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The map label for this gene is ilvD

Identifier: 213692987

GI number: 213692987

Start: 2358854

End: 2360716

Strand: Reverse

Name: ilvD

Synonym: Blon_2134

Alternate gene names: 213692987

Gene position: 2360716-2358854 (Counterclockwise)

Preceding gene: 213692993

Following gene: 213692982

Centisome position: 83.34

GC content: 64.2

Gene sequence:

>1863_bases
ATGACTGAAATGCGATCTGCAAAAATTATGTCAGGGCGCGTCTTTGCAGGCGCCCGAGCCCTCTACCGTGCTGCGGGCGT
CAGCGGAGACGACATGGGCAAGAAGCCCATCATCGCCATCGCCAACTCGTTCGATGAGTTCCTGCCCGGCCACGTCCACC
TCAACAAGGTCGGCCGCATCGTTTCCGAGGCTATCAAGGAAGCCGGCGGCATTCCGCGCGAGTTCAACACGATGGCCGTG
GACGACGGCATCGCCATGGGCCACACTGGCATGCTCTACTCCCTGCCTTCCCGCGACATCATCGCCGACACCGTCGAATA
CCAGTGCAACGCGCACTGCGCCGACGCCCTGATCTGCATCCCGAACTGCGACAAGGTCGTGCCGGGCATGCTGATGGCAG
CCCTGCGCCTCAACATTCCGACCGTGTTCGTCTCCGGTGGCCCGATGGAGGCCGGCACCACGGTGCTCGCCGACGGCACA
GTCAAGAGCACCGACCTTATCGACGTGATGTACGCCACCGCCGACGACAGCGTCTCCGATGAGGAACTGCTCAACTATGA
GAAGACCGTCTGCCCGACCTGCGGCTCCTGCGCCGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAGGCCATCG
GCCTGGCCCTGCCCGGCAACGGCACCATCCTCGCCTCCCACTCCTACCGCAAGGACCTGTTCGAGCGTGCCGCCAAGCAG
GTCGTCAAGATCGCGCACCAGTACTACGACGATTCCGACGATTCCGTGCTGCCACGCTCCATCGCCACCAAGGAAGCCTT
CGAGAACGCCATGACCATGGATGTGGCCATGGGCGGTTCCACCAACACCGTGCTGCACATCCTCGCCATGGCCCAGTCCG
CCGACGTGGACTTCACCCTGGACGACATCGAGCGCATTTCCCACACCGTGCCGTGCATCTGCAAGGCCTCGCCGTCCGGC
AAGTGGGAGATTTCCGACGTGCACCGCGCCGGCGGCATCACCGGCATCCTCGGCGAGCTCGACCGCGCCGGCAAGCTGCA
CACCAACGTGCACTCCATCGACTACCCGACGCTGGAAGCCAAGCTGGCCGATTGGGACATCATGCGCCCGACCTGCACCG
AGGAAGCCCAGCAGATGTACAAGGCCGCTCCTGGCCACATCATCTCCCCGGAGCCGTGGACGCACACCACCCTGTTCGAC
TCGCTCGACCGCGACCGTACCAACGGCGCCATCCACGACATCGATCATCCCGAAATCCATGAAGGCGGCCTCGCCGTGCT
GCGCGGCAACCTGGCCCCCGACGGCTGCGTGGTCAAGACCGCCGGTGTTCCGCCGGAGATCTGGAAGTTCCGTGGACCGG
CTCTGGTGGTCGACTCCCAGGAGCAGGCCATCGAGGTCATTCTGAACGATACCCTGAAGCCCGGCATGGCGCTTGTGATT
CGTTACGAAGGCCCGAAGGGTGGCCCGGGCATGCAGGAAATGCTGTACCCGACCTCCTTCGTCAAGGGCAAGGGCATCGG
CAAGCAGGTCGCCATGCTCACCGACGGTCGCTACTCCGGCGGTTCCTCCGGTCTGGCCATCGGCCACATGGCGCCTGAGG
CTGCCAATAAGGGCCCGGTGGCGCTCATCAGGAACGGCGACATCATCGATATCGATATCGAAGCCCGTTCCGTGAACGTC
GAACTGACTGACGAGCAGTTGGACGAGCGTCGCCGTGAACTCGAGGCCGGCGACGGCTACGTGGCTCACCGCAACCGCCA
CGTCTCCCAAGCGCTGAAGGCGTACGCCGCCTTCGCCCGCTCGGCCGACAAGGGTGCGACGCGTGACCCGGAGCTGATCA
ACAAGCTCTCCGGTCTCGACTGA

Upstream 100 bases:

>100_bases
GTATTCCAAAAAATATGTGTAAGAAACGTTACGTTTTTGCCAATTCCATTATTCGACTCTTGACAAGCGGCGTGTCCCTC
GCAAAGGCTTGAATAGAGCC

Downstream 100 bases:

>100_bases
TCGCCGATTGTATAGCTGAAAAGCCCGGTATCTTCCTCGCGAAGATGCCGGGCTTTTTGCTGTGCTTCCGATGACGGGAG
CGATATTGCTTGTTATCGCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MTEMRSAKIMSGRVFAGARALYRAAGVSGDDMGKKPIIAIANSFDEFLPGHVHLNKVGRIVSEAIKEAGGIPREFNTMAV
DDGIAMGHTGMLYSLPSRDIIADTVEYQCNAHCADALICIPNCDKVVPGMLMAALRLNIPTVFVSGGPMEAGTTVLADGT
VKSTDLIDVMYATADDSVSDEELLNYEKTVCPTCGSCAGMFTANSMNCLTEAIGLALPGNGTILASHSYRKDLFERAAKQ
VVKIAHQYYDDSDDSVLPRSIATKEAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSG
KWEISDVHRAGGITGILGELDRAGKLHTNVHSIDYPTLEAKLADWDIMRPTCTEEAQQMYKAAPGHIISPEPWTHTTLFD
SLDRDRTNGAIHDIDHPEIHEGGLAVLRGNLAPDGCVVKTAGVPPEIWKFRGPALVVDSQEQAIEVILNDTLKPGMALVI
RYEGPKGGPGMQEMLYPTSFVKGKGIGKQVAMLTDGRYSGGSSGLAIGHMAPEAANKGPVALIRNGDIIDIDIEARSVNV
ELTDEQLDERRRELEAGDGYVAHRNRHVSQALKAYAAFARSADKGATRDPELINKLSGLD

Sequences:

>Translated_620_residues
MTEMRSAKIMSGRVFAGARALYRAAGVSGDDMGKKPIIAIANSFDEFLPGHVHLNKVGRIVSEAIKEAGGIPREFNTMAV
DDGIAMGHTGMLYSLPSRDIIADTVEYQCNAHCADALICIPNCDKVVPGMLMAALRLNIPTVFVSGGPMEAGTTVLADGT
VKSTDLIDVMYATADDSVSDEELLNYEKTVCPTCGSCAGMFTANSMNCLTEAIGLALPGNGTILASHSYRKDLFERAAKQ
VVKIAHQYYDDSDDSVLPRSIATKEAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSG
KWEISDVHRAGGITGILGELDRAGKLHTNVHSIDYPTLEAKLADWDIMRPTCTEEAQQMYKAAPGHIISPEPWTHTTLFD
SLDRDRTNGAIHDIDHPEIHEGGLAVLRGNLAPDGCVVKTAGVPPEIWKFRGPALVVDSQEQAIEVILNDTLKPGMALVI
RYEGPKGGPGMQEMLYPTSFVKGKGIGKQVAMLTDGRYSGGSSGLAIGHMAPEAANKGPVALIRNGDIIDIDIEARSVNV
ELTDEQLDERRRELEAGDGYVAHRNRHVSQALKAYAAFARSADKGATRDPELINKLSGLD
>Mature_619_residues
TEMRSAKIMSGRVFAGARALYRAAGVSGDDMGKKPIIAIANSFDEFLPGHVHLNKVGRIVSEAIKEAGGIPREFNTMAVD
DGIAMGHTGMLYSLPSRDIIADTVEYQCNAHCADALICIPNCDKVVPGMLMAALRLNIPTVFVSGGPMEAGTTVLADGTV
KSTDLIDVMYATADDSVSDEELLNYEKTVCPTCGSCAGMFTANSMNCLTEAIGLALPGNGTILASHSYRKDLFERAAKQV
VKIAHQYYDDSDDSVLPRSIATKEAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGK
WEISDVHRAGGITGILGELDRAGKLHTNVHSIDYPTLEAKLADWDIMRPTCTEEAQQMYKAAPGHIISPEPWTHTTLFDS
LDRDRTNGAIHDIDHPEIHEGGLAVLRGNLAPDGCVVKTAGVPPEIWKFRGPALVVDSQEQAIEVILNDTLKPGMALVIR
YEGPKGGPGMQEMLYPTSFVKGKGIGKQVAMLTDGRYSGGSSGLAIGHMAPEAANKGPVALIRNGDIIDIDIEARSVNVE
LTDEQLDERRRELEAGDGYVAHRNRHVSQALKAYAAFARSADKGATRDPELINKLSGLD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=622, Percent_Identity=56.5916398713826, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=584, Percent_Identity=27.3972602739726, Blast_Score=202, Evalue=7e-53,
Organism=Escherichia coli, GI2367371, Length=539, Percent_Identity=30.6122448979592, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786464, Length=526, Percent_Identity=27.9467680608365, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=598, Percent_Identity=35.2842809364548, Blast_Score=329, Evalue=8e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BIFLI (B7GUP9)

Other databases:

- EMBL:   CP001095
- RefSeq:   YP_002323573.1
- GeneID:   7054190
- GenomeReviews:   CP001095_GR
- KEGG:   bln:Blon_2134
- HOGENOM:   HBG671001
- ProtClustDB:   PRK12448
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 66533; Mature: 66402

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMRSAKIMSGRVFAGARALYRAAGVSGDDMGKKPIIAIANSFDEFLPGHVHLNKVGRI
CCCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHCCCCEEHHHHHHH
VSEAIKEAGGIPREFNTMAVDDGIAMGHTGMLYSLPSRDIIADTVEYQCNAHCADALICI
HHHHHHHHCCCCCCCCCEEECCCCEECCCCEEEECCCCCHHHHHHHHCCCCCCCCEEEEC
PNCDKVVPGMLMAALRLNIPTVFVSGGPMEAGTTVLADGTVKSTDLIDVMYATADDSVSD
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCH
EELLNYEKTVCPTCGSCAGMFTANSMNCLTEAIGLALPGNGTILASHSYRKDLFERAAKQ
HHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCEEECCCCCEEECCHHHHHHHHHHHHH
VVKIAHQYYDDSDDSVLPRSIATKEAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHCCCCCEEH
DDIERISHTVPCICKASPSGKWEISDVHRAGGITGILGELDRAGKLHTNVHSIDYPTLEA
HHHHHHHCCCCEEEECCCCCCEEEHHHHHHCCHHHHHHHHHCCCCEECCEECCCCCCCEE
KLADWDIMRPTCTEEAQQMYKAAPGHIISPEPWTHTTLFDSLDRDRTNGAIHDIDHPEIH
EECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCC
EGGLAVLRGNLAPDGCVVKTAGVPPEIWKFRGPALVVDSQEQAIEVILNDTLKPGMALVI
CCCEEEEECCCCCCCEEEEECCCCHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCEEEEE
RYEGPKGGPGMQEMLYPTSFVKGKGIGKQVAMLTDGRYSGGSSGLAIGHMAPEAANKGPV
EECCCCCCCCHHHHHCCHHHHCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCE
ALIRNGDIIDIDIEARSVNVELTDEQLDERRRELEAGDGYVAHRNRHVSQALKAYAAFAR
EEEECCCEEEEEEEEEEEEEEECHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
SADKGATRDPELINKLSGLD
CCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TEMRSAKIMSGRVFAGARALYRAAGVSGDDMGKKPIIAIANSFDEFLPGHVHLNKVGRI
CCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHCCCCEEHHHHHHH
VSEAIKEAGGIPREFNTMAVDDGIAMGHTGMLYSLPSRDIIADTVEYQCNAHCADALICI
HHHHHHHHCCCCCCCCCEEECCCCEECCCCEEEECCCCCHHHHHHHHCCCCCCCCEEEEC
PNCDKVVPGMLMAALRLNIPTVFVSGGPMEAGTTVLADGTVKSTDLIDVMYATADDSVSD
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCH
EELLNYEKTVCPTCGSCAGMFTANSMNCLTEAIGLALPGNGTILASHSYRKDLFERAAKQ
HHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCEEECCCCCEEECCHHHHHHHHHHHHH
VVKIAHQYYDDSDDSVLPRSIATKEAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHCCCCCEEH
DDIERISHTVPCICKASPSGKWEISDVHRAGGITGILGELDRAGKLHTNVHSIDYPTLEA
HHHHHHHCCCCEEEECCCCCCEEEHHHHHHCCHHHHHHHHHCCCCEECCEECCCCCCCEE
KLADWDIMRPTCTEEAQQMYKAAPGHIISPEPWTHTTLFDSLDRDRTNGAIHDIDHPEIH
EECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCC
EGGLAVLRGNLAPDGCVVKTAGVPPEIWKFRGPALVVDSQEQAIEVILNDTLKPGMALVI
CCCEEEEECCCCCCCEEEEECCCCHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCEEEEE
RYEGPKGGPGMQEMLYPTSFVKGKGIGKQVAMLTDGRYSGGSSGLAIGHMAPEAANKGPV
EECCCCCCCCHHHHHCCHHHHCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCE
ALIRNGDIIDIDIEARSVNVELTDEQLDERRRELEAGDGYVAHRNRHVSQALKAYAAFAR
EEEECCCEEEEEEEEEEEEEEECHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
SADKGATRDPELINKLSGLD
CCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA