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The map label for this gene is nhaK [H]

Identifier: 213693308

GI number: 213693308

Start: 2780538

End: 2782607

Strand: Direct

Name: nhaK [H]

Synonym: Blon_2462

Alternate gene names: 213693308

Gene position: 2780538-2782607 (Clockwise)

Preceding gene: 213693305

Following gene: 213693311

Centisome position: 98.16

GC content: 59.32

Gene sequence:

>2070_bases
ATGGCGGTATTTGAGCTCATCCTATGCATCATTGCGGCGGTGGTGGTGAGCTCGTTTGCCAGTCGCTTCGTGCCCAAAGT
CTCCACGCCGCTGGTCCAGATTGTGCTGGGCGTGCTGGTTACGTATCTGCCGTTTTTCCCGGATGCAAAGCTCGACCCGG
AACTGTTCATGGTGCTGTTTATCGCGCCATTGCTGTATTTGGAAGCCCACGAAATCGATAAGTCGGCGTTGCTGAAAACG
CTGGATCTGAGCCTATCGCTGGCTATCGGACTGGCTATCGTCACGATGGCGGCGGTCGGATTCACTTTGCATGCCGTCTG
GCCGTCCATCACCTTAGCCTCAGCCTTAGCACTCGGCGCGGCACTCGGCCCGACCGATGCGGTGGCCGTCAGCTCCCTCG
GTAAAGAAGCCTCGCTGACGCAGCGTCAGCGCAGCGTGCTCAAAGGCGAGTCGTTGTTCAACGACGCCTCCGGCATTGTC
GGCTTCCAGTTCGCACTGGCCGCCGCCTTCACCGGAGAATTCGCCGTGGGGCAGGCCGCCGGCGAATTCCTGATGTCCTT
CTTCGGCGGCACCCTGTTCGGCCTGGTCATAGCGGCGGCCAACTGGCTGTTCGAAACCGTGCGGTCCCTGGGCTGGGAGA
CCACCACCACACGCATTCTGATGGAGCTGTTCCTGCCCTTCCTGCTGTATCTGGGCGCGGAGGAATTCAATGTGTCCGGC
ATTCTGTCGGTGGTGGCCGCTGGCCTGTTCATCCGATTCGACCGTACCGGCGTGGGGCCGAATGTGGCACGTACGAATAT
CGTTTCCACTTCAGTATGGGGTGTGCTGAGTTTCTCGCTCAACGGTGCGGTGTTCATTCTTCTGGGCATGCAGCTGCCAC
GCGCCATGAAAGCCAGCTGGTCCGACCCGTATATCAGCAACCTGAAACTCATCGGCATCATCCTGCTGGTGACGCTTGTG
GTGATCGCACTGCGGTTCTTCTGGATAGTGGCCATGCTGCGCGTGGCGCGCGACGTGCATACACGGCGACGGCGCAAGAT
GACCCCCGAACGTTGGCGGTCCGCGACGGTCATGACCTTCGGCGGACCCAAAGGCACCATCACCCTGTCGCTGATGTTCA
CCATCCCGTATTATCTCGCCGGGGGCGCGCCGTTCCCCATGCGCAACGAGTTGATCTTCATCGCATCGGGCGTCATCGTC
GTGACGCTGATGCTGGCCAATTTCCTGCTGCCTTTGCTTGCACCGAACCGTGGCAAGGATCCCAGCGCCGAGATGATTCC
GGTGACCATCGATGTGTTACGCGCCACGGTGGAGGAACTGACCGGACGCATCACGCCAGAGAATCGCCGTGCGATTCTGA
TGGTAATCGACCAGTACACCAAGCGCATCGGGCGATTGCAGCAGCGCATCGGCGATACCGATCCTCAGGGATTCGAGCAA
TTGCAGATCGAAGCGCTGCATTGGGAAAAGGAATTCGTGCGCGACCGGCTTGCCGACACCAAGGCGCATCCAGCGGCGGA
TACGGCCACGCAAGAGCTGAACGTCGAAGCCTGCGAGCGCATGCTTGACCAGATTATGAATACGCTGCGTCACACTTCCA
CTGATCCTACTTCGGGGCATGCGGTATCGCAGATTCGCGGTCGCTTACGCATGTTCCAGCGGCAGATGAGCAACTACGCC
AAACGCACGGTGTCCAAGATTCGCCATACCACGCCGTTGGTGAGCGAGGATCGGATTTTCGCGCGCACCCGCGAACTGCA
GGTCGAGGCGATTCATCATGTTATCGGCCAGCTTATTGACGAGATGGGCCAGGATACGTACAACACCGAGCATTGTTCGG
CGCTGTTGCTGGATTATCGTCGCGCTGCGGCTTCATTGCAGGCACGTCCGAATATGAGCGGCACTACGGAAACCATCACG
CAGGTCGAGGACGTAAAGCGCGAGAGCTACGGCATCGAACTCGGTGTGATTCAGGACATGTACGAAGCCGGCGACATCAA
CCGAACCCAAGCCCGCTCCCTGAGGCGCAACATCTACGTTATGCAGGTCGATGCTGATTCCGGCATCTAG

Upstream 100 bases:

>100_bases
CATATCGTCTCATGATGTGCATAATCGGCCGCAATCTTAACGTTTTTCTTCATGGTTCCCATATACTTTTGGTGGAGAAG
AGATACGAGAAGGCGGCAAC

Downstream 100 bases:

>100_bases
TTTCCTTGGCTCCCTTCTCTGAGGGGAGCCAAGTTGGGGATTGCTATTTCCGTTTCCAGTGATGGCGGCTGACTACAGCA
CGCCAGAAGTAATGTCGTTG

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MAVFELILCIIAAVVVSSFASRFVPKVSTPLVQIVLGVLVTYLPFFPDAKLDPELFMVLFIAPLLYLEAHEIDKSALLKT
LDLSLSLAIGLAIVTMAAVGFTLHAVWPSITLASALALGAALGPTDAVAVSSLGKEASLTQRQRSVLKGESLFNDASGIV
GFQFALAAAFTGEFAVGQAAGEFLMSFFGGTLFGLVIAAANWLFETVRSLGWETTTTRILMELFLPFLLYLGAEEFNVSG
ILSVVAAGLFIRFDRTGVGPNVARTNIVSTSVWGVLSFSLNGAVFILLGMQLPRAMKASWSDPYISNLKLIGIILLVTLV
VIALRFFWIVAMLRVARDVHTRRRRKMTPERWRSATVMTFGGPKGTITLSLMFTIPYYLAGGAPFPMRNELIFIASGVIV
VTLMLANFLLPLLAPNRGKDPSAEMIPVTIDVLRATVEELTGRITPENRRAILMVIDQYTKRIGRLQQRIGDTDPQGFEQ
LQIEALHWEKEFVRDRLADTKAHPAADTATQELNVEACERMLDQIMNTLRHTSTDPTSGHAVSQIRGRLRMFQRQMSNYA
KRTVSKIRHTTPLVSEDRIFARTRELQVEAIHHVIGQLIDEMGQDTYNTEHCSALLLDYRRAAASLQARPNMSGTTETIT
QVEDVKRESYGIELGVIQDMYEAGDINRTQARSLRRNIYVMQVDADSGI

Sequences:

>Translated_689_residues
MAVFELILCIIAAVVVSSFASRFVPKVSTPLVQIVLGVLVTYLPFFPDAKLDPELFMVLFIAPLLYLEAHEIDKSALLKT
LDLSLSLAIGLAIVTMAAVGFTLHAVWPSITLASALALGAALGPTDAVAVSSLGKEASLTQRQRSVLKGESLFNDASGIV
GFQFALAAAFTGEFAVGQAAGEFLMSFFGGTLFGLVIAAANWLFETVRSLGWETTTTRILMELFLPFLLYLGAEEFNVSG
ILSVVAAGLFIRFDRTGVGPNVARTNIVSTSVWGVLSFSLNGAVFILLGMQLPRAMKASWSDPYISNLKLIGIILLVTLV
VIALRFFWIVAMLRVARDVHTRRRRKMTPERWRSATVMTFGGPKGTITLSLMFTIPYYLAGGAPFPMRNELIFIASGVIV
VTLMLANFLLPLLAPNRGKDPSAEMIPVTIDVLRATVEELTGRITPENRRAILMVIDQYTKRIGRLQQRIGDTDPQGFEQ
LQIEALHWEKEFVRDRLADTKAHPAADTATQELNVEACERMLDQIMNTLRHTSTDPTSGHAVSQIRGRLRMFQRQMSNYA
KRTVSKIRHTTPLVSEDRIFARTRELQVEAIHHVIGQLIDEMGQDTYNTEHCSALLLDYRRAAASLQARPNMSGTTETIT
QVEDVKRESYGIELGVIQDMYEAGDINRTQARSLRRNIYVMQVDADSGI
>Mature_688_residues
AVFELILCIIAAVVVSSFASRFVPKVSTPLVQIVLGVLVTYLPFFPDAKLDPELFMVLFIAPLLYLEAHEIDKSALLKTL
DLSLSLAIGLAIVTMAAVGFTLHAVWPSITLASALALGAALGPTDAVAVSSLGKEASLTQRQRSVLKGESLFNDASGIVG
FQFALAAAFTGEFAVGQAAGEFLMSFFGGTLFGLVIAAANWLFETVRSLGWETTTTRILMELFLPFLLYLGAEEFNVSGI
LSVVAAGLFIRFDRTGVGPNVARTNIVSTSVWGVLSFSLNGAVFILLGMQLPRAMKASWSDPYISNLKLIGIILLVTLVV
IALRFFWIVAMLRVARDVHTRRRRKMTPERWRSATVMTFGGPKGTITLSLMFTIPYYLAGGAPFPMRNELIFIASGVIVV
TLMLANFLLPLLAPNRGKDPSAEMIPVTIDVLRATVEELTGRITPENRRAILMVIDQYTKRIGRLQQRIGDTDPQGFEQL
QIEALHWEKEFVRDRLADTKAHPAADTATQELNVEACERMLDQIMNTLRHTSTDPTSGHAVSQIRGRLRMFQRQMSNYAK
RTVSKIRHTTPLVSEDRIFARTRELQVEAIHHVIGQLIDEMGQDTYNTEHCSALLLDYRRAAASLQARPNMSGTTETITQ
VEDVKRESYGIELGVIQDMYEAGDINRTQARSLRRNIYVMQVDADSGI

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790501, Length=547, Percent_Identity=32.1755027422303, Blast_Score=222, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI25150332, Length=396, Percent_Identity=23.2323232323232, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980847, Length=367, Percent_Identity=23.9782016348774, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 76035; Mature: 75904

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCHHHHHHHHCCEEEEEECCCCCC
>Mature Secondary Structure 
AVFELILCIIAAVVVSSFASRFVPKVSTPLVQIVLGVLVTYLPFFPDAKLDPELFMVLF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
IAPLLYLEAHEIDKSALLKTLDLSLSLAIGLAIVTMAAVGFTLHAVWPSITLASALALGA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGPTDAVAVSSLGKEASLTQRQRSVLKGESLFNDASGIVGFQFALAAAFTGEFAVGQAA
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
GEFLMSFFGGTLFGLVIAAANWLFETVRSLGWETTTTRILMELFLPFLLYLGAEEFNVSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ILSVVAAGLFIRFDRTGVGPNVARTNIVSTSVWGVLSFSLNGAVFILLGMQLPRAMKASW
HHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECHHCCHHHHCCC
SDPYISNLKLIGIILLVTLVVIALRFFWIVAMLRVARDVHTRRRRKMTPERWRSATVMTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEE
GGPKGTITLSLMFTIPYYLAGGAPFPMRNELIFIASGVIVVTLMLANFLLPLLAPNRGKD
CCCCCEEEEEEHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
PSAEMIPVTIDVLRATVEELTGRITPENRRAILMVIDQYTKRIGRLQQRIGDTDPQGFEQ
CCCCEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHH
LQIEALHWEKEFVRDRLADTKAHPAADTATQELNVEACERMLDQIMNTLRHTSTDPTSGH
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCH
AVSQIRGRLRMFQRQMSNYAKRTVSKIRHTTPLVSEDRIFARTRELQVEAIHHVIGQLID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EMGQDTYNTEHCSALLLDYRRAAASLQARPNMSGTTETITQVEDVKRESYGIELGVIQDM
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
YEAGDINRTQARSLRRNIYVMQVDADSGI
HHCCCCCHHHHHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA