNIYKTRENLNKFTTQIQNAPINDLEDVIHTIESENNVTIAYTPINQ
SEDAMNDALRMQLTKKKVTLNKLWITKDEVMKVKAEGQSNKLYDQGKVKASFFAKYIAKDDTIILIGTSIANSNEIINTL
NTFYLYILCFSLLLIILLVWILSKIITKPLKELSDVAQDISHLQFKRTKVKTNDEIGELANSINIMSEKLHEAHQDLTDR
NEHLKRFMGDVTHELKTPIALVKAYSMGIKDGLDDGTYVDTIIKQTDQISNLIEELLRFSKLERDILQKEEFPIEPLVQS
ILDKHQIELDSKEINLQVNCNAGDTIVYADLNKMRMVFQNLISNAIKYTANQNIIITLEDRNKSIYFQIKNGIPTDKIKD
IEKIWEPFYVLESSRSKEKSGTGLGLAIVKSILERHGFEYGVSSIDGEIQFYINVKKD
>Mature_458_residues
MNKLGKKLFLSISLTVILIFTISLLLINFLLPKYNIYKTRENLNKFTTQIQNAPINDLEDVIHTIESENNVTIAYTPINQ
SEDAMNDALRMQLTKKKVTLNKLWITKDEVMKVKAEGQSNKLYDQGKVKASFFAKYIAKDDTIILIGTSIANSNEIINTL
NTFYLYILCFSLLLIILLVWILSKIITKPLKELSDVAQDISHLQFKRTKVKTNDEIGELANSINIMSEKLHEAHQDLTDR
NEHLKRFMGDVTHELKTPIALVKAYSMGIKDGLDDGTYVDTIIKQTDQISNLIEELLRFSKLERDILQKEEFPIEPLVQS
ILDKHQIELDSKEINLQVNCNAGDTIVYADLNKMRMVFQNLISNAIKYTANQNIIITLEDRNKSIYFQIKNGIPTDKIKD
IEKIWEPFYVLESSRSKEKSGTGLGLAIVKSILERHGFEYGVSSIDGEIQFYINVKKD

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=27.34375, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788279, Length=278, Percent_Identity=27.3381294964029, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=193, Percent_Identity=25.3886010362694, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789149, Length=334, Percent_Identity=24.5508982035928, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=211, Percent_Identity=24.6445497630332, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=190, Percent_Identity=30, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=23.7458193979933, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=26.056338028169, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=25.6521739130435, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=25.5506607929515, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=26.6949152542373, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=274, Percent_Identity=23.3576642335766, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=22.0640569395018, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=295, Percent_Identity=25.0847457627119, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=22.8346456692913, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52460; Mature: 52460

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLGKKLFLSISLTVILIFTISLLLINFLLPKYNIYKTRENLNKFTTQIQNAPINDLED
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
VIHTIESENNVTIAYTPINQSEDAMNDALRMQLTKKKVTLNKLWITKDEVMKVKAEGQSN
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEHHHEEECHHHHHEEECCCCCC
KLYDQGKVKASFFAKYIAKDDTIILIGTSIANSNEIINTLNTFYLYILCFSLLLIILLVW
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSKIITKPLKELSDVAQDISHLQFKRTKVKTNDEIGELANSINIMSEKLHEAHQDLTDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
NEHLKRFMGDVTHELKTPIALVKAYSMGIKDGLDDGTYVDTIIKQTDQISNLIEELLRFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLERDILQKEEFPIEPLVQSILDKHQIELDSKEINLQVNCNAGDTIVYADLNKMRMVFQN
HHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCEEEEEEECCCCCEEEEECHHHHHHHHHH
LISNAIKYTANQNIIITLEDRNKSIYFQIKNGIPTDKIKDIEKIWEPFYVLESSRSKEKS
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCHHHHHHCCCCCCCC
GTGLGLAIVKSILERHGFEYGVSSIDGEIQFYINVKKD
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MNKLGKKLFLSISLTVILIFTISLLLINFLLPKYNIYKTRENLNKFTTQIQNAPINDLED
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
VIHTIESENNVTIAYTPINQSEDAMNDALRMQLTKKKVTLNKLWITKDEVMKVKAEGQSN
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEHHHEEECHHHHHEEECCCCCC
KLYDQGKVKASFFAKYIAKDDTIILIGTSIANSNEIINTLNTFYLYILCFSLLLIILLVW
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSKIITKPLKELSDVAQDISHLQFKRTKVKTNDEIGELANSINIMSEKLHEAHQDLTDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
NEHLKRFMGDVTHELKTPIALVKAYSMGIKDGLDDGTYVDTIIKQTDQISNLIEELLRFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLERDILQKEEFPIEPLVQSILDKHQIELDSKEINLQVNCNAGDTIVYADLNKMRMVFQN
HHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCEEEEEEECCCCCEEEEECHHHHHHHHHH
LISNAIKYTANQNIIITLEDRNKSIYFQIKNGIPTDKIKDIEKIWEPFYVLESSRSKEKS
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCHHHHHHCCCCCCCC
GTGLGLAIVKSILERHGFEYGVSSIDGEIQFYINVKKD
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]