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The map label for this gene is prsA [H]

Identifier: 218234193

GI number: 218234193

Start: 2759153

End: 2759995

Strand: Reverse

Name: prsA [H]

Synonym: BCB4264_A2875

Alternate gene names: 218234193

Gene position: 2759995-2759153 (Counterclockwise)

Preceding gene: 218233652

Following gene: 218232720

Centisome position: 50.93

GC content: 30.72

Gene sequence:

>843_bases
TTGAAAAGAAAGAAATTAGTAATTGGTAGCATTTTAATGGGTATGACGTTATCTTTATCTGCATGTGGTTCATCAGATAA
TATTGTAACGACAAAATCAGGAAGCATTTCAGAAAGTGATTTTAACAAAAAATTAAAAGAAAACTACGGTAAACAGAATT
TATCTGAAATGGTAGTAGAAAAAGTATTACATGATAAATATAAAGTTACGGATGAAGAGGTAACGAAACAACTAAAAGAA
TTAAAAGACAAGATGGGCGATAATTTTAATACATATATGGAATCCAATGGTGTGAAAAATGAAGATCAGTTGAAAGAGAA
ATTAAAGCTTACTTTTGCTTTTGAAAAAGCTATTAAAGCAACCGTAACGGAAAAAGATATTAAAGATCATTATAAGCCAA
AGCTTCAAGTTAGCCATATTTTAGTAAAAGATGAAAAGACAGCAAAAGAAATTAAAGAAAAATTAAATAGTGGCGAAGAT
TTCGCGGCATTGGCTAAACAATATTCAGAGGATCCAGGTTCTAAAGAAAAAGGTGGGGAACTATCTGAATTTGGACCTGG
TATGATGGTGAAAGAATTTGAGGATGCTGCGTATAAGTTAGAAGTTGGTCAATTGAGTGAACCTGTTAAATCTTCTTTCG
GATATCATATTATTAAGCTAATGGATAAAAAAGAGCTTAAACCGTATGAGGAAGAGAAAGAGAATATTCGTAAAGAATTA
GAACAGCAACGTATACAAGATCCTCAATTCCATCAACAAGTTACTAGAGAACTGCTTAAAAATGCAGATATAAAGGTATC
TGATAAAGACTTGAAAGATACCTTTAAAGAGTTAGAAAAATAA

Upstream 100 bases:

>100_bases
TTAGCAAATGTTCTACTTTCATTAAATTCACGTGAAGTTCACAGGAAAACGTTATATTTACATAGTTATATTTGAATTTA
ATGAAGTGAGGTATTCAGAT

Downstream 100 bases:

>100_bases
TAAATGGAATGTAAGGCAAGCGATAGAAATATCGGTTGTCTTTTTCTCTATTTATCCCGCTATTTGCCGGGCAGTAAGAT
CCCACCTCAAAATTCAGCGA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKRKKLVIGSILMGMTLSLSACGSSDNIVTTKSGSISESDFNKKLKENYGKQNLSEMVVEKVLHDKYKVTDEEVTKQLKE
LKDKMGDNFNTYMESNGVKNEDQLKEKLKLTFAFEKAIKATVTEKDIKDHYKPKLQVSHILVKDEKTAKEIKEKLNSGED
FAALAKQYSEDPGSKEKGGELSEFGPGMMVKEFEDAAYKLEVGQLSEPVKSSFGYHIIKLMDKKELKPYEEEKENIRKEL
EQQRIQDPQFHQQVTRELLKNADIKVSDKDLKDTFKELEK

Sequences:

>Translated_280_residues
MKRKKLVIGSILMGMTLSLSACGSSDNIVTTKSGSISESDFNKKLKENYGKQNLSEMVVEKVLHDKYKVTDEEVTKQLKE
LKDKMGDNFNTYMESNGVKNEDQLKEKLKLTFAFEKAIKATVTEKDIKDHYKPKLQVSHILVKDEKTAKEIKEKLNSGED
FAALAKQYSEDPGSKEKGGELSEFGPGMMVKEFEDAAYKLEVGQLSEPVKSSFGYHIIKLMDKKELKPYEEEKENIRKEL
EQQRIQDPQFHQQVTRELLKNADIKVSDKDLKDTFKELEK
>Mature_280_residues
MKRKKLVIGSILMGMTLSLSACGSSDNIVTTKSGSISESDFNKKLKENYGKQNLSEMVVEKVLHDKYKVTDEEVTKQLKE
LKDKMGDNFNTYMESNGVKNEDQLKEKLKLTFAFEKAIKATVTEKDIKDHYKPKLQVSHILVKDEKTAKEIKEKLNSGED
FAALAKQYSEDPGSKEKGGELSEFGPGMMVKEFEDAAYKLEVGQLSEPVKSSFGYHIIKLMDKKELKPYEEEKENIRKEL
EQQRIQDPQFHQQVTRELLKNADIKVSDKDLKDTFKELEK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786238, Length=86, Percent_Identity=45.3488372093023, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=43.3734939759036, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786645, Length=197, Percent_Identity=29.9492385786802, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32086; Mature: 32086

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKKLVIGSILMGMTLSLSACGSSDNIVTTKSGSISESDFNKKLKENYGKQNLSEMVVE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHH
KVLHDKYKVTDEEVTKQLKELKDKMGDNFNTYMESNGVKNEDQLKEKLKLTFAFEKAIKA
HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TVTEKDIKDHYKPKLQVSHILVKDEKTAKEIKEKLNSGEDFAALAKQYSEDPGSKEKGGE
HHHHHHHHHHCCCCHHHHHHEECCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
LSEFGPGMMVKEFEDAAYKLEVGQLSEPVKSSFGYHIIKLMDKKELKPYEEEKENIRKEL
HHHHCCCCHHHHHHHHHHEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHH
EQQRIQDPQFHQQVTRELLKNADIKVSDKDLKDTFKELEK
HHHHCCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHCC
>Mature Secondary Structure
MKRKKLVIGSILMGMTLSLSACGSSDNIVTTKSGSISESDFNKKLKENYGKQNLSEMVVE
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHH
KVLHDKYKVTDEEVTKQLKELKDKMGDNFNTYMESNGVKNEDQLKEKLKLTFAFEKAIKA
HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TVTEKDIKDHYKPKLQVSHILVKDEKTAKEIKEKLNSGEDFAALAKQYSEDPGSKEKGGE
HHHHHHHHHHCCCCHHHHHHEECCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
LSEFGPGMMVKEFEDAAYKLEVGQLSEPVKSSFGYHIIKLMDKKELKPYEEEKENIRKEL
HHHHCCCCHHHHHHHHHHEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHH
EQQRIQDPQFHQQVTRELLKNADIKVSDKDLKDTFKELEK
HHHHCCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]