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The map label for this gene is capL [H]

Identifier: 218233449

GI number: 218233449

Start: 493329

End: 494570

Strand: Direct

Name: capL [H]

Synonym: BCB4264_A0509

Alternate gene names: 218233449

Gene position: 493329-494570 (Clockwise)

Preceding gene: 218234686

Following gene: 218232522

Centisome position: 9.1

GC content: 34.94

Gene sequence:

>1242_bases
ATGAATAGTAGTAAAGTAGCTATTATTGGGCTAGGGTATGTTGGCCTTCCTTTAGCGGTACATTTTGCAGAAAGAGGGCA
TACAGTACTTGGATTAGATAAAGATATTAGAAAAATAGACTCAATTATAAAAGGAGAAAGTTATATTCCGGATGTTTCTT
CTAAAGAGTTACAAAGTTTATTGACGAAAAAAAAATTAACAGTAAATACACCGGATCAAGGCATTGCTGATTTTCAAAAT
AGTGATTATGTTATTGTCACTGTCCCGACTCCAATTAATGAACAAAGAGAACCAGACTTAAGTGCCCTCATTTCAGCTTC
GCATTATATACAACAAAACCTTCAAAAAGGACAAACCTTCATTTTTGAAAGCTCCACATATCCAGGCACACTTGAAGAAG
TCATCCTACCTATTATTTCTCAAAATGGTAAAAAGGTAGGGGAAGATTTCTATATCGGATATTCCCCTGAGAGAATTGAT
CCAGCAAATAGTCAATATTCAGTTCAAGCTATTCCAAAAGTTATTAGTGGACAAACAGAAAAGTGTAGACAAAAGGTACA
GGATTTATATAGTACCATTTTTGACGAAGTTGTACCTGTTAGCTCTCCGAAAGTAGCAGAGATGTGCAAGCTATTTGAAA
ATATTCAGCGCTTAGTTAACATTTCTTTAGTAAATGAACTAAACACACTATGTGAAAGTTTAGGCATTGATTTTTATGAG
GCCATTGAAGCGGCATCTACAAAACCATTTGGGTTTACTCCGTATTGGCCAGGGCCAGGGATAGGGGGACACTGTATTCC
CGTAGACCCTTTATATTTTCAATGGAGAATAAAAAAGAATGGAGCAATTAGTCAATTAATTGAGGCTGCACATATAATTA
ATGAAGAAATGCCAGAGAAAATGGTCCGGAAAGTAAAAAGTGTGGTGCAATTACCTGCAACGGTGTTAATTGTAGGGATT
GCGTATAAAAAAGATGTAAATGATTTGAGAGAATCACCAGCGTTACCGATTATTCAATTATTAAGAAATCAAGGATACGA
GATAGAATATCATGATCCTTATATTTCTTCCGCGGAAATTGGAGATAAGGTGTACCAATCTGTTTCTTTAGATGAAGAAA
AAGTTAAAAAAGCGGATTGTATTTTAATTTTAACGGATCATTCTAATATTGATTGGAAGCTTTTTAAAGGAATAGACCGA
GTAATAGATACACGCGGGATTGTAAAGAAGGTGAGTAAATGA

Upstream 100 bases:

>100_bases
GCGTATTTATTACAATGTACGGACGAACGTGGTGGTTTTACAGATGGAGATAGAGATAGAGATGTAATTCAACAATTGAG
AAGGGAAGAAGAGAATACAA

Downstream 100 bases:

>100_bases
GTAAGAAATGTTTAATTACAGGTGGAGCCGGATTTATCGGGTCACATTTAGCTGAAGAGTTGATGAGAAGAGGTTATGAG
GTCACTGTTGTGGATAACTT

Product: putative polysaccharide biosynthesis protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIDSIIKGESYIPDVSSKELQSLLTKKKLTVNTPDQGIADFQN
SDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVILPIISQNGKKVGEDFYIGYSPERID
PANSQYSVQAIPKVISGQTEKCRQKVQDLYSTIFDEVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
AIEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHIINEEMPEKMVRKVKSVVQLPATVLIVGI
AYKKDVNDLRESPALPIIQLLRNQGYEIEYHDPYISSAEIGDKVYQSVSLDEEKVKKADCILILTDHSNIDWKLFKGIDR
VIDTRGIVKKVSK

Sequences:

>Translated_413_residues
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIDSIIKGESYIPDVSSKELQSLLTKKKLTVNTPDQGIADFQN
SDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVILPIISQNGKKVGEDFYIGYSPERID
PANSQYSVQAIPKVISGQTEKCRQKVQDLYSTIFDEVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
AIEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHIINEEMPEKMVRKVKSVVQLPATVLIVGI
AYKKDVNDLRESPALPIIQLLRNQGYEIEYHDPYISSAEIGDKVYQSVSLDEEKVKKADCILILTDHSNIDWKLFKGIDR
VIDTRGIVKKVSK
>Mature_413_residues
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIDSIIKGESYIPDVSSKELQSLLTKKKLTVNTPDQGIADFQN
SDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVILPIISQNGKKVGEDFYIGYSPERID
PANSQYSVQAIPKVISGQTEKCRQKVQDLYSTIFDEVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
AIEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHIINEEMPEKMVRKVKSVVQLPATVLIVGI
AYKKDVNDLRESPALPIIQLLRNQGYEIEYHDPYISSAEIGDKVYQSVSLDEEKVKKADCILILTDHSNIDWKLFKGIDR
VIDTRGIVKKVSK

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=431, Percent_Identity=23.6658932714617, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994968, Length=435, Percent_Identity=31.7241379310345, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788340, Length=358, Percent_Identity=22.0670391061453, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136908, Length=404, Percent_Identity=25.990099009901, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46083; Mature: 46083

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIDSIIKGESYIPDVSSKELQSL
CCCCCEEEEEECHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LTKKKLTVNTPDQGIADFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTF
HHHCCCEECCCCCCHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
IFESSTYPGTLEEVILPIISQNGKKVGEDFYIGYSPERIDPANSQYSVQAIPKVISGQTE
EEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHH
KCRQKVQDLYSTIFDEVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AIEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHIINEEMPEK
HHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
MVRKVKSVVQLPATVLIVGIAYKKDVNDLRESPALPIIQLLRNQGYEIEYHDPYISSAEI
HHHHHHHHHHCCHHHHEEEHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCHHH
GDKVYQSVSLDEEKVKKADCILILTDHSNIDWKLFKGIDRVIDTRGIVKKVSK
HHHHHHHCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIDSIIKGESYIPDVSSKELQSL
CCCCCEEEEEECHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LTKKKLTVNTPDQGIADFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTF
HHHCCCEECCCCCCHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
IFESSTYPGTLEEVILPIISQNGKKVGEDFYIGYSPERIDPANSQYSVQAIPKVISGQTE
EEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHH
KCRQKVQDLYSTIFDEVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
AIEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHIINEEMPEK
HHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
MVRKVKSVVQLPATVLIVGIAYKKDVNDLRESPALPIIQLLRNQGYEIEYHDPYISSAEI
HHHHHHHHHHCCHHHHEEEHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCHHH
GDKVYQSVSLDEEKVKKADCILILTDHSNIDWKLFKGIDRVIDTRGIVKKVSK
HHHHHHHCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]