Click here to switch to the map view.

The map label for this gene is yisK [H]

Identifier: 218233588

GI number: 218233588

Start: 225131

End: 226087

Strand: Direct

Name: yisK [H]

Synonym: BCB4264_A0256

Alternate gene names: 218233588

Gene position: 225131-226087 (Clockwise)

Preceding gene: 218234156

Following gene: 218231675

Centisome position: 4.15

GC content: 37.62

Gene sequence:

>957_bases
ATGAAATTTGTTACATTTCGTCTTCCTTCAAAAGAACTACGGGCTGGATGGCTTGAAGGTGACAAAGTAATAGATATGAA
TCTTGCTAGTGAAGGGAAAATCCCTTCTTCTATGATTGCTTTTTTAGAGAAAGCGGATGAGTATGTAGAAGTAGTGCGGA
ATATTAAGAATCCAAATAAGGGTATATATGCTTTAGAAGAAGTACAATTGACAGCTGCTCTTCCTAATCCGAGTAGTATT
CGAGATTTTTACGCATTTGAACAACATGTAAAAACAGCTCGCGGACGAAGAGGATTAGATGTTGTGCCTGAATGGTATGA
TATTCCGGTTTTTTATTTTACTAATCATCGTGCTGTAATTGGTTCCAGTGATTTTGTAATTGGTCCGAAAAAGTCTAAAA
AGCTTGATTATGAGTTGGAGATTGCTTGCGTAATAGGAAGAGAAGGGCGAAATATTTCTCGTGAGCAAGCAGAGGAATAT
ATTTTTGGTTATTGTATTATGAACGACTGGAGTGCGAGAGACTTACAAGCAACAGAAATGAAAGTAGGTCTCGGTCCAGC
GAAAGGAAAAGACTTTGCAACTTCTTTAGGAGCACATCTTGTTACGAAAGAGGAATTAGACGTTTATCGTAATGGTGATC
GATATAATTTAGAAATGACTGCTCATGTAAATGGAAAACTATTATCAAAAGGAAACTTCCAAGATATTTACTATACATTT
GCTGAAATGATTGAACGTGCTTCAGAGGACGTTACGTTATATCCAGGAGATGTGATTGGTTCTGGGACAGTAGGAACAGG
ATGTATTTTAGAACTGGGTACAGAAGAGTGGCTACAAGATGGAGATGTTGTAGAACTGTCGATTACTGGTTTAGGTACAC
TACGTAATATGATCAAAAAAGAAAAGGAAGCGGGTGATGGGCATGTTTTATCGTCACATGGGAGAACTACCTCATAA

Upstream 100 bases:

>100_bases
TGAAAGAGAACAAGAGCGTCGCGGAAACTTATAAGATTTGTATCCACCAGCAAAAGTCCCTTTGCTGGTGGAAATTTCAT
TTTTATAAGGAGGAATCAGG

Downstream 100 bases:

>100_bases
ACGACATGTACAATTTCGTAAAAAAGATGGATCGCTTTATCGTGAACAGGTAATGGGAACAAAAGGTTTTTCTGGTACGC
AGTCTATTTTGTATCATCAT

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKFVTFRLPSKELRAGWLEGDKVIDMNLASEGKIPSSMIAFLEKADEYVEVVRNIKNPNKGIYALEEVQLTAALPNPSSI
RDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVIGSSDFVIGPKKSKKLDYELEIACVIGREGRNISREQAEEY
IFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAHLVTKEELDVYRNGDRYNLEMTAHVNGKLLSKGNFQDIYYTF
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELSITGLGTLRNMIKKEKEAGDGHVLSSHGRTTS

Sequences:

>Translated_318_residues
MKFVTFRLPSKELRAGWLEGDKVIDMNLASEGKIPSSMIAFLEKADEYVEVVRNIKNPNKGIYALEEVQLTAALPNPSSI
RDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVIGSSDFVIGPKKSKKLDYELEIACVIGREGRNISREQAEEY
IFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAHLVTKEELDVYRNGDRYNLEMTAHVNGKLLSKGNFQDIYYTF
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELSITGLGTLRNMIKKEKEAGDGHVLSSHGRTTS
>Mature_318_residues
MKFVTFRLPSKELRAGWLEGDKVIDMNLASEGKIPSSMIAFLEKADEYVEVVRNIKNPNKGIYALEEVQLTAALPNPSSI
RDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVIGSSDFVIGPKKSKKLDYELEIACVIGREGRNISREQAEEY
IFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAHLVTKEELDVYRNGDRYNLEMTAHVNGKLLSKGNFQDIYYTF
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELSITGLGTLRNMIKKEKEAGDGHVLSSHGRTTS

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=310, Percent_Identity=29.0322580645161, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI40786394, Length=307, Percent_Identity=28.9902280130293, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557587, Length=289, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI13654274, Length=194, Percent_Identity=27.319587628866, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI215422413, Length=185, Percent_Identity=28.1081081081081, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI66348062, Length=185, Percent_Identity=28.1081081081081, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568863, Length=270, Percent_Identity=29.6296296296296, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28572127, Length=190, Percent_Identity=36.8421052631579, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24657182, Length=274, Percent_Identity=29.1970802919708, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24663695, Length=213, Percent_Identity=27.2300469483568, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571789, Length=197, Percent_Identity=24.8730964467005, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 35510; Mature: 35510

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVTFRLPSKELRAGWLEGDKVIDMNLASEGKIPSSMIAFLEKADEYVEVVRNIKNPNK
CCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GIYALEEVQLTAALPNPSSIRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVI
CEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCEEEE
GSSDFVIGPKKSKKLDYELEIACVIGREGRNISREQAEEYIFGYCIMNDWSARDLQATEM
CCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCEEEEE
KVGLGPAKGKDFATSLGAHLVTKEELDVYRNGDRYNLEMTAHVNGKLLSKGNFQDIYYTF
EECCCCCCCCHHHHHHHHHHEEHHHHHHEECCCEEEEEEEEEECCEEECCCCCHHHHHHH
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELSITGLGTLRNMIKK
HHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHCCCCEEEEEECCHHHHHHHHHH
EKEAGDGHVLSSHGRTTS
HHCCCCCCEEECCCCCCC
>Mature Secondary Structure
MKFVTFRLPSKELRAGWLEGDKVIDMNLASEGKIPSSMIAFLEKADEYVEVVRNIKNPNK
CCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GIYALEEVQLTAALPNPSSIRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVI
CEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCEEEE
GSSDFVIGPKKSKKLDYELEIACVIGREGRNISREQAEEYIFGYCIMNDWSARDLQATEM
CCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCEEEEE
KVGLGPAKGKDFATSLGAHLVTKEELDVYRNGDRYNLEMTAHVNGKLLSKGNFQDIYYTF
EECCCCCCCCHHHHHHHHHHEEHHHHHHEECCCEEEEEEEEEECCEEECCCCCHHHHHHH
AEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELSITGLGTLRNMIKK
HHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHCCCCEEEEEECCHHHHHHHHHH
EKEAGDGHVLSSHGRTTS
HHCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]