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The map label for this gene is vanR [H]

Identifier: 218232740

GI number: 218232740

Start: 262850

End: 263551

Strand: Direct

Name: vanR [H]

Synonym: BCB4264_A0303

Alternate gene names: 218232740

Gene position: 262850-263551 (Clockwise)

Preceding gene: 218233002

Following gene: 218232219

Centisome position: 4.85

GC content: 35.47

Gene sequence:

>702_bases
GTGGCACACGAAACAATACTTGTCGTAGATGATGAAAAAGAAATTCGGAATTTAATTACAATCTATTTAAAGAATGAAGG
ATATAAAGTATTACAAGCAGGAGACGGAGAAGAAGGATTACGTCTACTGGAAGAAAATGAAGTACATCTAGTCGTATTAG
ATATTATGATGCCGAAAGTGGATGGTATTCATATGTGTATGAAAGTAAGGGAAGCGAAAGAAATGCCTATTATTATGCTT
TCTGCCAAAACGCAAGATATGGATAAGATTTTAGGATTAACAACAGGAGCAGATGATTATGTAACGAAGCCGTTTAATCC
GTTAGAGTTAATTGCACGAATTAAATCTCAGTTACGCCGTTATATGAAAATGAATGGTTTCGCTATTCAAAATGAGGACG
AGTTAGAAATTGGGGAGATGAAAATCAACATCTCGACCCATAAAGTTATTGTAGAGGGAGAAGAAGTGAAACTAACTCCG
AGGGAATTTTCAATTTTAGAACTGCTAGCTAGAAATCCAGGTATGGTGTTTAGTGCGGAGCAAATTTATGAAAAGGTGTG
GAACGAACGATCTTTCCAGTCTGATAATACTGTAATGGTGCATATTCGAAAAGTACGTGAAAAGATTGAGGAGAATCCAA
GGAAACCTAGATATATAAAAACAGTATGGGGAGTGGGGTATAAGATTGAAAAAGATATTTAA

Upstream 100 bases:

>100_bases
TTTTGCGTCTTCAGAAAATCTTAAGGATTTCCGAGCGTTTTTCTTCAGAAGTTTTCCTATAATAGAAGTTAGGGATTAAA
AAAGTGATGGGGGAGATATT

Downstream 100 bases:

>100_bases
TCCGTTTACTTATATAAGGAAAATAAGAGAATTATTTGAGAAATTAGTAAAGAGCGTACGAAAGAGTATAAGGATTCAAT
TGATTACTACTTTTGCTGCT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MAHETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKVDGIHMCMKVREAKEMPIIML
SAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGFAIQNEDELEIGEMKINISTHKVIVEGEEVKLTP
REFSILELLARNPGMVFSAEQIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI

Sequences:

>Translated_233_residues
MAHETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKVDGIHMCMKVREAKEMPIIML
SAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGFAIQNEDELEIGEMKINISTHKVIVEGEEVKLTP
REFSILELLARNPGMVFSAEQIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI
>Mature_232_residues
AHETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKVDGIHMCMKVREAKEMPIIMLS
AKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGFAIQNEDELEIGEMKINISTHKVIVEGEEVKLTPR
EFSILELLARNPGMVFSAEQIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=39.3013100436681, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=35.0877192982456, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=34.8017621145374, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=34.6666666666667, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=33.6283185840708, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=33.7662337662338, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=36.1233480176211, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=36.7256637168142, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=35.5555555555556, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=30.9012875536481, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=32.4444444444444, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=236, Percent_Identity=32.2033898305085, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=30.3964757709251, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.9475982532751, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.0188679245283, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788905, Length=109, Percent_Identity=33.0275229357798, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27034; Mature: 26903

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKV
CCCCEEEEEECHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCC
DGIHMCMKVREAKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YMKMNGFAIQNEDELEIGEMKINISTHKVIVEGEEVKLTPREFSILELLARNPGMVFSAE
HHHHCCEEECCCCCCEEEEEEEEEEEEEEEEECCEEEECCCHHHHHHHHHCCCCCEEEHH
QIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCEEEHHHCCCEEEECCC
>Mature Secondary Structure 
AHETILVVDDEKEIRNLITIYLKNEGYKVLQAGDGEEGLRLLEENEVHLVVLDIMMPKV
CCCEEEEEECHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCC
DGIHMCMKVREAKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YMKMNGFAIQNEDELEIGEMKINISTHKVIVEGEEVKLTPREFSILELLARNPGMVFSAE
HHHHCCEEECCCCCCEEEEEEEEEEEEEEEEECCEEEECCCHHHHHHHHHCCCCCEEEHH
QIYEKVWNERSFQSDNTVMVHIRKVREKIEENPRKPRYIKTVWGVGYKIEKDI
HHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCEEEHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]