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The map label for this gene is ptpA [H]

Identifier: 213692993

GI number: 213692993

Start: 2366414

End: 2366932

Strand: Reverse

Name: ptpA [H]

Synonym: Blon_2140

Alternate gene names: 213692993

Gene position: 2366932-2366414 (Counterclockwise)

Preceding gene: 213692994

Following gene: 213692987

Centisome position: 83.56

GC content: 60.89

Gene sequence:

>519_bases
ATGAGCAATACCCAACCCTACACCGTAATGACCGTCTGCACCGGCAATATCTGCCGTTCGCCTATGGGCGAGATCATTCT
GCGTCACTTCTTTAATGAGCGCGGTCTTGGCGACCAGGTGAACGTGGAATCCAGTGGTGTGTCCGACGAGGAGTGGAGCC
ACCCGATCGACCCGCGTGCCGTGCGCGTGCTACGCGAACGTGGCTATGGTGATGAGATTCCGCGTGACCACTTCGCACAC
CGCATCTCACGTGAGGAAATCGACCGTACCGACCTGTTCCTGCCGATGACCGCCTCCCACATGCGCGCCCTACTGCGCAT
GCTGCCGTCCGGCAAGCGCGCCGAAGTGCACATGTACCGCAGCTTCGACCCGAATCTGCCCAAGCCGAAGCCCGGCCGCG
AAGATCAGATCGATCTGGTGGACCCGTGGTACGGCGGCAAGCACGAGTTCGAGGTCGCCATCGACCAGATTGAGGAAGTC
GCCCCGTACATCGTCGATTGGGTGGCGAAGCAGCTGTAG

Upstream 100 bases:

>100_bases
TTTATAGCGGCATGAGCCGGATTCATATTCATTCGACCCCAACAATACAGTCGGGCCGTGTGCGGCCCGTTGAAGTCCGA
TTGAGGATTTATTCAAAGCT

Downstream 100 bases:

>100_bases
GAATCGGCCTGTGGCCGATGCTGTGTGTTTCGCAGTCTTACGACTGCGGGTCACCGCTTTGCGCTGCCACCTCCCTCTGT
AAGGGAGGTGGCAGCGCAAA

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: PTPase; Small, acidic phosphotyrosine protein phosphatase; PY protein phosphatase [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSNTQPYTVMTVCTGNICRSPMGEIILRHFFNERGLGDQVNVESSGVSDEEWSHPIDPRAVRVLRERGYGDEIPRDHFAH
RISREEIDRTDLFLPMTASHMRALLRMLPSGKRAEVHMYRSFDPNLPKPKPGREDQIDLVDPWYGGKHEFEVAIDQIEEV
APYIVDWVAKQL

Sequences:

>Translated_172_residues
MSNTQPYTVMTVCTGNICRSPMGEIILRHFFNERGLGDQVNVESSGVSDEEWSHPIDPRAVRVLRERGYGDEIPRDHFAH
RISREEIDRTDLFLPMTASHMRALLRMLPSGKRAEVHMYRSFDPNLPKPKPGREDQIDLVDPWYGGKHEFEVAIDQIEEV
APYIVDWVAKQL
>Mature_171_residues
SNTQPYTVMTVCTGNICRSPMGEIILRHFFNERGLGDQVNVESSGVSDEEWSHPIDPRAVRVLRERGYGDEIPRDHFAHR
ISREEIDRTDLFLPMTASHMRALLRMLPSGKRAEVHMYRSFDPNLPKPKPGREDQIDLVDPWYGGKHEFEVAIDQIEEVA
PYIVDWVAKQL

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=159, Percent_Identity=31.4465408805031, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI4757714, Length=159, Percent_Identity=29.559748427673, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325330, Length=151, Percent_Identity=28.476821192053, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI78706770, Length=149, Percent_Identity=32.2147651006711, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI78706772, Length=149, Percent_Identity=32.2147651006711, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI78706766, Length=150, Percent_Identity=28.6666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI78706768, Length=150, Percent_Identity=28.6666666666667, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 19859; Mature: 19728

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQPYTVMTVCTGNICRSPMGEIILRHFFNERGLGDQVNVESSGVSDEEWSHPIDPRA
CCCCCCEEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHH
VRVLRERGYGDEIPRDHFAHRISREEIDRTDLFLPMTASHMRALLRMLPSGKRAEVHMYR
HHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHCCCCCCCEEEEEE
SFDPNLPKPKPGREDQIDLVDPWYGGKHEFEVAIDQIEEVAPYIVDWVAKQL
CCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTQPYTVMTVCTGNICRSPMGEIILRHFFNERGLGDQVNVESSGVSDEEWSHPIDPRA
CCCCCEEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHH
VRVLRERGYGDEIPRDHFAHRISREEIDRTDLFLPMTASHMRALLRMLPSGKRAEVHMYR
HHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHCCCCCCCEEEEEE
SFDPNLPKPKPGREDQIDLVDPWYGGKHEFEVAIDQIEEVAPYIVDWVAKQL
CCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550407; 12000953 [H]