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The map label for this gene is arnA [H]

Identifier: 218232522

GI number: 218232522

Start: 494567

End: 495532

Strand: Direct

Name: arnA [H]

Synonym: BCB4264_A0510

Alternate gene names: 218232522

Gene position: 494567-495532 (Clockwise)

Preceding gene: 218233449

Following gene: 218231693

Centisome position: 9.13

GC content: 36.13

Gene sequence:

>966_bases
ATGAGTAAGAAATGTTTAATTACAGGTGGAGCCGGATTTATCGGGTCACATTTAGCTGAAGAGTTGATGAGAAGAGGTTA
TGAGGTCACTGTTGTGGATAACTTTTATAAAGGTAAAAATAAGTACCATAAAGAGTTAATGAAAGAAATCCGTGTTATTC
CAATAAGTGTTTTAGATAAAAATTCTATTTATGAATTAGTAGATCAGCATGATGTCGTGTTTCATTTAGCAGCAATTTTA
GGTGTGAAAACAACAATGGAAAAAAGTATAGAGCTCATAGAAACGAATTTTGATGGGACGAGAAATATTTTACAAGCAGC
GCTAAAAGGAAAGAAGAAAGTAGTTTTTGCTTCTACTTCAGAAGTATATGGTAAGGCCAAGCCGCCTTTCTCTGAAGAGG
GAGATCGATTGTACGGGGCAACTTCTAAAATTCGTTGGAGTTATGCGGTTTGTAAAACGTTAGAAGAAACATTATGTTTA
GGATACGCATTAGAAGGCTTACCGGTAACGATTGTTCGATATTTTAATATTTATGGTCCAAGAGCGAAAGATGGTCCGTA
TGCAGGAGTAATTCCGCGATTTATCCGTGCGGCACTGCAAGGAGAAGACATTCTCGTATATGGAGATGGAAAGCAGACAC
GTTGTTTTACGTATGTGAGTGATGCGGTAGAAGCAACAATTCGGGCAATGGATGAGAAGGTAAATGGTGAGATTATTAAT
ATAGGTTCTGAGAATGAACAGAGTATAAAAGAAGTAGCAGAAGTAATTAAAAAATTAACGAATTCTTCTTCGAAGATTGT
ACAAGTGCCTTTTGAAGAAGTATATCCTCATGGTTTTGAAGAAATTCCAAATAGAAGACCAGATGTAACAAAATTAAAAG
AGCTTGTTCAATTTCAGGCGAAAGTAACGTGGGAAAACGGATTGAAGGAAACAATTAAGTGGTTTCGTGAACAAAACAAT
GGCTAA

Upstream 100 bases:

>100_bases
GTATTTTAATTTTAACGGATCATTCTAATATTGATTGGAAGCTTTTTAAAGGAATAGACCGAGTAATAGATACACGCGGG
ATTGTAAAGAAGGTGAGTAA

Downstream 100 bases:

>100_bases
GTCATTATCTGTTATTATTCCTGCATGTAATGAGGTCGATACGATTTCAGACGTTATTCAATCGGTAAGACCATTAAATC
CAGTAGAAATCATTGTAGTA

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSKKCLITGGAGFIGSHLAEELMRRGYEVTVVDNFYKGKNKYHKELMKEIRVIPISVLDKNSIYELVDQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTSEVYGKAKPPFSEEGDRLYGATSKIRWSYAVCKTLEETLCL
GYALEGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
IGSENEQSIKEVAEVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLKELVQFQAKVTWENGLKETIKWFREQNN
G

Sequences:

>Translated_321_residues
MSKKCLITGGAGFIGSHLAEELMRRGYEVTVVDNFYKGKNKYHKELMKEIRVIPISVLDKNSIYELVDQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTSEVYGKAKPPFSEEGDRLYGATSKIRWSYAVCKTLEETLCL
GYALEGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
IGSENEQSIKEVAEVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLKELVQFQAKVTWENGLKETIKWFREQNN
G
>Mature_320_residues
SKKCLITGGAGFIGSHLAEELMRRGYEVTVVDNFYKGKNKYHKELMKEIRVIPISVLDKNSIYELVDQHDVVFHLAAILG
VKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTSEVYGKAKPPFSEEGDRLYGATSKIRWSYAVCKTLEETLCLG
YALEGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIINI
GSENEQSIKEVAEVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLKELVQFQAKVTWENGLKETIKWFREQNNG

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=323, Percent_Identity=37.4613003095975, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI7657641, Length=331, Percent_Identity=28.7009063444109, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI56237023, Length=290, Percent_Identity=25.5172413793103, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI56118217, Length=290, Percent_Identity=25.5172413793103, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI189083684, Length=290, Percent_Identity=25.5172413793103, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI193211614, Length=240, Percent_Identity=25.8333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI8393516, Length=240, Percent_Identity=25.8333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788589, Length=334, Percent_Identity=29.6407185628743, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI48994969, Length=349, Percent_Identity=30.0859598853868, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788353, Length=341, Percent_Identity=29.0322580645161, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1788365, Length=344, Percent_Identity=27.3255813953488, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786974, Length=342, Percent_Identity=22.5146198830409, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790049, Length=326, Percent_Identity=23.6196319018405, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=322, Percent_Identity=34.472049689441, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17568069, Length=334, Percent_Identity=30.5389221556886, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71982035, Length=290, Percent_Identity=26.8965517241379, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=292, Percent_Identity=26.7123287671233, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=337, Percent_Identity=25.5192878338279, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=354, Percent_Identity=23.4463276836158, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=38.8198757763975, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19923002, Length=260, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 36188; Mature: 36057

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKCLITGGAGFIGSHLAEELMRRGYEVTVVDNFYKGKNKYHKELMKEIRVIPISVLDK
CCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHHHCCEEEEECC
NSIYELVDQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECH
EVYGKAKPPFSEEGDRLYGATSKIRWSYAVCKTLEETLCLGYALEGLPVTIVRYFNIYGP
HHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
RAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
IGSENEQSIKEVAEVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLKELVQFQA
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHCCCCCCCHHHHHHHHHHHH
KVTWENGLKETIKWFREQNNG
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKKCLITGGAGFIGSHLAEELMRRGYEVTVVDNFYKGKNKYHKELMKEIRVIPISVLDK
CCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHHHCCEEEEECC
NSIYELVDQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVVFASTS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECH
EVYGKAKPPFSEEGDRLYGATSKIRWSYAVCKTLEETLCLGYALEGLPVTIVRYFNIYGP
HHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
RAKDGPYAGVIPRFIRAALQGEDILVYGDGKQTRCFTYVSDAVEATIRAMDEKVNGEIIN
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
IGSENEQSIKEVAEVIKKLTNSSSKIVQVPFEEVYPHGFEEIPNRRPDVTKLKELVQFQA
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHCCCCCCCHHHHHHHHHHHH
KVTWENGLKETIKWFREQNNG
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA