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The map label for this gene is lplA [H]

Identifier: 213692925

GI number: 213692925

Start: 2284038

End: 2285123

Strand: Reverse

Name: lplA [H]

Synonym: Blon_2069

Alternate gene names: 213692925

Gene position: 2285123-2284038 (Counterclockwise)

Preceding gene: 213692926

Following gene: 213692924

Centisome position: 80.67

GC content: 57.37

Gene sequence:

>1086_bases
ATGCAAATACGACATGGGGAATGCAAAACCGTTGGCGGCAAACTAGTCGCCGTGACCGTATCCGTCGATGATGACGGCAC
CGCACAGTCATGCCATATCAGTGGTGATTTCTTTATTGAATCAGTTTCGGATGCCGAATCTCATGCTTTGTTACATGACC
TGGAACAAGCGCTAATTAGCGATGATTCATTGCGGTCCGTATTGGACGCTCATCCAAGTTGCCGAATTATCGGCACCGAT
GAAGTTGCCATCAAAACCGCATACAGCCGAGCCGTAAGCAGCAACTTGCCCCCGCTGGCGGGGGCTCCCGCGCAGCGGGT
GGGGGTGGTCAGCCCCGATGCGCCGAACATCCCAGCATCCATCAATACACAAACCAAACAGTCCGACAAAAGCTCTGAAT
ACCGGGAGCGTTGGAACGCCCTCAAGCCTCAACTCACCGTGATCCACGACCATCCGCGTACTCCGGACGAACAAATGGCC
ATTGACGAGACCTGGGCGCGTGAAGTCGCAGCAGGAACACGACAGCCGACCATCCGATTATGGGAGTGGGTGGGCCCGGC
TGTGGTCATCGGCCGTTTCCAATCGGCCCAGGACGAGGTGAATCTGGACATTGCCAAGCAGCTCGGCTTCGACGTGGTAC
GCCGTTGCACGGGTGGCGGAGCGATGTTTATCGAACCGGGCAACACCATTACCTATTCTCTGTATGCACCGCTCGATTTC
GTTCAGGGCGTAAGCATCGAAGAATCCTACCGGCTCTGTGACTGGTGGCTGGTCGAAGCGCTGCGCGAACTTGGTTTGGA
TGTGCGGTTCACGGGCCTCAATGATATCGCCTCGCAGTACGGCAAGATCGGGGGAGCGGCGCAGCGGCGCTTCCCCGTAG
GCTCAGGCGGCGCGGTGCTGCACCATGTGACCATGGCATATGACATCGATGCGGCCAAGATGAGCCGTGTGCTCAACACC
AGTCACGAGAAGATGTCAGACAAAGCGGTGAAATCAGCGGTCAAACGCGTGGACCCGATGAAAAGCCAGACGGGTCTCAG
CCGGGCGCGGATCGTCGAACACCTCATCGACTGGTTCTCCGCATGA

Upstream 100 bases:

>100_bases
GCTCCACCGACCAGGTCGGCAAGGACATTCTGGCCCGCATGTGACCTCAAACTTGGCTCCCCTTCAGAGGGGAGCCAGAA
AACTCTCTATACTGAGTTGC

Downstream 100 bases:

>100_bases
GCGTCCGCGCCGAACGGGCGCGTTACAATATGACAGTCGAGGTCAGGCACGGGACGATCGATAAGGATGGTGCGATGAGC
TTGGAAACGCCAAACGCTTT

Product: biotin/lipoate A/B protein ligase

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MQIRHGECKTVGGKLVAVTVSVDDDGTAQSCHISGDFFIESVSDAESHALLHDLEQALISDDSLRSVLDAHPSCRIIGTD
EVAIKTAYSRAVSSNLPPLAGAPAQRVGVVSPDAPNIPASINTQTKQSDKSSEYRERWNALKPQLTVIHDHPRTPDEQMA
IDETWAREVAAGTRQPTIRLWEWVGPAVVIGRFQSAQDEVNLDIAKQLGFDVVRRCTGGGAMFIEPGNTITYSLYAPLDF
VQGVSIEESYRLCDWWLVEALRELGLDVRFTGLNDIASQYGKIGGAAQRRFPVGSGGAVLHHVTMAYDIDAAKMSRVLNT
SHEKMSDKAVKSAVKRVDPMKSQTGLSRARIVEHLIDWFSA

Sequences:

>Translated_361_residues
MQIRHGECKTVGGKLVAVTVSVDDDGTAQSCHISGDFFIESVSDAESHALLHDLEQALISDDSLRSVLDAHPSCRIIGTD
EVAIKTAYSRAVSSNLPPLAGAPAQRVGVVSPDAPNIPASINTQTKQSDKSSEYRERWNALKPQLTVIHDHPRTPDEQMA
IDETWAREVAAGTRQPTIRLWEWVGPAVVIGRFQSAQDEVNLDIAKQLGFDVVRRCTGGGAMFIEPGNTITYSLYAPLDF
VQGVSIEESYRLCDWWLVEALRELGLDVRFTGLNDIASQYGKIGGAAQRRFPVGSGGAVLHHVTMAYDIDAAKMSRVLNT
SHEKMSDKAVKSAVKRVDPMKSQTGLSRARIVEHLIDWFSA
>Mature_361_residues
MQIRHGECKTVGGKLVAVTVSVDDDGTAQSCHISGDFFIESVSDAESHALLHDLEQALISDDSLRSVLDAHPSCRIIGTD
EVAIKTAYSRAVSSNLPPLAGAPAQRVGVVSPDAPNIPASINTQTKQSDKSSEYRERWNALKPQLTVIHDHPRTPDEQMA
IDETWAREVAAGTRQPTIRLWEWVGPAVVIGRFQSAQDEVNLDIAKQLGFDVVRRCTGGGAMFIEPGNTITYSLYAPLDF
VQGVSIEESYRLCDWWLVEALRELGLDVRFTGLNDIASQYGKIGGAAQRRFPVGSGGAVLHHVTMAYDIDAAKMSRVLNT
SHEKMSDKAVKSAVKRVDPMKSQTGLSRARIVEHLIDWFSA

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 39462; Mature: 39462

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRHGECKTVGGKLVAVTVSVDDDGTAQSCHISGDFFIESVSDAESHALLHDLEQALIS
CCCCCCCCEECCCEEEEEEEEECCCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHC
DDSLRSVLDAHPSCRIIGTDEVAIKTAYSRAVSSNLPPLAGAPAQRVGVVSPDAPNIPAS
CHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCEEECCCCCCCCCC
INTQTKQSDKSSEYRERWNALKPQLTVIHDHPRTPDEQMAIDETWAREVAAGTRQPTIRL
CCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
WEWVGPAVVIGRFQSAQDEVNLDIAKQLGFDVVRRCTGGGAMFIEPGNTITYSLYAPLDF
HHHHCHHHHHHCHHCCCHHCCHHHHHHHCHHHHHHHCCCCEEEEECCCEEEEEEECCHHH
VQGVSIEESYRLCDWWLVEALRELGLDVRFTGLNDIASQYGKIGGAAQRRFPVGSGGAVL
HCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCHHHCCCCCCCCHHH
HHVTMAYDIDAAKMSRVLNTSHEKMSDKAVKSAVKRVDPMKSQTGLSRARIVEHLIDWFS
EEEEHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MQIRHGECKTVGGKLVAVTVSVDDDGTAQSCHISGDFFIESVSDAESHALLHDLEQALIS
CCCCCCCCEECCCEEEEEEEEECCCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHC
DDSLRSVLDAHPSCRIIGTDEVAIKTAYSRAVSSNLPPLAGAPAQRVGVVSPDAPNIPAS
CHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCEEECCCCCCCCCC
INTQTKQSDKSSEYRERWNALKPQLTVIHDHPRTPDEQMAIDETWAREVAAGTRQPTIRL
CCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
WEWVGPAVVIGRFQSAQDEVNLDIAKQLGFDVVRRCTGGGAMFIEPGNTITYSLYAPLDF
HHHHCHHHHHHCHHCCCHHCCHHHHHHHCHHHHHHHCCCCEEEEECCCEEEEEEECCHHH
VQGVSIEESYRLCDWWLVEALRELGLDVRFTGLNDIASQYGKIGGAAQRRFPVGSGGAVL
HCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCHHHCCCCCCCCHHH
HHVTMAYDIDAAKMSRVLNTSHEKMSDKAVKSAVKRVDPMKSQTGLSRARIVEHLIDWFS
EEEEHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]