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The map label for this gene is 218231675

Identifier: 218231675

GI number: 218231675

Start: 226047

End: 227225

Strand: Direct

Name: 218231675

Synonym: BCB4264_A0257

Alternate gene names: NA

Gene position: 226047-227225 (Clockwise)

Preceding gene: 218233588

Following gene: 218232301

Centisome position: 4.17

GC content: 38.42

Gene sequence:

>1179_bases
ATGGGCATGTTTTATCGTCACATGGGAGAACTACCTCATAAACGACATGTACAATTTCGTAAAAAAGATGGATCGCTTTA
TCGTGAACAGGTAATGGGAACAAAAGGTTTTTCTGGTACGCAGTCTATTTTGTATCATCATTATATGCCGACAGAAGTAG
GTCATTCTGCATTATCGCATTCTTGTCAGTTGCAGTATGAAGAGGATGTTGCTCTTTCTCATCGCCACTTTCGAACGAAA
GAAAGTAAAAAAAGTGGTGATGCAATAAGTGGACGGAATTTCATACTTGGAAATGAAGATTTATTAATTGGAGTAGTGAG
TCCAACAGAAAAAATGGATTATTTCTATCGTAATGGTGATGGCGACGAAATGTTATTTGTTCATTATGGAACAGGGAAAA
TTGAAACGATGTTTGGAACGATTCACTATAGAAAAGGCGACTATGTAACGATTCCAATTGGAACAATTTATCGTGTTATT
CCAGATGAAGGAGAGACTAAGTTTCTTGTTGTAGAGGCGAATAGCCAAATTACAACGCCGCGTCGTTATCGAAATGAATA
CGGACAATTGTTAGAGCATAGTCCGTTTTGTGAAAGAGATCTTCGTGGTCCAGAAAAATTAGAGACATATGATGAAAAAG
GCGAGTTTGTCGTAATGACAAAATCAAGAGGCTATATGCATAAACATGTTTTAGGACACCACCCGTTAGATGTTGTGGGA
TGGGATGGCTATTTATATCCGTGGGTATTTAATGTAGAGGATTTTGAACCAATTACAGGGCGCATTCATCAGCCACCGCC
AGTACATCAAACATTTGAAGGACATAATTTTGTTATTTGCTCTTTCGTACCACGTTTATACGATTATCATCCAGAGTCAA
TTCCGGCACCATATTATCATAGTAATGTTAATAGTGATGAAGTTCTTTACTATGTAGAAGGAAACTTTATGAGTCGCAAA
GGTGTGGAAGAAGGTTCTATTACACTTCATCCGAGCGGGATTCCCCATGGGCCGCATCCGGGGAAAACAGAGGCAAGTAT
AGGGAAGAAAGAGACGCTTGAATTAGCTGTTATGATAGACACATTCCGTCCGCTTCGTATTGTAAAACAAGCACATGAAA
CAGAAGATGAAAAGTATATGTATAGCTGGATTGAACAAGGTTCATATACTGTGAAATAA

Upstream 100 bases:

>100_bases
GGTACAGAAGAGTGGCTACAAGATGGAGATGTTGTAGAACTGTCGATTACTGGTTTAGGTACACTACGTAATATGATCAA
AAAAGAAAAGGAAGCGGGTG

Downstream 100 bases:

>100_bases
GTGAAAAAAGGCATGCTCTCAATAAGGGGGCATGCCTTTTTCACGGAATCGACATGTATAATAATACCAAAAAAATAATG
GAAAGATATATAGAAAGAAT

Product: putative homogentisate 1,2-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MGMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHSALSHSCQLQYEEDVALSHRHFRTK
ESKKSGDAISGRNFILGNEDLLIGVVSPTEKMDYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVI
PDEGETKFLVVEANSQITTPRRYRNEYGQLLEHSPFCERDLRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVG
WDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSRK
GVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEQGSYTVK

Sequences:

>Translated_392_residues
MGMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHSALSHSCQLQYEEDVALSHRHFRTK
ESKKSGDAISGRNFILGNEDLLIGVVSPTEKMDYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVI
PDEGETKFLVVEANSQITTPRRYRNEYGQLLEHSPFCERDLRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVG
WDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSRK
GVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEQGSYTVK
>Mature_391_residues
GMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHSALSHSCQLQYEEDVALSHRHFRTKE
SKKSGDAISGRNFILGNEDLLIGVVSPTEKMDYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIP
DEGETKFLVVEANSQITTPRRYRNEYGQLLEHSPFCERDLRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVGW
DGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSRKG
VEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEQGSYTVK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 45293; Mature: 45162

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHSALSH
CCCHHHHHCCCCCHHCCEEECCCCHHHHHHHCCCCCCCCCHHHEEEECCCHHHHHHHHCC
SCQLQYEEDVALSHRHFRTKESKKSGDAISGRNFILGNEDLLIGVVSPTEKMDYFYRNGD
CEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHCCEEEECCC
GDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPDEGETKFLVVEANSQITTP
CCEEEEEEECCCEEEEEEEEEEEECCCEEEEEHHHEEEEECCCCCEEEEEEECCCCCCCC
RRYRNEYGQLLEHSPFCERDLRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVG
HHHHHHHHHHHHCCCCCHHHCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCEEEE
WDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYH
CCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCEE
SNVNSDEVLYYVEGNFMSRKGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMID
CCCCCCEEEEEEECCEECCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEE
TFRPLRIVKQAHETEDEKYMYSWIEQGSYTVK
CCCHHHHHHHHHCCCCHHHHHHHHHCCCEECC
>Mature Secondary Structure 
GMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHSALSH
CCHHHHHCCCCCHHCCEEECCCCHHHHHHHCCCCCCCCCHHHEEEECCCHHHHHHHHCC
SCQLQYEEDVALSHRHFRTKESKKSGDAISGRNFILGNEDLLIGVVSPTEKMDYFYRNGD
CEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHCCEEEECCC
GDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPDEGETKFLVVEANSQITTP
CCEEEEEEECCCEEEEEEEEEEEECCCEEEEEHHHEEEEECCCCCEEEEEEECCCCCCCC
RRYRNEYGQLLEHSPFCERDLRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVVG
HHHHHHHHHHHHCCCCCHHHCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCEEEE
WDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYH
CCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCEE
SNVNSDEVLYYVEGNFMSRKGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMID
CCCCCCEEEEEEECCEECCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEE
TFRPLRIVKQAHETEDEKYMYSWIEQGSYTVK
CCCHHHHHHHHHCCCCHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]