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The map label for this gene is hppD [H]

Identifier: 218234156

GI number: 218234156

Start: 223946

End: 225064

Strand: Direct

Name: hppD [H]

Synonym: BCB4264_A0255

Alternate gene names: 218234156

Gene position: 223946-225064 (Clockwise)

Preceding gene: 218233582

Following gene: 218233588

Centisome position: 4.13

GC content: 36.46

Gene sequence:

>1119_bases
ATGAAACAAAAATCTATGGATACGCTAGCTGCACAAATGGAGGACTTTTTTCCAGTACGTGATGTAGATCATTTGGAATT
TTACGTAGGGAATGCAAAGCAATCGAGTTATTATCTTGCGAGAGCGTTCGGATTCAAAATTGTGGCTTACTCTGGATTAG
AAACTGGAAACCGTGAAAAGGTATCTTATGTTCTTGTGCAAAAAAATATGCGTTTCGTTGTGTCTGGAGCTTTAAGTAGT
GAAAATCGTATTGCAGAGTTTGTAAAGACTCATGGTGATGGCGTGAAGGATGTGGCACTACTTGTTGATGATGTTGATAA
AGCATACTCAGAAGCAGTGAAACGTGGTGCCGTCGCAATTGCTCCACCGCAGGAATTAACAGATGAGGACGGTACATTGA
AAAAAGCAGTTATTGGTACGTATGGTGATACAATTCATACGCTTGTAGAGCGTAAAAATTATAAAGGGGCATTTATGCCA
GGATTCCAAAAGGTAGAATTTAATATTCCATTTGAAGAGTCTGGTTTAATTGCTGTTGATCATGTAGTTGGTAATGTTGA
AAAAATGGAAGAGTGGGTTAGTTATTACGAGAATGTTATGGGCTTTAAACAAATGATTCATTTTGATGATGACGATATTA
GTACAGAGTATTCGGCGTTAATGTCGAAAGTTATGACAAATGGAAGTCGTATTAAGTTTCCTATTAACGAACCAGCAGAT
GGAAAGAGAAAGTCACAAATTCAAGAGTATCTAGAATTCTATAATGGAGCTGGTGTACAACATCTTGCTTTATTAACAAG
TGATATTGTTAAAACAGTTGAAGCGCTTCGTGCAAATGGGGTGGAGTTTTTAGATACACCTGATACTTATTATGATGAGT
TAACTGCACGAGTTGGAAAAATCGATGAAGAAATTGATAAGTTAAAAGAATTAAAGATCTTAGTAGATCGTGATGATGAA
GGTTACTTACTACAAATCTTTACGAAACCAATTGTAGATCGCCCGACTTTATTTATTGAAATCATTCAACGTAAAGGTTC
TCGTGGATTTGGTGAAGGAAACTTTAAAGCGTTATTCGAATCAATTGAAAGAGAACAAGAGCGTCGCGGAAACTTATAA

Upstream 100 bases:

>100_bases
GTTAGCTTGCTAACTAATTTCTATTAATTAATGTTGGAAGCGTTTTCGGTTGGTTTTAAGTATGGACCATTTAATCTATT
TACAGGGGGATGAAGATATT

Downstream 100 bases:

>100_bases
GATTTGTATCCACCAGCAAAAGTCCCTTTGCTGGTGGAAATTTCATTTTTATAAGGAGGAATCAGGATGAAATTTGTTAC
ATTTCGTCTTCCTTCAAAAG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALSS
ENRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPQELTDEDGTLKKAVIGTYGDTIHTLVERKNYKGAFMP
GFQKVEFNIPFEESGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
GKRKSQIQEYLEFYNGAGVQHLALLTSDIVKTVEALRANGVEFLDTPDTYYDELTARVGKIDEEIDKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL

Sequences:

>Translated_372_residues
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALSS
ENRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPQELTDEDGTLKKAVIGTYGDTIHTLVERKNYKGAFMP
GFQKVEFNIPFEESGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
GKRKSQIQEYLEFYNGAGVQHLALLTSDIVKTVEALRANGVEFLDTPDTYYDELTARVGKIDEEIDKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL
>Mature_372_residues
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALSS
ENRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPQELTDEDGTLKKAVIGTYGDTIHTLVERKNYKGAFMP
GFQKVEFNIPFEESGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
GKRKSQIQEYLEFYNGAGVQHLALLTSDIVKTVEALRANGVEFLDTPDTYYDELTARVGKIDEEIDKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=360, Percent_Identity=49.1666666666667, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI285002264, Length=344, Percent_Identity=49.4186046511628, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI14249394, Length=374, Percent_Identity=27.2727272727273, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17555220, Length=364, Percent_Identity=50, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17550752, Length=366, Percent_Identity=37.9781420765027, Blast_Score=244, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24667510, Length=361, Percent_Identity=48.4764542936288, Blast_Score=324, Evalue=5e-89,
Organism=Drosophila melanogaster, GI21356105, Length=292, Percent_Identity=51.027397260274, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 42093; Mature: 42093

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREK
CCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCHHHHHHHHCEEEEEECCCCCCCCCC
VSYVLVQKNMRFVVSGALSSENRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAI
EEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
APPQELTDEDGTLKKAVIGTYGDTIHTLVERKNYKGAFMPGFQKVEFNIPFEESGLIAVD
CCCHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEH
HVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCC
GKRKSQIQEYLEFYNGAGVQHLALLTSDIVKTVEALRANGVEFLDTPDTYYDELTARVGK
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
IDEEIDKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFE
HHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIEREQERRGNL
HHHHHHHHCCCC
>Mature Secondary Structure
MKQKSMDTLAAQMEDFFPVRDVDHLEFYVGNAKQSSYYLARAFGFKIVAYSGLETGNREK
CCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCHHHHHHHHCEEEEEECCCCCCCCCC
VSYVLVQKNMRFVVSGALSSENRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAI
EEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
APPQELTDEDGTLKKAVIGTYGDTIHTLVERKNYKGAFMPGFQKVEFNIPFEESGLIAVD
CCCHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEH
HVVGNVEKMEEWVSYYENVMGFKQMIHFDDDDISTEYSALMSKVMTNGSRIKFPINEPAD
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCC
GKRKSQIQEYLEFYNGAGVQHLALLTSDIVKTVEALRANGVEFLDTPDTYYDELTARVGK
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
IDEEIDKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFE
HHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIEREQERRGNL
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]